The problem of data starvation in the peri- and postperinatal period

Волобуев, А. Н.; Давыдкин, И. Л.; Pyatin, V. F.; Romanchuk, N.

doi:10.29296/25877305-2018-08-08

Cited by 18 publications

(6 citation statements)

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“…Рисунок 13. Стабильность иммунитета зависит от здоровой микробиоты кишечника [1] Когнитивное снижение является отличительной чертой старения нервной системы, характеризуется увеличением потери памяти и ухудшением умственных способностей, что в свою очередь создает благоприятный фон для развития нейродегенеративных заболеваний [4,12,13].…”

Section: рисунок 5 последствия дисрегуляции иммунного ответаunclassified

“…Скорее, функциональный или физиологический возраст, определяемый биомаркерами (т. е., биологический возраст), обеспечивает лучшую оценку траектории успешного или патологического старения. Микрочип и технология секвенирования следующего поколения позволяет исследовать экспрессию тысяч генов, которые могут быть использованы в качестве биомаркеров физиологического и/(или) функционального возраста и указать на механизмы, лежащие в основе изменчивости старения [2,12,13,28,29].…”

Section: рисунок 5 последствия дисрегуляции иммунного ответаunclassified

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Age and Microbiota: Epigenetic and Dietary Protection, Endothelial and Vascular Rehabilitation, the New Operated Healthy Biomicrobiota

Romanchuk

2020

BSP

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The main modern tools and techniques of epigenetic, dietary and biomicrobiotic protection of healthy ageing have been studied. Artificial intelligence, brain-microbiota neural networks allow to control interaction of genetic and epigenetic programs of ageing and healthy longevity. The new managed healthy biomicrobiota and personalized functional and balanced nutrition of ‘brain and microbiota’ is a long-term medical program of the patient, which allows the combined application of nutritional epigenetics and pharmacepigenetics, and the main thing to carry out prevention of polypragmasia. Multimodal tools, biochyping, neural and brain chips, next-generation (new) sequencing technologies create biomarkers to manage the structure of healthy biomicrobiota and functional nutrition, depending on the targets achieved. A functional food product using biomarkers and artificial intelligence technologies is a target breeding ground for both the body in general and biomicrobiota in particular. Chronomedical technologies are mathematical models and artificial intelligence that predict human biological age using DNA methylation data, histone modifications, nucleosome remodeling, and microRNA, and are the most accurate biomarkers of the aging process. Epigenetic mechanisms (DNA methylation, histone modifications, ncRNAs) are interconnected and form an ‘epigenetic network’. Lifestyle factors and environmental exposures leave epigenetic marks on our DNA that impact gene expression; some have protective effects while others are harmful. Genetic and epigenetic factors that ensure longevity and super-longevity require a reasonable new human interaction with nature and society, and responsibility for future healthy generations.

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Section: рисунок 5 последствия дисрегуляции иммунного ответаunclassified

Age and Microbiota: Epigenetic and Dietary Protection, Endothelial and Vascular Rehabilitation, the New Operated Healthy Biomicrobiota

Romanchuk

2020

BSP

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“…Нейроваскулярные связи нарушаются в определенных неврологических условиях. Необходимо, установить как сердечно-сосудистые заболевания могут повлиять на регуляцию CBF и нейроваскулярные связи [1][2][3][4][5][6][7].…”

Section: биофизика и нейрофизиология сосудистой деменции и болезни алunclassified

“…Нами, экспериментально и 25-летними наблюдениями было показано, что длительно существующее состояние гипоперфузии приводит к гиппокампальным нарушениям. Этот процесс сопровождается нарушениями памяти, структурным изменением капилляров в области гиппокампа, нарушением обмена глюкозы и белков, отложением βамилоида, активацией глиальной ткани, гибелью нейронов гиппокампа [1][2][3][4][5][6][7][14][15][16].…”

Section: клинико-биофизические принципы лечения сосудистой деменции иunclassified

“…Развивается сенильная сосудистая деменция. При раннем обнаружении начавшихся патологических процессов, необходимо проведение лечебных мероприятий, направленных на восстановление церебрального кровотока или, по крайней мере, замедление патологических процессов [1][2][3][4][5][6][7].…”

Section: клинико-биофизические принципы лечения сосудистой деменции иunclassified

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Clinical and Biophysical Principles of Vascular Dementia and Alzheimer’s Disease Treatment

Bulgakova

Romanchuk

Волобуев

2019

BSP

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Biophysics of blood circulation in Alzheimer’s disease is characterized by disorders of laminar blood flow and cerebral hypoperfusion. As a result, failure intracellular metabolism, there is a cascade of changes in neurons associated with the processes of excitotoxicity and oxidant stress, which in turn stimulates amyloidogenesis. Experimental and 25-year observations have shown that the long-existing state of hypoperfusion leads to hippocampal disorders. This process is accompanied by memory impairment, structural changes in the capillaries in the hippocampus, impaired glucose and protein metabolism, β–amyloid deposition, activation of glial tissue, death of hippocampal neurons. Neuroreflex disruption in the ‘cerebral heart’ and a violation of cerebrovascular homeostasis contributes to the development of vascular dementia through the following mechanisms, including cerebral microangiopathy, endothelial dysfunction, oxidative stress, neuronal damage, the increase in β–amyloid neurotoxicity, apoptosis, etc. The duration of therapy with antiglutamatergic and multimodal drugs in Alzheimer’s disease requires constant multidisciplinary monitoring of targets and medical and social control in the system of long-term care. Lifelong acquisition of knowledge, information positive Nano communication enable the preservation of mental health and active longevity. Innovative methods of P4-medicine of neuroplasticity management allow to carry out timely prevention of the factors reducing neuroplasticity, to keep factors of positive influence on visceral and cognitive brain, and the main thing — in due time to apply in practical health care the combined methods of preservation and development of the human cognitive brain.

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Science of Cognitive Brain and Quantum Biophysics Homo sapiens 21st Century: hybrid Neuroimaging and Nuclear medicine, 5P Medicine and 5G Technology, Neurobiology and Neurophysiology of Quantum Brains, Psychoanalysis, Art-Medicine, Bioelementology and Nutriciology

Volobuev,

Romanchuk,

Romanchuk

et al. 2024

Bulletin of Science and Practice

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New discoveries in the field of genetics and epigenetics, the scientific union of neurobiology and neurophysiology of the quantum brain Homo sapiens of the 21st century, the achievements of biophysics, hybrid neuroimaging and nuclear medicine, the introduction of nutritionology and bioelementology technologies, the 5P of Medicine and 5G Technology, the replication of compliance of art medicine and modern psychoanalysis made it possible to manage 21st century Human cognitive brain. Scientific progress and 33 years of experimental experience of biophysics in the field of neurogeriatrics and neurocardiology, neuroendocrinology and psychoneuroimmunology made it possible to argue that “nerve cells are restored”, the quantum human brain is Controlled, high-quality and healthy longevity Homo sapiens of the 21st century is achievable. Humankind needs to know (discover, prove) in the near future the existence of more than 450 trillion neurosynaptic and neurocosmic interactions between the cognitive mind and the universe.

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The problem of data starvation in the peri- and postperinatal period

Cited by 18 publications

References 1 publication

Age and Microbiota: Epigenetic and Dietary Protection, Endothelial and Vascular Rehabilitation, the New Operated Healthy Biomicrobiota

Age and Microbiota: Epigenetic and Dietary Protection, Endothelial and Vascular Rehabilitation, the New Operated Healthy Biomicrobiota

Clinical and Biophysical Principles of Vascular Dementia and Alzheimer’s Disease Treatment

Science of Cognitive Brain and Quantum Biophysics Homo sapiens 21st Century: hybrid Neuroimaging and Nuclear medicine, 5P Medicine and 5G Technology, Neurobiology and Neurophysiology of Quantum Brains, Psychoanalysis, Art-Medicine, Bioelementology and Nutriciology

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