The prognostic value of increased leukocyte and neutrophil counts in the early phase of cerebral venous sinus thrombosis

Kamışlı, Suat; Kamışlı, Özden; Gönüllü, Sinan; Kaplan, Yüksel; Özcan, Cemal

doi:10.5505/tbdhd.2012.43531

Cited by 7 publications

(9 citation statements)

References 17 publications

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“…Various studies have reported that NLR is associated with central nervous system depression, cardiac complications, and enzyme changes seen in CO poisoning [11][12][13][14][15]. It has been also reported that the high value of NLR is associated with short-or long-term mortality in patients with acute myocardial infarction [11,12].…”

Section: Discussionmentioning

confidence: 98%

“…Depression of the central nervous system, cardiac complications, and enzyme changes may develop in CO poisoning. When these symptoms are caused by reasons other than CO poisoning, they show a relationship with neutrophil/lymphocyte ratio (NLR) [11][12][13][14][15]. Based on this relationship, we aimed at assessing the relationship between NLR at the time of presentation and the severity of clinical findings, cardiac and neurological complications.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of carbon monoxide poisonings originated from coal stove and natural gas and the evaluation of Neutrophil/Lymphocyte ratio

Günaydın¹,

Vural²,

Ok³

et al. 2015

Dicle Med J

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Bizim çalışmamızdaki amacımız ülkemizde karbonmonoksit (CO) zehirlenmesinin en sık nedeni olan kömür sobasından kaynaklanan zehirlenmeler ile doğal gaz kaçaklarının yol açtığı zehirlenmeler arasındaki epidemiyolojik, klinik, laboratuar ve prognoz farklılıklarını ortaya koymaktır. Ayrıca CO zehirlenmelerinde oluşan klinik tablonun şiddeti, prognozu, komplikasyonları ile başvuru sırasındaki nötrofil/lenfosit oranı (NLO) arasındaki ilişkiyi incelemeyi amaçladık. Yöntemler: Bu prospektif çalışmaya Ankara Eğitim ve Araştırma Hastanesi Acil Tıp Kliniği'ne 2009 Ekim-2010 Nisan tarihleri arasında başvuran akut karbonmonoksit zehirlenmesi olgularının tümü alındı. CO zehirlenmesi tanısı, anemnezinde CO zehirlenmesine neden olabilecek öykünün olması ile birlikte karboksihemoglobin (COHb) konsantrasyonunun % 10'nun üstünde olması şeklinde konuldu. Çalışmamıza toplam 100 hasta dahil edildi. Bulgular: 55 (%55) hasta kömür sobasıyla zehirlenirken, 45 (%45) hasta doğal gaz kaynaklı zehirlenmişti. Doğal gazdan zehirlenen grubun ortalama COHb düzeyi anlamlı bir şekilde daha yüksekti (p=0,01). Doğal gaz grubunun ortalama Glaskow koma skoru (GKS) değeri anlamlı bir şekilde daha düşüktü (p=0,018). Doğal gazdan zehirlenen grupta 17 hastanın HBO (hiperbarik oksijen) tedavisi ihtiyacı olurken, kömür sobasından zehirlenen grupta ise sadece 6 hastanın HBO tedavisi ihtiyacı oldu. Doğal gazdan zehirlenen grupta kömür sobasından zehirlenen gruba göre anlamlı bir şekilde HBO tedavisi ihtiyacı daha fazlaydı. (p=0,001) NLO ile COHb oranı, troponin ve GKS değerleri arasında istatistiki olarak anlamlı bir ilişki bulunmadı (Sırasıyla; p=0,872, p=0,470, p=0,896). Sonuç: Doğal gaz kaynaklı CO zehirlenmeleri kömür sobası zehirlenmelerine göre daha toksik olabilmektedir. CO zehirlenmelerinde oluşan klinik tablonun şiddeti, prognozu, komplikasyonları ile başvuru sırasındaki NLO arasında her hangi bir ilişki yoktur.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Comparison of carbon monoxide poisonings originated from coal stove and natural gas and the evaluation of Neutrophil/Lymphocyte ratio

Günaydın¹,

Vural²,

Ok³

et al. 2015

Dicle Med J

View full text Add to dashboard Cite

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“…However, known risk factors of CVT, such as infection, anticoagulant factor deficiency, and systematic autoimmune diseases, are linked with inflammatory reactions, indicating that inflammation may be involved in cerebral venous thrombogenesis ( 2 , 3 ). Clinical studies that reported the conspicuous activation of serum and cerebrospinal fluid (CSF) inflammatory biomarkers in CVT further verified inflammation’s causative role in CVT onset ( 6 – 16 ). VTE and CVT are deemed to share similar inflammatory mechanisms clinically.…”

Section: Inflammation Promotes Cerebral Venous Thrombosis Onsetmentioning

confidence: 85%

Inflammation in Cerebral Venous Thrombosis

et al. 2022

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Cerebral venous thrombosis (CVT) is a rare form of cerebrovascular disease that impairs people’s wellbeing and quality of life. Inflammation is considered to play an important role in CVT initiation and progression. Several studies have reported the important role of leukocytes, proinflammatory cytokines, and adherence molecules in the CVT-related inflammatory process. Moreover, inflammatory factors exacerbate CVT-induced brain tissue injury leading to poor prognosis. Based on clinical observations, emerging evidence shows that peripheral blood inflammatory biomarkers—especially neutrophil-to-lymphocyte ratio (NLR) and lymphocyte count—are correlated with CVT [mean difference (MD) (95%CI), 0.74 (0.11, 1.38), p = 0.02 and −0.29 (−0.51, −0.06), p = 0.01, respectively]. Moreover, increased NLR and systemic immune-inflammation index (SII) portend poor patient outcomes. Evidence accumulated since the outbreak of coronavirus disease-19 (COVID-19) indicates that COVID-19 infection and COVID-19 vaccine can induce CVT through inflammatory reactions. Given the poor understanding of the association between inflammation and CVT, many conundrums remain unsolved. Further investigations are needed to elucidate the exact relationship between inflammation and CVT in the future.

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“…The study by Artoni et al 8 , that was performed with a large group of patients with venous thrombosis, showed a lack of association between high values of PLR and NLR and an increased risk of venous thrombosis. Another study from Turkey showed a significant association between elevated NLR and CVT patients compared with healthy controls 19 . Consistent with most of the previous studies, we found higher levels of NLR and PLR levels in CVT patients compared with the healthy controls.…”

Section: Discussionmentioning

confidence: 98%

Inflammatory markers are beneficial in the early stages of cerebral venous thrombosis

Tekeşin

Tunç

2019

Arq. Neuro-Psiquiatr.

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Cerebral vein thrombosis (CVT) is a rare but serious cause of acute stroke. Inflammation is a hypothetical etiological factor in CVT. Objective: The aim of this study was to evaluate inflammatory marker levels in CVT patients and compare these with healthy individuals. Methods: This prospective case-control study was conducted with 36 newly-diagnosed CVT patients age- and sex-matched with 40 healthy individuals. The laboratory investigations included a serum hemogram, full biochemistry profiles, high sensitivity C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-HDL cholesterol ratio (MHR) values were calculated and compared between the patients and healthy participants. Results: The mean age was 41.4 ± 11.8 years for patients, and 39.3 ± 12.5 for controls. Lymphocyte, total bilirubin, indirect bilirubin, and HDL levels were significantly lower in CVT patients (p < 0.05), while CRP, and ESR values were significantly higher. In the CVT patients the mean NLR and PLR values were significantly higher than in the control individuals. Smoking rates, alcohol consumption, white blood cell, neutrophil, platelet, and MHR values were similar in both groups (p > 0.05). Conclusions: We suggest that NLR, PLR, CRP, ESR, and bilirubin can be used in clinical practice for prediction of CVT in suspected patients as they are inexpensive parameters and widely available. However, further large-scale studies are required to confirm this relationship.

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The prognostic value of increased leukocyte and neutrophil counts in the early phase of cerebral venous sinus thrombosis

Cited by 7 publications

References 17 publications

Comparison of carbon monoxide poisonings originated from coal stove and natural gas and the evaluation of Neutrophil/Lymphocyte ratio

Comparison of carbon monoxide poisonings originated from coal stove and natural gas and the evaluation of Neutrophil/Lymphocyte ratio

Inflammation in Cerebral Venous Thrombosis

Inflammatory markers are beneficial in the early stages of cerebral venous thrombosis

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