The Psychological Impact of Coronavirus Disease 2019 on Patients Attending a Tertiary Healthcare Facility in Pakistan: A Cross-Sectional Study

Ali, Umar Abdul; Iftikhar, Nadia; Amat-ur-Rasool, Hafsa; Ahmed, Mehboob; Hafeez, Javeria; Carter, Wayne G.

doi:10.3390/healthcare10061049

Cited by 3 publications

(1 citation statement)

References 36 publications

(43 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The prevalence of mental illness was higher among hospitalized recovering COVID-19 patients as reported in a study from Pakistan that showed mild to very severe degrees of depression (43%), anxiety (52%), stress (42%), and PTSD (8%) [32]. In a study from Italy, including 479 patients who had recovered from COVID-19, symptoms of mental disorders and lack of focus/focus were reported in 10.2% and 20% of the sample, respectively [33].…”

Section: Discussionmentioning

confidence: 71%

Mental health of COVID-19 recovered individuals: A national study from Jordan

et al. 2023

View full text Add to dashboard Cite

Aim: To investigate the relationship between COVID-19 infection and subsequent long-term mental consequences among patients recovering from the disease. Methods: A cross-sectional and survey-based study was conducted in Jordan using Google Forms during the period from March to July of 2022. The requirement to participate was that individuals be at least 18 years old and have at least one symptomatic COVID-19 infection. A total of 2,055 subjects recruited in the study. Mental health was assessed using mental health inventory-38 (MHI-38). Results: Females represent 64.8% (n=1,182) of the sample. The mean age of the participants was 39.9±14.4 years. Subjects who recovered from COVID-19 scored slightly higher than moderate on different scales of MHI-38. These include anxiety, depression, loss of behavioral and emotional control, general positive affect, emotional ties, and life-satisfactions. The prevalence of depression among participants was 46.3% (n=952). The prevalence of anxiety among participants was 45.8% (n=942). The prevalence of loss of physical and emotional control was 47.2% (n=970). Multiple regression showed that employment status, tobacco use, and severe COVID-19 infection were associated with mental illness. Not working, using tobacco, and having severe COVID-19 infection were more likely to develop mental illness (p<0.01). Conclusion: Individuals who recover from COVID-19 are susceptible to developing mental illnesses. Factors associated with such susceptibility include employment status, tobacco use and severity of infection. The current findings can be used in mental health interventions targeting individuals who recovered from COVID-19.

show abstract

Section: Discussionmentioning

confidence: 71%

Mental health of COVID-19 recovered individuals: A national study from Jordan

et al. 2023

View full text Add to dashboard Cite

show abstract

Investigating posttraumatic stress disorder among COVID-19 recovered patients: A cross-sectional study

Sujan

Tasnim

Haghighathoseini

et al. 2023

Heliyon

View full text Add to dashboard Cite

The Potential of Stilbene Compounds to Inhibit Mpro Protease as a Natural Treatment Strategy for Coronavirus Disease-2019

Naseem

Rasool

Ahmed

et al. 2022

CIMB

View full text Add to dashboard Cite

COVID-19 disease has had a global impact on human health with increased levels of morbidity and mortality. There is an unmet need to design and produce effective antivirals to treat COVID-19. This study aimed to explore the potential ability of natural stilbenes to inhibit the Mpro protease, an acute respiratory syndrome coronavirus-2 (SARS-CoV-2) enzyme involved in viral replication. The binding affinities of stilbene compounds against Mpro were scrutinized using molecular docking, prime molecular mechanics-generalized Born surface area (MM-GBSA) energy calculations, and molecular dynamic simulations. Seven stilbene molecules were docked with Mpro and compared with GC376 and N3, antivirals with demonstrated efficacy against Mpro. Ligand binding efficiencies and polar and non-polar interactions between stilbene compounds and Mpro were analyzed. The binding affinities of astringin, isorhapontin, and piceatannol were −9.319, −8.166, and −6.291 kcal/mol, respectively, and higher than either GC376 or N3 at −6.976 and −6.345 kcal/mol, respectively. Prime MM-GBSA revealed that these stilbene compounds exhibited useful ligand efficacy and binding affinity to Mpro. Molecular dynamic simulation studies of astringin, isorhapontin, and piceatannol showed their stability at 300 K throughout the simulation time. Collectively, these results suggest that stilbenes such as astringin, isorhapontin, and piceatannol could provide useful natural inhibitors of Mpro and thereby act as novel treatments to limit SARS-CoV-2 replication.

show abstract

The Psychological Impact of Coronavirus Disease 2019 on Patients Attending a Tertiary Healthcare Facility in Pakistan: A Cross-Sectional Study

Cited by 3 publications

References 36 publications

Mental health of COVID-19 recovered individuals: A national study from Jordan

Mental health of COVID-19 recovered individuals: A national study from Jordan

Investigating posttraumatic stress disorder among COVID-19 recovered patients: A cross-sectional study

The Potential of Stilbene Compounds to Inhibit Mpro Protease as a Natural Treatment Strategy for Coronavirus Disease-2019

Contact Info

Product

Resources

About