The prospect of eliminating malaria transmission in some regions of Brazil

Tauil, Pedro Luíz

doi:10.1590/s0074-02762011000900013

Cited by 13 publications

(20 citation statements)

References 6 publications

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“…In the Brazilian Amazon Region, the incidence of malaria is significantly influenced by political, economic, social and ecological factors (Taiul 2011). For five centuries, episodic waves of explorers, conquerors and colonists have penetrated various sections of the forest, exploiting its natural resources and native peoples, in a series of cultural successions called ‘frontiers’ (Browder et al.…”

Section: Introductionmentioning

confidence: 99%

Plasmodium vivax Duffy binding protein: baseline antibody responses and parasite polymorphisms in a well‐consolidated settlement of the Amazon Region

Kano

Sanchez

Sousa

et al. 2012

Tropical Med Int Health

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Abstractobjective To investigate risk factors associated with the acquisition of antibodies against Plasmodium vivax Duffy binding protein (PvDBP) -a leading malaria vaccine candidate -in a well-consolidated agricultural settlement of the Brazilian Amazon Region and to determine the sequence diversity of the PvDBP ligand domain (DBP II ) within the local malaria parasite population.methods Demographic, epidemiological and clinical data were collected from 541 volunteers using a structured questionnaire. Malaria parasites were detected by conventional microscopy and PCR, and blood collection was used for antibody assays and molecular characterisation of DBP II .results The frequency of malaria infection was 7% (6% for P. vivax and 1% for P. falciparum), with malaria cases clustered near mosquito breeding sites. Nearly 50% of settlers had anti-PvDBP IgG antibodies, as detected by enzyme-linked immunosorbent assay (ELISA) with subject's age being the only strong predictor of seropositivity to PvDBP. Unexpectedly, low levels of DBP II diversity were found within the local malaria parasites, suggesting the existence of low gene flow between P. vivax populations, probably due to the relative isolation of the studied settlement.conclusion The recognition of PvDBP by a significant proportion of the community, associated with low levels of DBP II diversity among local P. vivax, reinforces the variety of malaria transmission patterns in communities from frontier settlements. Such studies should provide baseline information for antimalarial vaccines now in development.

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Section: Introductionmentioning

confidence: 99%

Plasmodium vivax Duffy binding protein: baseline antibody responses and parasite polymorphisms in a well‐consolidated settlement of the Amazon Region

Kano

Sanchez

Sousa

et al. 2012

Tropical Med Int Health

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“…Historically, endemic diseases such as malaria and leishmaniosis are directly associated with demographic, environmental, socioeconomic, and cultural changes occurred in recent decades, determining a continuous reorganization of territories (Barata, 1995;Tauil, 2011).…”

Section: Discussionmentioning

confidence: 99%

Health Risk Assessment Associated With the Implementation of the Madeira Ahydroelectric Complex, Brazilian Amazon

et al. 2018

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This article analyses the health impact of the installation of the Madeira Hydroelectric Complex to the population of Porto Velho county (Amazon, Brazil) between 2001 and 2010. The incidence of a selected list of diseases was evaluated with regard to changes that took place in the human and natural environment, compared to the phase prior to the installation of the hydroelectric power projects. An assessment of environmental responsiveness and the population’s vulnerability was carried out based on a matrix of socioeconomic, health, and environmental indicators. Malaria, Aids, leishmaniosis and dengue transmission were differentially affected by the implementation of the hydroelectric power plants in a context of limited government intervention in terms of sanitation and health care infrastructure, deforestation, different forms of land use and cover, in addition to migration processes within the area influenced by the hydroelectric power plants.

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“…However, these strategies need to be emphasised in the elimination scenario (Tauil 2011). Moreover, searching for each individual case of malaria is a priority in the context of achieving zero reported cases (malERA 2011).…”

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confidence: 99%

Plasmodium vivax malaria elimination: should innovative ideas from the past be revisited?

Val

Sampaio

Cassera

et al. 2014

Mem. Inst. Oswaldo Cruz

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In the 1950s, the strategy of adding chloroquine to food salt as a prophylaxis against malaria was considered to be a successful tool. However, with the development of Plasmodium resistance in the Brazilian Amazon, this control strategy was abandoned. More than 50 years later, asexual stage resistance can be avoided by screening for antimalarial drugs that have a selective action against gametocytes, thus old prophylactic measures can be revisited. The efficacy of the old methods should be tested as complementary tools for the elimination of malaria.

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The prospect of eliminating malaria transmission in some regions of Brazil

Cited by 13 publications

References 6 publications

Plasmodium vivax Duffy binding protein: baseline antibody responses and parasite polymorphisms in a well‐consolidated settlement of the Amazon Region

Plasmodium vivax Duffy binding protein: baseline antibody responses and parasite polymorphisms in a well‐consolidated settlement of the Amazon Region

Health Risk Assessment Associated With the Implementation of the Madeira Ahydroelectric Complex, Brazilian Amazon

Plasmodium vivax malaria elimination: should innovative ideas from the past be revisited?

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