The Pulmonary Blood Volume in Man*

Dock, Donald S.; Kraus, W. Lee; McGuire, Lockhart B.; Hyland, John W.; Haynes, Florence W.; Dexter, Lewis

doi:10.1172/jci104259

Cited by 125 publications

(56 citation statements)

References 16 publications

(10 reference statements)

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“…Such a relationship has led some authors to ascribe an important role to the pulmonary or central blood volume in determining the stroke volume (12,(30)(31)(32) and cardiac output (25,30), in agreement with previously reported observations (33)(34)(35). These findings either were not confirmed by other workers (16,36) or were not always observed after some circulatory alterations had been induced by various methods and drugs (11,30,32,37,38). The most evident explanation for these apparent discrepancies is that the ventricular filling pressure is the only way through which the pulmonary blood volume can influence the stroke volume and work (39).…”

Section: Resultsmentioning

confidence: 81%

Behavior of Normal Pulmonary Circulation during Changes of Total Blood Volume in Man*

Freitas¹,

Faraco²,

Azevedo³

et al. 1965

J. Clin. Invest.

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Section: Resultsmentioning

confidence: 81%

Behavior of Normal Pulmonary Circulation during Changes of Total Blood Volume in Man*

Freitas¹,

Faraco²,

Azevedo³

et al. 1965

J. Clin. Invest.

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“…Whereas some authors observed a positive relation between PBV and stroke volume (1,5,9,10,14), this relationship cannot be derived from data published by others (4, 6-8) and a negative relationship between these parameters has been published by yet another group (11). Similarly, whereas a positive correlation between left atrial pressure and PBV has been confirmed by some workers (3,5,10), it is specifically denied by others (9). Contradictory results regarding the effects of pulmonary vascular resistance on PBV have also been published (1, [3][4][5]10).…”

Section: Resultsmentioning

confidence: 89%

“…Similarly, whereas a positive correlation between left atrial pressure and PBV has been confirmed by some workers (3,5,10), it is specifically denied by others (9). Contradictory results regarding the effects of pulmonary vascular resistance on PBV have also been published (1, [3][4][5]10).…”

Section: Resultsmentioning

confidence: 94%

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Determinants of pulmonary blood volume

Lewis¹,

Gnoj²,

Fisher³

et al. 1970

J. Clin. Invest.

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A B S T R A C T Pulmonary blood volume was determined by the radiocardiographic technique in 49 patients coming to cardiac catheterization. Since this method has not been directly compared with the more commonly useddouble injection of dye, 25 comparisons were carried out in 13 patients of the series. Agreement was good over a range of 4.5-21.1 heart cycles since there was no statistically significant difference between transit time values measured by the two methods.The relation of pulmonary blood volume to other hemodynamic factors in these 49 patients, with and without cardiac or pulmonary disease, was evaluated by means of multiple regression analysis. The analysis carried out for mean transit time indicates that this parameter varies predominately with flow. Pulmonary blood volume, in this series of resting recumbent individuals, varies to a significant degree only with total blood volume and with pulmonary venous pressure. No parameters of vascular distensibility, such as pulmonary vascular resistance, were found to affect the volume of blood in the lungs.The fact that variations in pulmonary blood volume among the subjects could be described by a multiple regression equation linear with respect to total blood volume and pulmonary venous pressure indicates that these variations are the result of passive distention of components of the vascular bed.

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“…The actual parameters of these frequency functions are given in Table I. They have been selected on the basis of the following data: the dispersion of the left-heart activity curves recorded by precordial counting (e.g., Figure 1), the values of t. observed in man with precordial counting (20), and the values of PMTT obtained in man by combined catheterization of the right and left hearts (1)(2)(3)(4).…”

Section: Extension Of the Principle To Radiocardiographymentioning

confidence: 99%

A Study of the Pulmonary Blood Volume in Man by Quantitative Radiocardiography*

Giuntini¹,

Lewis²,

Luís³

et al. 1963

J. Clin. Invest.

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Determination of the pulmonary blood volume, as distinguished from the central blood volume, has been hampered by the inaccessibility of the outflow of the pulmonary circulation to sampling. Recently, this difficulty has been circumvented by combined catheterization of the right and left hearts, which allows calculation of pulmonary mean transit time from arterial dilution curves obtained by injection of label into the pulmonary artery and left atrium (1-4). The information thus obtained provides the best available estimate of pulmonary blood volume but is restricted to a relatively small group of patients.A different approach is provided by external counting techniques. Double-peaked curves, named radiocardiograms (5), are obtained by injecting a gamma-emitting label into either a peripheral vein, the right atrium, or the right ventricle, and monitoring its dilution in the cardiac cavities with a scintillation detector collimated over the precordium. It is possible, in most instances, to separate completely the right and left components of radiocardiograms; thus two dilution curves, respectively upstream and downstream to the pulmonary circulation, can be obtained (Figure 1). However, these precordial curves cannot be considered as ordinary dye-dilution curves, since their characteristics depend on the contributions of several circulatory sections. This is particularly true for the left component of radiocardiograms, which, with the type of collimator commonly used, is due, before the time of intracardiac recirculation,

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The Pulmonary Blood Volume in Man*

Cited by 125 publications

References 16 publications

Behavior of Normal Pulmonary Circulation during Changes of Total Blood Volume in Man*

Behavior of Normal Pulmonary Circulation during Changes of Total Blood Volume in Man*

Determinants of pulmonary blood volume

A Study of the Pulmonary Blood Volume in Man by Quantitative Radiocardiography*

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