The Toxic Effect of Selenium in Hepato-renal Aspects of Adult Male Rats Exposed to Myoqinon: A physiological, Histopathological, and Biochemical Investigation

Abstract

T HE CURRENT research aimed to investigate the oxidative stress induced by selenium (Sodium-Selenite Na 2 SeO 3 ) and hepato-renal influences in adult male Wistar rats exposed to myoqinon (Mq). Thirty-two adult male Wistar rats were sectioned into four groups (eight Wistar rats/group) and treated daily for forty-four consecutive days as follows: The first group(W1, control group) obtained the tap water plus intubated Dimethyl Sulfoxide(1%), the second group(W2)obtained 4.8 ppm selenium (SSe)was drenched in the tap water, the third group(W3)obtained 4.8 ppm selenium(SSe) was drenched in the tap water plus intubated every day with myoqinon (Mq) at a dose of 10 mg/kg B.W, whilst the fourth group(W4)of rats was intubated with myoqinon (Mq) only at a dose of 10 mg/kg B.W. Blood samples were taken of fasting Wistar rats at (0,23, and 44 days) of the experiment and then the determination of Total Serum Protein (TSP) concentrations, albumin levels, serum (SGPT) activity, serum (SGOT) activity, serum Alkaline Phosphatase (ALP), serum Total Bilirubin (TB), globulin, Creatinine (Cr) serum, Blood Urea Nitrogen (BUN), peroxynitrite radicals concentrations, and serum Catalase (Cat) activity concentration. At the finish of the study sections from the liver and kidney were obtained for histopathological examination. It was concluded that the findings of the study demonstrated the toxic effect of selenium (SSe) on the hepato-renal at a dosage of 4.8 ppm in adult male Wistar rats exposed to myoqinon (Mq) that was played the protective role as an antioxidant.

Effects of Quercetin on Codeine-Induced Reproductive Hormone Disorder

“…Control set: The control set(Con) consisted of adult male rats given standard tap water and dimethyl sulfoxide (DMSO 1%) orally by gavage needle and set(Q1) was intubated with quercetin at a dosage of (300mg/kg B.W.) only dissolved in 1% DMSO, set(Q2): codeine was given to rats in the laboratory daily at 50 mg/kg [23,24,19]. Furthermore, set(Q3) was intubated daily with quercetin (300 mg/kg body weight) in addition to receiving daily intubation with codeine (50mg/kg body weight).…”