Correlation between expression of CatSper1,2 and sperm parameters in the gamma irradiated adult mouse testis

Mohammadi, Shabnam; Kianmehr, Mojtaba; Mohammadi, Maryam; Fahimian, Zahra; Karimimanesh, Elham; Farazifar, Mostafa; Nakhaei, Zahra; Golamneghad, Nafiseh; Bolourifard, Basir; Gholamin, Mehran; Mansouri, Atena; M, Reyhaneh Sadat Mahmoodi; Soleymanifard, Shokouhozaman; Boroumand-Noughabi, Samaneh; Ghandy, Nasibeh; Delshad, Ali; Mohammadzadeh, Fatemeh; Norasteh, Hojjat; Ghayour‐Mobarhan, Majid; Ferns, Gordon A.

doi:10.1080/09553002.2019.1552372

Cited by 5 publications

(2 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies conducted in people exposed to radiations from the atomic bombings of Hiroshima and Nagasaki [79] and the Chernobyl incident [80] have revealed poor motility in the spermatozoa of ejaculates from these men. Even though the mechanism behind the radiation-induced defective sperm motility is not clearly elucidated yet, significant reduction in the expression of cation channel of sperm associated1 (CatSper1) and cation channel of sperm associated2 (CatSper2) genes [81], and other sperm motility-associated proteins were observed in mice [82]. Kesari et al [83] reported that as low as 850 MHz of non-ionizing radiation impaired sperm motility in human.…”

Section: Radiationmentioning

confidence: 99%

Current Insights and Latest Updates in Sperm Motility and Associated Applications in Assisted Reproduction

et al. 2020

View full text Add to dashboard Cite

Spermatozoon is a motile cell with a special ability to travel through the woman’s reproductive tract and fertilize an oocyte. To reach and penetrate the oocyte, spermatozoa should possess progressive motility. Therefore, motility is an important parameter during both natural and assisted conception. The global trend of progressive reduction in the number and motility of healthy spermatozoa in the ejaculate is associated with increased risk of infertility. Therefore, developing approaches for maintaining or enhancing human sperm motility has been an important area of investigation. In this review we discuss the physiology of sperm, molecular pathways regulating sperm motility, risk factors affecting sperm motility, and the role of sperm motility in fertility outcomes. In addition, we discuss various pharmacological agents and biomolecules that can enhance sperm motility in vitro and in vivo conditions to improve assisted reproductive technology (ART) outcomes. This article opens dialogs to help toxicologists, clinicians, andrologists, and embryologists in understanding the mechanism of factors influencing sperm motility and various management strategies to improve treatment outcomes.

show abstract

Section: Radiationmentioning

confidence: 99%

Current Insights and Latest Updates in Sperm Motility and Associated Applications in Assisted Reproduction

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The epididymis of rats were cut into small slices in the pHam’s F-10 culture medium and incubated at 37℃ for half an hour [ 20 ] to release the spermatozoa into medium. In order to minimize the damage, we use microsurgical scissors to gently cut the epididymal epidermis to avoid damaging the subepidermal tissue of epididymis.…”

Section: Methodsmentioning

confidence: 99%

Qiangjing tablets repair of blood-testis barrier dysfunction in rats via regulating oxidative stress and p38 MAPK pathway

You

Zhang

et al. 2022

BMC Complement Med Ther

View full text Add to dashboard Cite

Background The blood-testis barrier (BTB) is a physical barrier of the testis to prevent various exogenous substrates from entering apical compartments and provides immune privilege for spermatogenesis, which is essential for normal spermatogenic function of testis. It has been shown that oxidative stress can damage BTB by activating the p38 MAPK pathway. In Traditional Chinese Medicine, Qiangjing tablets (QJT) improve spermatogenesis and increase pregnancy rates. Previous studies have confirmed that QJT can improve sperm quality and have obvious antioxidant effects. In this study, we explore whether QJT contributes to recovery from BTB dysfunction in rats. Methods BTB dysfunction was induced in rats by 1% Cyclophosphamide (CP). The CP-induced rats in the treatment group were given a dose of QJT (0.45 g/kg·d) by gavage. Testis tissues were collected for histopathological and biochemical analysis, and the testis weight was estimated. Levels of BTB-related proteins and antioxidant enzyme were analyzed in the testis tissues. Results QJT resolved the pathological injury of rats testis induced by CP. Furthermore, MDA levels were significantly reduced, and the levels of SOD markedly increased in the testicular tissue after QJT treatment. In addition, QJT down-regulated the expression of p38 protein in rat testis and up-regulated the expressions of key proteins ZO-1, occludin and F-actin in BTB. Conclusion These results demonstrate that QJT exerts protective effects on CP-induced rats with BTB dysfunction, likely by regulating the oxidative stress-mediated p38 MAPK pathway.

show abstract

Radiation and male reproductive system: Damage and protection

Guo,

Wang,

Shuai

et al. 2024

Chemosphere

View full text Add to dashboard Cite

Correlation between expression of CatSper1,2 and sperm parameters in the gamma irradiated adult mouse testis

Cited by 5 publications

References 20 publications

Current Insights and Latest Updates in Sperm Motility and Associated Applications in Assisted Reproduction

Current Insights and Latest Updates in Sperm Motility and Associated Applications in Assisted Reproduction

Qiangjing tablets repair of blood-testis barrier dysfunction in rats via regulating oxidative stress and p38 MAPK pathway

Radiation and male reproductive system: Damage and protection

Contact Info

Product

Resources

About