Cerebral vein thrombosis (CVT) is a rare but serious cause of acute stroke. Inflammation is a hypothetical etiological factor in CVT. Objective: The aim of this study was to evaluate inflammatory marker levels in CVT patients and compare these with healthy individuals. Methods: This prospective case-control study was conducted with 36 newly-diagnosed CVT patients age- and sex-matched with 40 healthy individuals. The laboratory investigations included a serum hemogram, full biochemistry profiles, high sensitivity C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-HDL cholesterol ratio (MHR) values were calculated and compared between the patients and healthy participants. Results: The mean age was 41.4 ± 11.8 years for patients, and 39.3 ± 12.5 for controls. Lymphocyte, total bilirubin, indirect bilirubin, and HDL levels were significantly lower in CVT patients (p < 0.05), while CRP, and ESR values were significantly higher. In the CVT patients the mean NLR and PLR values were significantly higher than in the control individuals. Smoking rates, alcohol consumption, white blood cell, neutrophil, platelet, and MHR values were similar in both groups (p > 0.05). Conclusions: We suggest that NLR, PLR, CRP, ESR, and bilirubin can be used in clinical practice for prediction of CVT in suspected patients as they are inexpensive parameters and widely available. However, further large-scale studies are required to confirm this relationship.
This study suggested that MwA may be associated with low cognitive performance which was correlated with depression and anxiety but not with WMHs. Further, longitudinal studies for assessing the relationship between WMHs, cognitive functions, and migraine, and for establishing the causality are warranted.
Aim: The aim of this study was to evaluate erythrocyte sedimentation rate (ESR), high sensitivity C-reactive protein (hsCRP), neutrophil-to-lymphocyte ratio (NLR), monocyte to HDL-C ratio (MHR), and bilirubin levels in patients with migraine and compare with levels measured in healthy subjects. Methods: This retrospective case-control study included 136 migraine patients and 80 healthy controls who were admitted to our neurology outpatient clinic or emergency between June 2017 and June 2018. Laboratory examinations, disease characteristics, presence of aura, and the presence of white matter hyperintensities (WMHs) were recorded and demographic features and laboratory data were compared between two groups. Results: The mean age of the case group was 36.9 ± 10.6 years and the control group was 37 ± 12 years. In the patient group, total bilirubin, direct bilirubin, indirect bilirubin, and lymphocyte values were significantly lower than the control group. NLR, hsCRP, and ESR levels were significantly higher in the patient group than the control group. The patient and control groups did not show a significant difference according to the presence of WMHs. In the group with aura, monocyte and MHR values were higher than those without aura. The hsCRP values in the group with aura were significantly lower than the group without aura. Conclusion: This study showed that low bilirubin and high NLR, MHR, hsCRP, and ESR values might be potential inflammatory markers in migraine patients. These markers may contribute to our understanding of the pathophysiology of migraine. Since the cost of these tests is cheap and they are widely used, it is possible to believe that they may be useful for protecting migraine patients against long-term comorbidities.Amaç: Bu çalışmanın amacı migren hastalarında eritrosit sedimentasyon hızı (ESR), yüksek duyarlılıklı Creaktif protein (hsCRP), nötrofil-lenfosit oranı (NLO), monosit-HDL-C oranı (MHO) ve bilirubin düzeylerinin değerlendirilmesi ve sağlıklı bireylerde ölçülen seviyelerle karşılaştırılmasıdır. Yöntemler: Bu retrospektif vaka-kontrol çalışmasına Haziran 2017-Haziran 2018 tarihleri arasında hastanemiz nöroloji polikliniğine veya acil servisine başvuran 136 migren hastası ve 80 sağlıklı kontrol dahil edildi. Tüm katılımcıların laboratuvar tetkikleri, hastalık özellikleri, aura varlığı ve beyaz cevher lezyonlarının varlığı kaydedildi ve demografik özellikler ve laboratuvar verileri iki grup arasında karşılaştırıldı. Bulgular: Vaka grubunun yaş ortalaması 36.9 ±10.6 yıl ve kontrol grubunun 37±12 yıl idi. Hasta ve kontrol grupları arasında yaş ve cinsiyet açısından anlamlı fark saptanmadı. Vaka grubunda total bilirubin, direkt bilirubin, indirekt bilirubin, lenfosit değerleri kontrol grubuna göre anlamlı derecede düşüktü. Hasta grubunda NLO, hsCRP, ESR düzeyleri kontrol grubuna göre anlamlı yüksekti. Vaka ve kontrol grupları beyaz cevher lezyonları varlığı açısından anlamlı farklılık göstermedi. Aurası olan ve olmayan migren hastalarında yaş, cinsiyet, total bilirubin, direkt bilirubin ve ...
The aim of this study was to investigate retinal nerve fiber layer (RNFL), ganglion cell layer (GCL) thickness, macular changes (central subfield thickness (CST), cube average thickness (CAT), cube volume (CV) in patients with migraine using spectral-domain optical coherence tomography (OCT) and to assess if there was any correlation with white matter lesions (WML). In this prospective case-control study, RNFL, GCL thickness and macular changes of 19 migraine patients with aura (MA), 41 migraine without aura (MO) and 60 age- and gender-matched healthy subjects were measured using OCT device. OCT measurements were taken at the same time of the day to minimize the effects of diurnal variation. The average, inferior and superior quadrant RNFL thickness were significantly thinner in patients with migraine (p = 0.017, p = 0.010, p = 0.048). There was also a significant difference between patients with and without aura in the mean and superior quadrant RNFL thickness (p = 0.02, p = 0.043).While there was a significant thinning in CST and CAT in patients with migraine (p = 0.020), there were no significant difference in GCL measurements (p = 0.184). When the groups were compared to the control group, there were significant differences between MA and the control group regarding average, superior and inferior quadrant RNLF thickness (p < 0.001, p = 0.025, p < 0.001). On the other hand, there were significant differences between MO and the control group regarding average and inferior faces (p = 0.037, p = 0.04). When OCT measurements were evaluated according to the frequency of attacks, CST and GCL thickness were significantly thinner in patients who had more than four attacks a month (p = 0.024, p = 0.014). In patients with WML, only CV measurements were significantly thinner than migraine patients without WML (p = 0.014). The decreased RNFL, CST, CAT and CV of the migraine patients might be related to the vascular pathology of the disease. Because WML was not correlated with the same measurements except CV, we think that further studies are needed to evaluate the etiopathologic relationship between OCT measurements and WML in migraine patients.
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