The protective effects of vitamin E against selenium-induced oxidative damage and hepatotoxicity in rats

Abstract

Selenium is a trace element which can be toxic when consumed at high levels. The study was conducted to assess the possible protective role of vitamin E against selenosis in rats. Selenium was applied at different single doses (4.5, 9 and 18 mg/kg b.wt.). Vitamin E (200 mg/kg b.wt.) was given to the rats one hour before treatment with the higher selenium dose. In seleniumtreated rats, selenosis was evident from the elevated level of malondialdehyde. Oxidative stress was induced from the significant altered activity levels of CAT, SOD and GPx. Furthermore, selenium-induced hepatotoxicity was developed, where the activity levels of AST, ALT and GGT were significantly increased. Hepatotoxicity was also manifested histologically. Pretreatment with vitamin E significantly alleviated the affected levels of the investigated parameters, and counteracted the hepatic histopathological changes. The results demonstrate that vitamin E supplementation provides an effective protection against oxidative damage and hepatotoxicity induced by selenosis.

The Effect of Maternal Dietary Selenium Supplementation on Blood Antioxidant and Metabolic Status of Ewes and Their Lambs

“…Selenium supplementation in the present study resulted in a significant decrease in the activity of the enzymes AST and GGT. Liver enzymes, especially AST, ALT, and GGT, are commonly used to assess liver health or as indicators of liver damage and as a response to toxins [ 64 ]. Increased activity of the above enzymes is observed in animals treated with high doses of selenium over a longer period of time [ 46 ].…”

The Toxic Effect of Selenium in Hepato-renal Aspects of Adult Male Rats Exposed to Myoqinon: A physiological, Histopathological, and Biochemical Investigation

“…As a result, that selenium (SSe) could cause damage and/or oxidative stress in hepatic cells, performance the liver incapable of performing its functions [15,22]. The Reactive Oxygen Species (ROS) are well recognized to play a major role in or (SGOT) and (ALP) activity in the blood is key signs as biomarkers of liver dysfunction [1]. The current results were indicated of concentration the Total serum Bilirubin (TB) that had a significant elevation in the (W2 and W3 Groups) as compared to the (W1 and W4 Groups) from the investigation.…”

“…Selenium (Se) is a trace mineral that if administered in excessive quantities, will be toxic [1]. Selenium may be present in the soil, plants, rocks, and water, among other agroecosystem components [2].…”

Dietary Micronutrients from Zygote to Senility: Updated Review of Minerals’ Role and Orchestration in Human Nutrition throughout Life Cycle with Sex Differences

“…Excess accumulation of selenium has been linked to hepatic necrosis, and cardiac muscle dystrophy [20]. In pigs, acute selenosis develops after an high dietary consumption of more than 20 mg per kg of body weight of the element selenium [21]. Chronic selenosis develops after consuming diets containing 5-20 ppm selenium for an extended period of time in pigs [21].…”

“…In pigs, acute selenosis develops after an high dietary consumption of more than 20 mg per kg of body weight of the element selenium [21]. Chronic selenosis develops after consuming diets containing 5-20 ppm selenium for an extended period of time in pigs [21]. Selenium poisoning is characterized by symptoms such as blindness, stiffness of the bone, severe anemia and hair loss [22], more likely to exist in regions with extremely high selenium levels above average and in individuals that consume up to 5 mg per day or from atmospheric inhalation of as much as 0.2 mg/m 3 [23].…”