The Protective Role of Septilin Against Gamma Radiation-Induced Testicular Toxicity in Rats

Eissa, Omaima S.; Moustafa, Nehal A.

doi:10.21608/ejhm.2007.17720

Cited by 4 publications

(2 citation statements)

References 11 publications

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“…It consists of the extracts from medicinal plants such as, Maharasanadi qoath (130mg), Tinospora cordifolia, (98mg), Rubia cordifolia (64mg), Emblica officinalis (32mg), Moringa pterigosperma (32mg), Glycyrrhiza glabra (12mg) and the powders of Balsamodendron mukul (0.324mg) and Shankha bhasma (64mg) [11]. In traditional medicine, Spt is used as an antibacterial, anti-inflammatory and im munomodulatory agent [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Septilin, A Polyherbal Formulation Against the Immunosuppression Induced by Cyclophosphamide and Cisplatin in Swiss Albino Mice

Sd¹,

Shenoy

2022

IJT

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Background: Septilin (Spt) is an ayurvedic drug formulation from Himalaya Drug Company and is well-known for its antibacterial, anti-inflammatory and immunomodulatory activities. Interest in the use of medicinal plants and herbal medicine as immunomodulators has currently been the subject of scientific investigation worldwide. Cyclophosphamide (CP) and Cisplatin (Csp) are widely used chemotherapeutic drugs and are known for their immunosuppressive effects. Methods: The present study evaluated the immune-stimulating activity of Spt (125, 250 and 500 mg/kg; PO/7 days) against CP (50 mg/kg) and Csp (10 mg/kg) induced immunosuppression in mice sensitized with sheep Red Blood Cells (RBC) by measuring Hemagglutination Antibody (HA) titre values and by determining the haematological parameters, such as Haemoglobin (Hb) content, White Blood Cells (WBC), RBC and platelet counts. Thymus index and differential counts of leukocytes were also determined. Results: Upon HA assay, the titre was significantly decreased in CP (59.40%) and Csp (62.16%) in the treatment groups (P<0.001). An increase in the HA titre value in Spt-treated mice showed the stimulation of humoral immune response (P<0.001). The results of haematological study in Spt-treated mice indicated stimulation of total leukocytes, RBC and platelet counts. Moreover, Spt treatment prior to the administration of CP and Csp prevented the loss of body weight and minimized their adverse effect on the mice thymus. Conclusion: Our experimental evidence suggests the immunostimulatory potency of Spt against the immunosuppression induced by chemotherapeutic drugs in mice. The study results are comparable with the immune-potentiating effects of standard immunomodulatory drug Levamisole (Lev). Hence, Spt may be used as an adjuvant to obviate the immune suppression induced by chemotherapeutic medications.

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Section: Introductionmentioning

confidence: 99%

Septilin, A Polyherbal Formulation Against the Immunosuppression Induced by Cyclophosphamide and Cisplatin in Swiss Albino Mice

Sd¹,

Shenoy

2022

IJT

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“…The effect of gamma ray on testicular organs of rats resulted in a reduction in the value of spermatogenic cells (Eissa et al, 2007). High doses of radiation can be lethal.…”

Section: Introductionmentioning

confidence: 99%

COMPARATIVE RADIOPATHOLOGY OF MALE REPRODUCTIVE ORGANS IN SPRAGUE DAWLEY RATS ADMINISTERED WITHCurcuma longaANDOcimum sanctumAGAINST ACUTE GAMMA IRRADIATION

Thapru

Nair

Hoque

et al. 2022

Preprint

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The study was designed to evaluate the deleterious effects of acute lethal gamma irradiation on male reproductive organs of Sprague Dawley rats and the radioprotective potential by Curcuma longa and Ocimum sanctum in a experimental set up. Twenty five Male Spraque Dawley rats were taken and randomized into 5 groups (T1, T2, T3, T4, T5), Each group containing 5 animals. The groups were named as Group T1 (Negative Control), Group T2 (irradiation positive control), Group T3 (irradiation and Curcuma longa), Group T4 (irradiation and Ocimum sanctum), Group T5 (irradiation, Curcuma longa and Ocimum sanctum). The rats in groups T1 and T2 were given a daily dosage of normal saline for 14 days. Group T3 and T4 rats received aqueous extracts of Curcuma longa (40 mg/kg) and Ocimum sanctum (40 mg/kg), respectively, whereas group T5 rats received a combination of aqueous extracts of Curcuma longa (40 mg/kg) and Ocimum sanctum (40 mg/kg) for 14 days, prior to gamma irradiation. Animals of group T2, T3, T4, T5 were irradiated with 10 Gy of γ radiation on 15th day. Exposure of animals to 10 Gy gamma radiation resulted in significant decrease in body weight and testicular weight. Histopathological observations revealed testicular degenerative changes in the seminiferous tubules with primary spermatocytes being most affected and epididymis showed decreased spermatids density with cell debris in the lumen. Pretreatment with Curcuma longa at 40mg/kg for 14 days alleviated the radiation induced pathological changes in testis and epididymis. Curcuma longa demonstrated much better protective effect in combination with Ocimum sanctum in alleviating the radio pathological changes showing the possibility of synergistic effect. However, administration of Ocimum sanctum alone at 40mg/kg for 14 days did not reveal any significant radioprotective property after histomorphological evaluation. Gamma irradiation of 10 Gy induces severe radio pathological damage to organs of male reproductive system of Spraque Dawley rats. Pretreatment with Curcuma longa prior to radiotherapy may be effective in preventing radiation induced damage in the male reproductive organs. Better radioprotection can be achieved with the combination of Curcuma longa and Ocimum sanctum than using alone.

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Correlation between expression of CatSper1,2 and sperm parameters in the gamma irradiated adult mouse testis

Mohammadi

Kianmehr

Mohammadi

et al. 2019

International Journal of Radiation Biology

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The Protective Role of Septilin Against Gamma Radiation-Induced Testicular Toxicity in Rats

Cited by 4 publications

References 11 publications

Septilin, A Polyherbal Formulation Against the Immunosuppression Induced by Cyclophosphamide and Cisplatin in Swiss Albino Mice

Septilin, A Polyherbal Formulation Against the Immunosuppression Induced by Cyclophosphamide and Cisplatin in Swiss Albino Mice

COMPARATIVE RADIOPATHOLOGY OF MALE REPRODUCTIVE ORGANS IN SPRAGUE DAWLEY RATS ADMINISTERED WITHCurcuma longaANDOcimum sanctumAGAINST ACUTE GAMMA IRRADIATION

Correlation between expression of CatSper1,2 and sperm parameters in the gamma irradiated adult mouse testis

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