The role of tumor-associated macrophages in oral squamous cell carcinoma

Xue, Yiwen; Song, Xiaohong; Fan, Siyu; Deng, Runzhi

doi:10.3389/fphys.2022.959747

Cited by 20 publications

(20 citation statements)

References 88 publications

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“…The potential roles of T cells and macrophages in antitumor responses have been well-determined in many previous studies. In some human cancers, negative correlations have been reported between the number of infiltrating T cells and macrophages and the histological severity of the tumor [ 9 , 18 , 27 ]. A decrease in T cells in the mucous stroma has been reported [ 24 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

Histologic, immunohistochemical, and <i>in situ</i> hybridization study of myxoid stroma in feline oral squamous cell carcinoma

MINESHIGE,

TANAKA,

WATANABE

et al. 2024

The Journal of Veterinary Medical Science

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Oral squamous cell carcinoma (oSCC) is a highly invasive malignant neoplasm in cats. Recently, tumor stroma, known as tumor microenvironments, have been considered to play an essential role in tumor progression. However, their role in feline squamous cell carcinoma (SCC) remains unclear. This study aimed to reveal the cancer microenvironment of feline oSCC and evaluate the pathological mechanisms of progression. We used 19 samples from 17 cats with oSCC, which were examined using light microscopy, immunohistochemistry, and in situ hybridization (RNAscope ® ). Feline oSCCs had two types of stroma, namely fibrotic and myxoid stromal reaction patterns, which were easily distinguished using hematoxylin–eosin staining. The myxoid stroma was rich in hyaluronic acid, which seems to be produced by neoplastic cells. Furthermore, the presence of myxoid stroma was correlated with histological parameters, including the appearance of cancer-associated fibroblasts and tumor budding. Periostin protein expression was also frequently observed in the stroma of feline oSCC and was significantly more common in the myxoid stromal reaction pattern group than in the fibrotic group. Positive signals for periostin mRNA were detected in stromal cancer-associated fibroblasts. This study indicates that the interaction between neoplastic cells and stromal reaction pattern components, such as hyaluronic acid and periostin, may be involved in tumor malignancy. Therefore, we propose that focus be placed not only on the tumor tissue but also on the characterization of the stroma for analyzing feline oSCC.

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Section: Discussionmentioning

confidence: 99%

Histologic, immunohistochemical, and <i>in situ</i> hybridization study of myxoid stroma in feline oral squamous cell carcinoma

MINESHIGE,

TANAKA,

WATANABE

et al. 2024

The Journal of Veterinary Medical Science

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“…[ 50 , 51 ] Currently, there are many research targets related to TAMs, including colony stimulating factor 1, Pexidartinib, Sotuletinib, Emactuzumab, and so on. [ 52 , 53 ] Despite the increasing research on TAMs, there are still many unknowns about their role in the genesis, regulation, and treatment of HNSCC, which need to be explored by more studies. In conclusion, TAMs are an attractive target for HNSCC.…”

Section: Discussionmentioning

confidence: 99%

Macrophages in head and neck squamous cell carcinoma: A bibliometric analysis

Liang,

Wang,

et al. 2023

Medicine

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Introduction: The tumor microenvironment in head and neck squamous cell carcinoma (HNSCC) is densely infiltrated by macrophages. Utilizing bibliometric analysis, the characteristics, hotspots for research, and research frontiers related to macrophages in HNSCC were reviewed. Methods: The Web of Science Core Collection database was queried for relevant articles published from 2000 to 2022. VOSviewer and CiteSpace software were utilized to evaluate and visualize macrophage-related HNSCC research trends and hotspots. Results: Assessment of original articles revealed that the annual number of publications regarding the role of macrophages in HNSCC has increased steadily over the past 23 years. China produced the most articles, whereas the United States had the highest number of citations and highest H-index. Wuhan University and Oral Oncology were the most productive affiliation and journal, respectively. The paper published by Bray et al in the CA-A Cancer Journal for Clinicians in 2018 had the greatest number of citations. The keywords “expression,” “cancer,” and “tumor-associated macrophages (TAMs)” occurred most frequently. Conclusions: This bibliometric investigation discovered that publications about macrophages in HNSCC are steadily increasing. The majority of studies focused on macrophage polarization, macrophage markers, and inflammation in the tumor microenvironment. Furthermore, our bibliometric analysis revealed that the immunosuppressive role of tumor-associated macrophages in the tumor microenvironment and resistance to therapy in HNSCC have recently received attention.

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“…Tumor‐associated macrophages (TAMs) are one of the most abundant immune cells in TME. TAMs play a key role in tumor proliferation, migration, and angiogenesis, and can inhibit the killing effect of T cells and NK cells on tumor cells, thus promoting tumor cells to evade the immune surveillance 24 . TAMs have strong functional plasticity, which could be acquired as immunostimulatory (M1‐like) or immunosuppressive (M2‐like) abilities, and more various functional phenotypes in between of M1‐like with M2‐like 25 .…”

Section: Interactions Between Exosomes and Osccmentioning

confidence: 99%

“…TAMs play a key role in tumor proliferation, migration, and angiogenesis, and can inhibit the killing effect of T cells and NK cells on tumor cells, thus promoting tumor cells to evade the immune surveillance. 24 TAMs have strong functional plasticity, which could be acquired as immunostimulatory (M1-like) or immunosuppressive (M2-like) abilities, and more various functional phenotypes in between of M1-like with M2-like. 25 Xiao et al found that macrophages were activated to be M1-like TAMs by conditioned culture medium derived from OSCC cells, and a novel paracrine ring between cancer cells and macrophages was proposed based on OSCC-derived exosomes.…”

Section: Exosomes Mediated Immune Effects On Osccmentioning

confidence: 99%

Emerging functions and applications of exosomes in oral squamous cell carcinoma

Qie,

Sun,

Yang

et al. 2023

J Oral Pathology Medicine

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Oral squamous cell carcinoma is the most common phenotype in pathology, which accounts for 80% of all oral cancers. The therapeutic methods of oral squamous cell carcinoma include surgical excision, chemotherapy, and radiotherapy. Whereas, the high recurrence rate and poor prognosis lead to a 5‐year survival rate less than 50%. In order to explore more therapeutic strategies of oral squamous cell carcinoma, the relevant risk factors, mechanisms, and diagnostics are widely detected. The various exosome‐mediated biological effects on the development of oral squamous cell carcinoma have drawn lots of attention. Exosomes, a kind of extracellular vesicles secreted from host cells and transferred to other cells, show great potential in the regulations of tumorigenesis, progression, and metastasis on oral squamous cell carcinoma. Moreover, some studies reported that the exosomes could interact with tumor microenvironment and be applied to diagnosis or therapy of oral squamous cell carcinoma. In this work, we will summarize the frontier studies of exosomes in the tumor growth, tumor‐associated angiogenesis, invasion, and metastasis of oral squamous cell carcinoma, and then probe the current biological functions and applications of exosomes and exosome‐derived materials for the therapeutic strategies of oral squamous cell carcinoma, which would help us to update the understanding of exosomes in oral squamous cell carcinoma.

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The role of tumor-associated macrophages in oral squamous cell carcinoma

Cited by 20 publications

References 88 publications

Histologic, immunohistochemical, and <i>in situ</i> hybridization study of myxoid stroma in feline oral squamous cell carcinoma

Histologic, immunohistochemical, and <i>in situ</i> hybridization study of myxoid stroma in feline oral squamous cell carcinoma

Macrophages in head and neck squamous cell carcinoma: A bibliometric analysis

Emerging functions and applications of exosomes in oral squamous cell carcinoma

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