The Prognostic and Predictive Value of microRNAs in Patients with H. pylori-positive Gastric Cancer

Parizadeh, Seyed Mostafa; Avan, Amir; Ghandehari, Maryam; Goldani, Fatemeh

doi:10.2174/1381612825666190110144254

Cited by 8 publications

(3 citation statements)

References 37 publications

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“…H. pylori is the primary human pathogen in the gastric mucosa of almost half of the global population, which participates in developing GC through the regulation of miRNA expression. miRNAs have been noticed as prognostic biomarkers in GC due to their gene regulatory role in cells, such as tumor suppressors and promoter functions [ 86 ].…”

Section: Discussionmentioning

confidence: 99%

Prognostic biomarkers and molecular pathways mediating Helicobacter pylori–induced gastric cancer: a network-biology approach

2023

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Cancer of the stomach is the second most frequent cancer-related death worldwide. The survival rate of patients with gastric cancer (GC) remains fragile. There is a requirement to discover biomarkers for prognosis approaches. Helicobacter pylori in the stomach is closely associated with the progression of GC. We identified the genes associated with poor/favorable prognosis in H. pylori–induced GC. Multivariate statistical analysis was applied on the Gene Expression Omnibus (GEO) dataset GSE54397 to identify differentially expressed miRNAs (DEMs) in gastric tissues with H. pylori–induced cancer compared with the H. pylori–positive with non-cancerous tissue. A protein interaction map (PIM) was built and subjected to DEMs targets. The enriched pathways and biological processes within the PIM were identified based on substantial clusters. Thereafter, the most critical genes in the PIM were illustrated, and their prognostic impact in GC was investigated. Considering p-value less than 0.01 and |Log2 fold change| as >1, five microRNAs demonstrated significant changes among the two groups. Gene functional analysis revealed that the ubiquitination system, neddylation pathway, and ciliary process are primarily involved in H. pylori–induced GC. Survival analysis illustrated that the overexpression of DOCK4, GNAS, CTGF, TGF-b1, ESR1, SELE, TIMP3, SMARCE1, and TXNIP was associated with poor prognosis, while increased MRPS5 expression was related to a favorable prognosis in GC patients. DOCK4, GNAS, CTGF, TGF-b1, ESR1, SELE, TIMP3, SMARCE1, TXNIP, and MRPS5 may be considered prognostic biomarkers for H. pylori–induced GC. However, experimental validation is necessary in the future.

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Section: Discussionmentioning

confidence: 99%

Prognostic biomarkers and molecular pathways mediating Helicobacter pylori–induced gastric cancer: a network-biology approach

2023

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“…Aberrant regulation of miRNAs can function as oncogenes or anti-oncogenes by binding with its specific target mRNAs, resulting in mRNA degradation or/and translational repression (9). Studies have revealed the regulatory roles of miRNAs in H. pylori-induced inflammation and carcinogenesis (10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Downregulation of miR‑7 and miR‑153 is involved in Helicobacter pylori CagA induced gastric carcinogenesis and progression

Song,

Guo,

Liu

et al. 2023

Int J Oncol

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Helicobacter pylori (H. pylori) infection plays a pivotal role in the development of gastric cancer (GC). However, the association between aberrant microRNAs (miRNAs/miRs) expression and H. pylori-induced GC remains poorly understood. The present study reported that repeated infection of H. pylori caused the oncogenicity of GES-1 cells in BALB/c Nude mice. miRNA sequencing revealed that both miR-7 and miR-153 were significantly decreased in the cytotoxin-associated gene A (CagA) positive GC tissues and this was further confirmed in a chronic infection model of GES-1/HP cells. Further biological function experiments and in vivo experiments validated that miR-7 and miR-153 can promote apoptosis and autophagy, inhibit proliferation and inflammatory response in GES-1/HP cells. All the associations between miR-7/miR-153 and their potential targets were revealed via bioinformatics prediction and dual-luciferase reporter assay. Particularly, downregulation of both miR-7 and miR-153 obtained an improved sensitivity and specificity in diagnosing H. pylori (CagA+)-induced GC. The present study identified that the combination of miR-7 and miR-153 may be regarded as novel therapeutic targets in H. pylori CagA (+)-associated GC.

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“…MiRNAs are involved in a variety of cellular processes, from embryonic development and immunity to carcinogenesis, by interacting with their multiple targets [4]. MiRNAs also play a vital role in the pathogenesis of gastric cancer [5,6]. MicroRNA-155 (miR-155) is a multifunctional miRNA that is involved in many disease processes including hematopoietic development [7,8], inflammatory responses [9,10], autoimmune [11], and tumorigenesis [12,13].…”

Section: Introductionmentioning

confidence: 99%

Analysis of the relationship between MIR155HG variants and gastric Cancer susceptibility

Zou

et al. 2020

BMC Gastroenterol

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Background: Gastric cancer is one of the most common cancers in the world and a major cause of cancer-related death. This study aims to determine whether genetic variations in MIR155HG could be associated with gastric cancer risk. Materials & methods: A total of 506 gastric cancer patients and 500 healthy controls were enrolled in this study. Genotypes were examined with the MassARRAY platform and data management and analysis were conducted with the Typer Software. Odds ratios (OR) and 95% confidence intervals (CIs) were calculated with logistic regression adjusting for age and gender to evaluate the associations between SNPs with gastric cancer in genetic model analysis. Results: The "CC" genotype of rs4143370 decreased the risk of gastric cancer in genotype model (p = 0.020) and recessive model (p = 0.018). Inversely, the "CC" genotype of rs1893650 increased the risk of gastric cancer in genotype model (p = 0.023) and recessive model (p = 0.014). Stratified analysis showed that rs11911469 was associated with an increased risk of gastric cancer only among the male group in the dominant model (p = 0.039) and additive model (p = 0.030). The haplotype analysis showed a strong linkage disequilibrium among these six SNPs (rs4143370, rs77699734, rs11911469, rs1893650, rs34904192 and rs928883). Conclusion: This study confirmed the relationship between SNPs of MIR155HG and the gastric cancer risk among the Chinese Han population. Our data may provide a new perspective to understand the aetiology of gastric cancer.

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The Prognostic and Predictive Value of microRNAs in Patients with H. pylori-positive Gastric Cancer

Cited by 8 publications

References 37 publications

Prognostic biomarkers and molecular pathways mediating Helicobacter pylori–induced gastric cancer: a network-biology approach

Prognostic biomarkers and molecular pathways mediating Helicobacter pylori–induced gastric cancer: a network-biology approach

Downregulation of miR‑7 and miR‑153 is involved in Helicobacter pylori CagA induced gastric carcinogenesis and progression

Analysis of the relationship between MIR155HG variants and gastric Cancer susceptibility

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