The prognostic value of the neutrophil-to-lymphocyte ratio in patients with testicular cancer

Quetglas, J.L. Bauza; Tienza, Antonio; Bertolo, Riccardo; Arroyo, X.A. Sabaté; García, J. Guimerà; Vidaña, V. Tubau; Juan, Guillem Frontera; Ayala, E. Pieras

doi:10.1016/j.purol.2020.02.002

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…Staging of the tumors, the tendency to recurrence, and CSS are worse with higher NLR [ 28 ]. Higher post-orchiectomy NLR was found independently associated with recurrence in testicular cancer patients [ 29 ]. Among advanced/metastatic bladder cancer patients, NLR could independently improve the prediction of survival outcomes.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of neutrophil-to-lymphocyte ratio (NLR) in penile cancer: A systematic review and meta-analysis

Saputra¹,

Hidayatullah²,

Kloping³

et al. 2022

Annals of Medicine &Amp; Surgery

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Section: Discussionmentioning

confidence: 99%

Prognostic value of neutrophil-to-lymphocyte ratio (NLR) in penile cancer: A systematic review and meta-analysis

Saputra¹,

Hidayatullah²,

Kloping³

et al. 2022

Annals of Medicine &Amp; Surgery

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“…21 Bauzá Quetglas ve ark., NLR'nin testis tümörü hastalarında kanser relapsını öngörmede kullanılabileceğini belirtmişlerdir. 22 Tersine, 53 orşiektomi yapılmış hastanın dâhil edildiği çalışmalarında Bolat ve ark., hastaları NLR 3,55'in altı ve üstü olarak 2 gruba ayırmışlardır. İki grup arasında progresyonsuz sağkalım ve kanser spesifik sağkalım açısından farklılık izlenmemiştir.…”

Section: Discussionunclassified

The Role of Systemic Inflammatory Markers in Predicting Post-Chemotherapy Retroperitoneal Residual Mass Pathology: Retrospective Clinical Study

Gül¹,

EKİCİ²,

ZENGİN³

et al. 2022

J Reconstr Urol

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Kemoterapi sonrası retroperitoneal lenf nodu diseksiyonu (RPLND) uygulanan metastatik seminom dışı germ hücreli testis tümörü (NSGCT) hastalarında, preoperatif inflamasyon belirteçleri (nötrofil/lenfosit oranı (NLR), platelet/lenfosit oranı (PLR)) ve görüntüleme bulgularının RPLND patolojisi ile ilişkili olup olmadığını araştırmaktır. Gereç ve Yöntemler: Kliniğimizde Ocak 2016-Şubat 2022 tarihleri arasında RPLND yapılmış hastalar geriye dönük tarandı. Preoperatif hematolojik ve biyokimyasal parametreler, bilgisayarlı tomografi (BT) bulguları, orşiektomi ve RPLND histopatoloji bulguları kaydedildi. Hastalar patolojisi canlı tümör/teratom olanlar Grup 1 ve benign (nekroz-fibroz) olanlar Grup 2 şeklinde ayrıldı. Gruplar arasında NLR, PLR, De Ritis oranı, serum tümör belirteçleri ve abdominopelvik BT'de saptanan ek büyük boyuttaki retroperitoneal lenf nodunun uzunluğu, hem orşiektomi öncesi, hem kemoterapi öncesi, hem de RPLND öncesi dönemlerde karşılaştırıldı. Bulgular: Top-lamda13 hasta çalışmaya dahil edildi (Grup 1: 10 hasta, Grup 2: 3 hasta). Gruplar arasında yaş ortalaması benzerken, orşiektomi öncesi hematolojik ve serum belirteçleri açısından fark saptanmadı (p>0,05). Kemoterapi öncesi hematolojik ve serum belirteçleri 2 grupta da benzerken, abdominopelvik BT'deki en büyük lenfadenopati (LAP) boyutları Grup 1'de anlamlı düzeyde yüksekti (p=0,03). Benzer şekilde RPLND öncesi hematolojik ve serum belirteçleri 2 grupta da benzerken, abdominopelvik BT'deki en büyük LAP boyutları Grup 1'de anlamlı düzeyde yüksekti (p=0.03). Sonuç: RPLND tümör histolojisinin preoperatif öngörüsünde basit kan testlerinin kullanımı pratik gibi gözükse de, bu tahmin için henüz tümör boyutundan başka anlamlı parametre bulunamamıştır. Anah tarKe li me ler: Nötrofil lenfosit oranı; platelet lenfosit oranı; De Ritis oranı; retroperitoneal tümörler; testis tümörleri ABS TRACT Objective: To investigate whether preoperative inflammation markers (NLR, PLR) and imaging findings are associated with retroperitoneal lymph node dissection (RPLND) pathology in patients with metastatic non-seminomatous germ cell testicular tumor (NSGCT) who underwent RPLND after chemotherapy. Material and Methods:The data of the patients who underwent RPLND in our clinic between January 2016 and February 2022 were retrospectively analyzed. Preoperative hematological and biochemical parameters, computed tomography (CT) findings, orchiectomy and RPLND histopathology findings were recorded. The patients were divided into 2 groups according to RPLND pathology: Group 1 as viable tumor/teratoma and Group 2 as benign (necrosis-fibrosis) pathology. NLR, PLR, De Ritis ratio, serum tumor markers, and the length of the additional largest retroperitoneal lymph node detected on abdominopelvic CT between the groups were compared in the pre-orchiectomy, pre-chemotherapy and pre-RPLND periods. Results: A total of 13 patients were included in the study (Group 1: 10 patients and Group 2: 3 patients). While the mean age was similar between the groups, there was no difference in terms ...

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Diagnostic and prognostic role of NLR in testicular cancer

Sarejloo,

Babadi,

Khanzadeh

et al. 2024

Exploration of Targeted Anti-Tumor Therapy

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Background: To summarize the results of available studies for investigating the role of neutrophil to lymphocyte ratio (NLR) in testicular cancer (tCa). Methods: The search was conducted on PubMed, Scopus, and Web of Science up to November 21, 2021. Finally, a total of 31 studies were included in this review. Results: NLR was higher in tCa patients compared to healthy controls and benign testis pathologies, and decreased significantly after orchiectomy. An elevated NLR predicts poor prognosis, advanced stage, presence of nodal or distant metastases, contralateral tumor development, lower time-to-cancer specific death, worse OS, and poorer response to chemotherapy. However, NLR could not differentiate between seminomas and non-seminomatous tCa. Discussion: NLR has a significant diagnostic and prognostic value in tCa.

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The prognostic value of the neutrophil-to-lymphocyte ratio in patients with testicular cancer

Cited by 3 publications

References 26 publications

Prognostic value of neutrophil-to-lymphocyte ratio (NLR) in penile cancer: A systematic review and meta-analysis

Prognostic value of neutrophil-to-lymphocyte ratio (NLR) in penile cancer: A systematic review and meta-analysis

The Role of Systemic Inflammatory Markers in Predicting Post-Chemotherapy Retroperitoneal Residual Mass Pathology: Retrospective Clinical Study

Diagnostic and prognostic role of NLR in testicular cancer

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