The protective and therapeutic effect of phenoxy-2-methyl-2-propionic acid on experimental fatty liver in rats

Gümüş, Ümmügülsüm; Şennazlı, Gülbin; Bakırel, Utku

doi:10.3906/vet-1212-28

Turk J Vet Anim Sci

2013

DOI: 10.3906/vet-1212-28

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The protective and therapeutic effect of phenoxy-2-methyl-2-propionic acid on experimental fatty liver in rats

Ümmügülsüm Gümüş¹,

Gülbin Şennazlı²,

Utku Bakırel³

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Cited by 2 publications

References 15 publications

(17 reference statements)

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Mefepronic acid is associated with a decrease in serum liver enzyme activities in dogs with suspected hepatopathy

Quintavalla

Gelsi²,

Battaglia³

et al. 2021

Veterinary Medicine & Sci

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Although suspected hepatopathy in dogs can be assessed by the blood levels of both liver enzyme activities and functional liver parameters, very often the precise diagnosis of primary or secondary hepatobiliary diseases can remain uncertain. Therefore, in a number of patients, the therapeutic intervention has the purpose of slowing the progression of fibrosis and provide for optimal hepatic support. Recently the PPARs (peroxisome proliferator‐activated receptors) have been identified as a family of hepatic nuclear hormonal receptors, involved in the regulation of lipid and glucose metabolism. The aim of this work is to assess the effect of mefepronic acid (PMPA), a PPAR agonist, on liver enzyme markers in blood samples of dogs with suspected hepatopathies. Twenty dogs, with suspected hepatopathies, were divided into two groups: ten of them received subcutaneously daily 10 mg/kg of PMPA for 7 days (treated, group T), while the remaining dogs were treated with a conventional supportive treatment for hepatopathies consisting of ursodeoxycholic acid (UDCA) 10 mg/kg PO SID for 45 days (control, group C). PMPA yielded a faster decrease in liver enzyme activities compared to UDCA, that in most cases was maintained after the suspension of the treatment. These data suggest that PMPA might be considered as supportive treatment for dogs with suspected hepatopathy.

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Mefepronic acid is associated with a decrease in serum liver enzyme activities in dogs with suspected hepatopathy

Quintavalla

Gelsi²,

Battaglia³

et al. 2021

Veterinary Medicine & Sci

View full text Add to dashboard Cite

show abstract

Comparing the effects of treatment with ammonium molybdate versus ammonium molybdate and phenoxy-2-methyl-2-propionic acid on liver functions in natural copper poisoning of sheep

Mecitoğlu

Topal

Kaçar

et al. 2017

Small Ruminant Research

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The protective and therapeutic effect of phenoxy-2-methyl-2-propionic acid on experimental fatty liver in rats

Cited by 2 publications

References 15 publications

Mefepronic acid is associated with a decrease in serum liver enzyme activities in dogs with suspected hepatopathy

Mefepronic acid is associated with a decrease in serum liver enzyme activities in dogs with suspected hepatopathy

Comparing the effects of treatment with ammonium molybdate versus ammonium molybdate and phenoxy-2-methyl-2-propionic acid on liver functions in natural copper poisoning of sheep

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