Determinants of pulmonary blood volume

Lewis, Melvin; Gnoj, Julian; Fisher, Vincent J.; Christianson, Lynn C.

doi:10.1172/jci106216

Cited by 28 publications

(21 citation statements)

References 27 publications

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“…The peripheral vascular resistance index was expressed in arbitrary units derived from the ratio of mean arterial pressure to cardiac index. Previous stud ies [16,17] showed a close agreement between the values of cardiac output obtained with radiocardio graphy and those calculated from the simultaneously recorded arterial dilution curves.…”

Section: Hemodynamic Investigationsupporting

confidence: 63%

Chronic Hemodynamic Effects of Propranolol Treatment in Dialysis-Refractory Hypertension

Maggiore

Zoccali

Monzani

et al. 1978

Nephron

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The hemodynamic mechanism of the hypotensive effect of propranolol was studied by quantitative radiocardiography in 8 patients with dialysis-resistant hypertension. Propranolol treatment brought about a decrease in mean arterial pressure and peripheral vascular resistances. The cardiac index was slightly reduced only in the early stage of the treatment. No significant difference was found between patients on treatments lasting longer than 3 months and patients with dialysis-controlled hypertension. The results show that propranolol can be used safely as the sole antihypertensive agent in patients with dialysis-resistant hypertension.

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Section: Hemodynamic Investigationsupporting

confidence: 63%

Chronic Hemodynamic Effects of Propranolol Treatment in Dialysis-Refractory Hypertension

Maggiore

Zoccali

Monzani

et al. 1978

Nephron

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“…In a normal healthy person, it is estimated that the pulmonary blood volume is approximately 10% of the total blood volume of the body, with 20-25% being arterial blood volume [26,27,28]. This presents the opportunity for rapidly achieving a high drug concentration in the bloodstream, but also the challenge of avoiding unintended metabolism and clearance of a drug.…”

Section: Airways and Cellsmentioning

confidence: 99%

Targeting Inhaled Therapy beyond the Lungs

Mortensen

Hickey

2014

Respiration

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Pulmonary disease has been the primary target of inhaled therapeutics for over 50 years. During that period, increasing interest has arisen in the use of this route of administration to gain access to the systemic circulation for the treatment of a number of diseases beyond the airways. In order to effectively employ this route, the barriers to transport from the lungs following deposition of aerosols must be considered, including the nature of the disease (whether proximal, as in pulmonary hypertension, or distal, as in diabetes). Delivery to the systemic circulation begins with the efficiency of aerosol generation and subsequent deposition in the airways and proceeds to the influence of mechanisms of clearance, including absorption, metabolism, and mucociliary and cell-mediated transport, on the residence time of the drugs in the lungs. The nature of the drug (small or large molecules/low or high molecular weight), susceptibility to degradation and general physicochemical properties play a role in the chemistry of its formulation, physics of aerosol delivery and biology of disposition.

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“…tively dense, but not completely collapsed lung like the normal lung in the expiratory state. The most obvious difference between in vitro and in vivo is the amount of pulmonary blood filling: the typical human lung in vivo weighs between 800 and 1000 g [16] of which 400-600 ml (g) are blood [17,18]. The weight of blood-free and collapsed lungs at autopsy is about 480 g [19].…”

Section: The Physical Basis: the Sound Carriermentioning

confidence: 99%