The prospects of nanotherapeutic approaches for targeting tumor-associated macrophages in oral cancer

Bhattacharya, Debapriya; Sakhare, Kalyani; Narayan, Kumar Pranav; Banerjee, Rajkumar

doi:10.1016/j.nano.2021.102371

Cited by 7 publications

(2 citation statements)

References 180 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Immunotherapy targeting TAMs has become a potential strategy for anti-tumor therapy based on the tumor-promoting mechanism of TAMs. Many treatments targeting TAMs have shown good results in preclinical studies ( Bhattacharya et al, 2021 ). Also, the combination of TAMs-targeting with traditional therapies has also achieved good results ( Dai et al, 2020b ).…”

Section: Immunotherapy Targeting Tumor-associated Macrophagesmentioning

confidence: 99%

The role of tumor-associated macrophages in oral squamous cell carcinoma

et al. 2022

View full text Add to dashboard Cite

Oral squamous cell carcinoma (OSCC) is a common head and neck cancer with a high recurrence rate and a low 5-year survival rate. Tumor-associated macrophages (TAMs) are important immune cells in the tumor microenvironment, which play an important role in the progression of many tumors. This article reviews the origin, and the role of TAMs in the invasion, metastasis, angiogenesis and immunosuppression of OSCC. Therapeutic strategies targeting TAMs are also discussed in hopes of providing new ideas for the treatment of OSCC.

show abstract

Section: Immunotherapy Targeting Tumor-associated Macrophagesmentioning

confidence: 99%

The role of tumor-associated macrophages in oral squamous cell carcinoma

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Compared with their early counterparts, patients with OSCC in stage III/IV had a significantly poor prognosis and 5-year survival rates less than 30% due to recurrence and metastasis [4]. In addition, despite progress in the available treatments for advanced OSCC [5][6][7][8], the 5-year survival rate has not improved significantly during the past decades. Therefore, it is a major concern to explore the potential mechanism of recurrence and metastasis of OSCC.…”

Section: Introductionmentioning

confidence: 99%

The Roles of Exosomes in the Diagnose, Development and Therapeutic Resistance of Oral Squamous Cell Carcinoma

Shi

Jia

2023

IJMS

View full text Add to dashboard Cite

Oral cancer is one of the most common cancers worldwide, of which more than half of patients are diagnosed at a locally advanced stage with poor prognosis due to recurrence, metastasis and resistant to treatment. Thus, it is imperative to further explore the potential mechanism of development and drug resistance of oral cancer. Exosomes are small endosome-derived lipid nanoparticles that are released by cells. Since the cargoes of exosomes were inherited from their donor cells, the cargo profiles of exosomes can well recapitulate that of their donor cells. This is the theoretical basis of exosome-based liquid biopsy, providing a tool for early diagnosis of oral cancer. As an important intracellular bioactive cargo delivery vector, exosomes play a critical role in the development of oral cancer by transferring their cargoes to receipt cells. More importantly, recent studies have revealed that exosomes could induce therapy-resistance in oral cancer through multiple ways, including exosome-mediated drug efflux. In this review, we summarize and compare the role of exosomes in the diagnosis, development and therapy-resistant of oral cancer. We also highlight the clinical application of exosomes, and discuss the advantages and challenges of exosomes serving as predictive biomarker, therapy target and therapy vector in oral cancer.

show abstract

Bionanotechnological Strategies and Tools for Cancer Prediction, Prevention and Therapy

Narayan

2024

Molecular Biomarkers for Cancer Diagnosis and Therapy

View full text Add to dashboard Cite

The prospects of nanotherapeutic approaches for targeting tumor-associated macrophages in oral cancer

Cited by 7 publications

References 180 publications

The role of tumor-associated macrophages in oral squamous cell carcinoma

The role of tumor-associated macrophages in oral squamous cell carcinoma

The Roles of Exosomes in the Diagnose, Development and Therapeutic Resistance of Oral Squamous Cell Carcinoma

Bionanotechnological Strategies and Tools for Cancer Prediction, Prevention and Therapy

Contact Info

Product

Resources

About