The psoriasis-associated antigen, pso p27, is expressed by tryptase-positive cells in psoriatic lesions

Iversen, Ole‐Jan; Lysvand, Hilde; Jacobsen, Trond; Bergh, Kåre; Lie, Benedicte A.

doi:10.1007/bf00373437

Cited by 16 publications

(10 citation statements)

References 11 publications

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“…After these observations, several other investigators conWrmed that the number of mast cells is increased in the upper dermis of the psoriatic lesion [59,60,80,189], and it is the MC TC type of mast cells that are increased in number in the uppermost dermis of the psoriatic lesion [61]. However, this change is not speciWc to psoriasis since MC TC mast cells are similarly increased in number in superWcial spreading basal cell carcinoma [31], and mast cells in chronic leg ulcers are predominantly of this MC TC type [74].…”

Section: Mast Cells In the Psoriatic Lesionmentioning

confidence: 92%

Is there a role for mast cells in psoriasis?

et al. 2008

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Mast cells have traditionally been considered as eVector cells in allergy but during the last decade it has been realized that mast cells are essentially involved in the mechanisms of innate and acquired immunity. Upon activation by anaphylactic, piecemeal degranulation or degranulation-independent mechanisms mast cells can secrete rapidly or slowly a number of soluble mediators, such as serine proteinases, histamine, lipid-derived mediators, cytokines, chemokines and growth factors. Mast cells can express cell surface co-stimulatory receptors and ligands, and they can express MHC class II molecules and thereby present antigens. These soluble factors and cell surface molecules can interact with other cells, such as endothelial cells, keratinocytes, sensory nerves, neutrophils, T cell subsets and antigen presenting cells which are essential eVectors in the development of skin inXammation. Besides promoting inXammation, mast cells may attempt in some circumstances to suppress the inXammation and epidermal growth but the regulation between suppressive and proinXammatory mechanisms is unclear. Psoriasis is characterized by epidermal hyperplasia and chronic inXammation where tryptase-and chymase-positive MC TC mast cells are activated early in the developing lesion and later the cells increase in number in the upper dermis with concomitant expression of cytokines and TNF superfamily ligands as well as increased contacts with neuropeptide-containing sensory nerves. Due to the intimate involvement of mast cells in immunity and chronic inXammation the role of mast cells in psoriasis is discussed in this review.

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Section: Mast Cells In the Psoriatic Lesionmentioning

confidence: 92%

Is there a role for mast cells in psoriasis?

et al. 2008

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“…The Pso p27 antigen is produced by mast cells in psoriatic lesions while tryptase positive cells in uninvolved skin are negative with respect to Pso p27 (Iversen et al, 1995). The expression of Pso p27 is restricted to skin lesions and the antigen has not been detected in uninvolved psoriatic skin or skin biopsies from healthy controls (Iversen et al, 1995). The psoriasis-associated antigen, Pso p27, can be isolated from psoriasis scale and is present as complement-activating immune complexes (Rødahl et al, 1988;Song et al, 2009).…”

Section: Introductionmentioning

confidence: 94%

“…The synthesis of this Pso p27 is suppressed at the same time as the skin lesions go into remission (Iversen et al, 1995), and treatment with Cyclosporin A has demonstrated a positive correlation between expression of Pso p27 and disease activity (Dalaker et al, 1999).…”

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 97%

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Expression of the psoriasis-associated antigen, Pso p27, is inhibited by Traditional Chinese Medicine

Song

Lysvand

Yan

et al. 2010

Journal of Ethnopharmacology

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“…We have focused attention on pso p27 which is a major antigen isolated from psoriatic lesions [5]. The antigen is expressed in mast cells, and sequencing this protein has revealed no identity to proteins sequenced thus far [6,7]. The psoriasis-associated antigen pso p27 has been shown to participate in complement-activating immune complexes in psoriatic lesions and in serum from patients with psoriasis [8].…”

Section: Introductionmentioning

confidence: 99%

Effects of Cascade Apheresis in Patients with Psoriasis and Psoriatic Arthropathy

Jørstad

Bergh²,

Iversen³

et al. 1998

Blood Purif

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Eight patients with psoriasis, all with skin scales and 7 with disabling psoriatic arthritis, were subjected to cascade apheresis starting with three treatments per week for 2 weeks, followed by one treatment a week, comprising ten treatments in all. Six out of 7 patients (86%) with arthropathy and 3 out of 8 patients (38%) with scales experienced a beneficial effect. There was a large drop in the levels of circulating immune complexes (CIC) due to the treatment, and the removal of CIC was followed by reduced inflammatory activity in skin lesions and joints as evaluated by pain, morning stiffness, grip strength, plaque score, and PASI index. However, there was no correlation between the level of CIC, disease activity, or treatment response. From the present results it is concluded that CIC may play a more significant role regarding psoriatic arthropathy than in skin manifestations, and apheresis may be beneficial in patients not responding to conventional therapy.

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The psoriasis-associated antigen, pso p27, is expressed by tryptase-positive cells in psoriatic lesions

Cited by 16 publications

References 11 publications

Is there a role for mast cells in psoriasis?

Is there a role for mast cells in psoriasis?

Expression of the psoriasis-associated antigen, Pso p27, is inhibited by Traditional Chinese Medicine

Effects of Cascade Apheresis in Patients with Psoriasis and Psoriatic Arthropathy

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