The protective role of ginsenoside compound K in porcine oocyte meiotic maturation failed caused by benzo(a)pyrene during in vitro maturation

Luo, Zhao‐Bo; Rahman, Saeed Ur; Xuan, Mei‐Fu; Han, Sheng-Zhong; Li, Zhou-Yan; Yin, Xi‐Jun; Kang, Jin‐Dan

doi:10.1016/j.theriogenology.2020.07.006

Cited by 7 publications

(6 citation statements)

References 44 publications

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“…Unexpectedly, we observed that female mouse exposure to BaP even led to a reduction in oocyte meiotic maturation and early embryonic development in the resulting offspring (Sui et al, 2020). Although BaP is a toxicant to oocytes, certain chemicals, such as melatonin and ginsenoside compound K, might prevent oocytes from BaP exposure-mediated defects (Miao et al, 2018;Luo et al, 2020).…”

Section: Introductionmentioning

confidence: 76%

“…In this study, MV treatment reduced ROS levels in oocytes of BaP-exposed mice and thus avoided the induction of oxidative stress. A previous study revealed that melatonin and ginsenoside compound K can attenuate oxidative stress to protect porcine oocytes from meiotic defects caused by BaP exposure (Miao et al, 2018;Luo et al, 2020). In addition, we recently reported that MV inhibits the increase in ROS levels in porcine oocytes exposed to LPS (Yan et al, 2021).…”

Section: Discussionmentioning

confidence: 93%

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Mogroside V Alleviates Oocyte Meiotic Defects and Quality Deterioration in Benzo(a)pyrene-Exposed Mice

et al. 2021

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Accumulating evidence has demonstrated that benzo(a)pyrene (BaP) exposure adversely affects female reproduction, especially oocyte meiotic maturation and subsequent embryo development. Although we previously found that mogroside V (MV), a major bioactive component of S. grosvenorii, can protect oocytes from quality deterioration caused by certain stresses, whether MV can alleviate BaP exposure-mediated oocyte meiotic defects remains unknown. In this study, female mice were exposed to BaP and treated concomitantly with MV by gavage. We found that BaP exposure reduced the oocyte maturation rate and blastocyst formation rate, which was associated with increased abnormalities in spindle formation and chromosome alignment, reduced acetylated tubulin levels, damaged actin polymerization and reduced Juno levels, indicating that BaP exposure results in oocyte nucleic and cytoplasmic damage. Interestingly, MV treatment significantly alleviated all the BaP exposure-mediated defects mentioned above, indicating that MV can protect oocytes from BaP exposure-mediated nucleic and cytoplasmic damage. Additionally, BaP exposure increased intracellular ROS levels, meanwhile induced DNA damage and early apoptosis in oocytes, but MV treatment ameliorated these defective parameters, therefore it is possible that MV restored BaP-mediated oocyte defects by reducing oxidative stress. In summary, our findings demonstrate that MV might alleviate oocyte meiotic defects and quality deterioration in BaP-exposed mice.

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Section: Introductionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 93%

Mogroside V Alleviates Oocyte Meiotic Defects and Quality Deterioration in Benzo(a)pyrene-Exposed Mice

et al. 2021

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“…In addition, studies have demonstrated that the mitochondrial membrane potential is decreased in bovine oocytes exposed to 41°C (Ascari et al, 2017; Soto & Smith, 2009). The addition of ginsenoside CK enhanced porcine oocyte maturation and subsequent embryonic development in vitro through its antioxidant activity and thereby increased mitochondrial function (Luo et al, 2020). Therefore, we hypothesize that GRe effectively promotes the recovery of mitochondrial function.…”

Section: Discussionmentioning

confidence: 99%

Presence of ginsenoside re during in vitro maturation protects porcine oocytes from heat stress

Liu

Duan

et al. 2022

Reprod Domestic Animals

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Heat stress (HS) affects the development of porcine gametes and embryos negatively, induces the decrease of reproductive ability significantly, threatens global pig production. Ginsenoside Re (GRe), is a main bioactive component of ginseng, shows very specific anti‐apoptotic, antioxidant and anti‐inflammatory activities. To investigate the alleviating effect of GRe on the in vitro maturation of porcine oocyte under the HS, the polar body extrusion rate, intracellular levels of reactive oxygen species (ROS) and glutathione (GSH), ATP content, mitochondrial membrane potential (MMP) were assessed. For the current study, porcine cumulus‐oocyte complexes (COCs) randomly divided into four groups: the control, GRe, HS and HS + GRe group. The results showed that HS inhibited the cumulus cell expansion and polar body extrusion rate, the levels of GSH and MMP, the ATP content, the gene expression of Nrf2 of porcine oocytes and the parthenogenetic activation (PA) embryo development competence, but GRe treatment could partly neutralize these adverse effects. Furthermore, HS increased the ROS formation and percentage of apoptosis, the gene expression of HSP90, CASP3 and CytoC of porcine oocytes, but GRe could weaken the effect on Cyto C and BAX expression induced by HS. Taken together, these results showed that the presence of GRe during in vitro maturation protects porcine oocytes from HS. These findings lay a foundation for GRe may be used as a potential protective drug to protect porcine oocytes against HS damage.

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“…Similar to Tris DBA, compound K could also alleviate IgAN. Compound K is a fundamental bioactive component of ginseng that has anti-inflammatory, anti-apoptosis and antioxidant activities [ 71 , 72 ]. Chung-Yao Wu et al demonstrated that compound K inhibited NLRP3 inflammasome activation by promoting sirtuin1-dependent autophagy in an IgAN model, which improved IgAN.…”

Section: The Interplay Between Autophagy and Nlrp3 Inflammasome In Iga Nephropathymentioning

confidence: 99%

The Complex Interplay between Autophagy and NLRP3 Inflammasome in Renal Diseases

Ding

Liu

et al. 2021

IJMS

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Autophagy is a highly conserved process of the eukaryotic cell cycle. It plays an important role in the survival and maintenance of cells by degrading organelles, proteins, and macromolecules in the cytoplasm and the circulation of degraded products. The dysfunction of autophagy can lead to the pathology of many human diseases. The nucleotide-binding oligomerization domain-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome belongs to the family of nucleotide-binding and oligomerization domain-like receptors (NLRs) and can induce caspase-1 activation, thus leading to the maturation and secretion of interleukin-1beta (IL-1β) and IL-18. It has been reported that the interplay between autophagy and NLRP3 inflammasome is involved in many diseases, including renal diseases. In this review, the interplay between autophagy and the NLRP3 inflammasome and the mechanisms in renal diseases are explored to provide ideas for relevant basic research in the future.

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The protective role of ginsenoside compound K in porcine oocyte meiotic maturation failed caused by benzo(a)pyrene during in vitro maturation

Cited by 7 publications

References 44 publications

Mogroside V Alleviates Oocyte Meiotic Defects and Quality Deterioration in Benzo(a)pyrene-Exposed Mice

Mogroside V Alleviates Oocyte Meiotic Defects and Quality Deterioration in Benzo(a)pyrene-Exposed Mice

Presence of ginsenoside re during in vitro maturation protects porcine oocytes from heat stress

The Complex Interplay between Autophagy and NLRP3 Inflammasome in Renal Diseases

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