The problem «lead and health of workers» in the conditions of modern industry

Кузьмина, Л.П.; Sorkina, N S; Хотулева, А.Г.; Bezrukavnikova, L. M.; Артемова, Л. В.

doi:10.31089/1026-9428-2018-4-14-19

Cited by 5 publications

(1 citation statement)

References 1 publication

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“…Например, показано, что лица с полиморфизмом гена дегидратазы δ-аминолевулиновой кисло-ты оказываются более восприимчивыми к неблагоприятному воздействию свинца [10]. Учитывая взаимосвязь обмена свинца и железа, наличие полиморфизма гена HFE-белка, ассоциированного с гемохроматозом, может модифицировать абсорбцию не только железа, но и свинца [22], показана значимость выявления этого генетического полиморфизма для оценки чувствительности организма к воздействию свинца [6].…”

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The problem «lead and health of workers» in the conditions of modern industry

Кузьмина¹,

Sorkina²,

Хотулева³

et al. 2018

Myditsina truda I promyshlennaya ekologiy

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В статье охарактеризовано современное состояние проблемы воздействия свинца на здоровье работающих, указаны перспективные направления дальнейших исследований. На основе данных углубленного обследования работников свинецперерабатывающего предприятия доказана стадийность адаптации организма работника к воздействию свинца, обоснована необходимость установления новых допустимых значений биомаркеров воздействия свинца на организм работающих в контакте со свинцом. Доказана значимость в комплексе профилактических мероприятий правильного использования средств индивидуальной защиты, мер личной гигиены, а также эффективность применения пектина в лечебно-профилактическом питании. Учитывая комбинированное воздействие свинца на организм работающих современных предприятий, показана важность оценки микроэлементного гомеостаза. Подтверждена значимость расширения спектра определяемых биомаркеров эффекта при проведении биологического мониторинга и для оценки генетически обусловленной чувствительности к воздействию свинца.

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The problem «lead and health of workers» in the conditions of modern industry

Кузьмина¹,

Sorkina²,

Хотулева³

et al. 2018

Myditsina truda I promyshlennaya ekologiy

Self Cite

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Erythrocyte and reticulocyte parameters during biological monitoring of lead exposure to the body

Хотулева

Kozyreva

2020

Med. tr. prom. èkol.

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Introduction. The most susceptible to lead is the hematopoietic system of hematopoietic organs due to lead inhibition of heme and globin synthesis and cytotoxic effect on the membrane of Mature red blood cells. The aim of study was to evaluate the informative value of the study of erythrocyte and reticulocyte parameters determined on modern hematological analyzers in patients working in contact with lead during medical and biological monitoring. Materials and methods. 45 employees of the lead battery processing plant and 30 persons of control group were examined. The level of lead in the blood was determined by atomic absorption spectrometry, δ-ALA in the urine-by the reaction of pyrol formation with acetylacetone in terms of gram of creatinine, the study of hematological parameters was performed on a Sysmex HT-2000i analyzer. Statistical processing of the results was performed using the program STATISTICA 10.0. Results. Significant changes in erythrocytic (RDW) and reticulocytic (RET, IRF, LFR, MFR, HFR, RET-He) parameters, erythropoietin in workers in contact with lead compared to the control group, changes in MCV, MCH, RDW, RET indicators in the group working in dynamics after 2 years were revealed. Associations of hematological parameters with biomarkers of exposure and effect (lead level in blood and ALA in urine) were revealed. Conclusions. Assessment of erythrocyte (MCV, MCH, RDW) and reticulocyte parameters (RET% and their distribution by maturity) in dynamics during periodic medical examinations of workers in contact with lead allows us to detect the development of hematological disorders at early stages.

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Cardiovascular Toxicity in Copper Production Workers Exposed to Heavy Metals

Будкарь

Gurvich

Карпова

et al. 2020

HAS

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Introduction. Cardiovascular diseases (CVD) are a leading cause of morbidity and mortality. The role of occupational hazards in the CVD prevalence remains to be clarified. Material and methods. Here we report the results of the study of risk factors and CVD prevalence in 590 workers at the largest copper production plants in the Sverdlovsk region, exposed to heavy metals in the workplace. The workers` health information was obtained during a regular medical examination in 2018. The lead concentration increase to 1.3-1.8 occupational exposure limits was registered in the working areas of the concentrating mill (for bunkerman) and copper smelting workshops (transporter, smelter, converter, non-ferrous metal spreader, repairman, electrician). Results. We studied the exposure indices (Pb level in blood), the response markers (reticulocyte count, erythrocytes basophilic stippling, coproporphyrin, and aminolevulinic acid in the urine), and their correlation to a working tenure. Based on this analysis, we attributed CVD risk factors and cardiovascular diseases to the occupation, in order to potentially modify some of those risk factors and ultimately inform the risk management. Hypertension occurred in 57% of the examined workers, which is higher than in the general population. We calculated relative risk, confidence intervals and attributable fraction. We developed a predictive mathematical model (stepwise logistic regression) to predict high-stage hypertension and identified the risk factors associated with its development. Conclusions. Correlation analysis revealed direct correlations between stages 2 and 3 hypertension and a working tenure over 20 years. We think it’s reasonable to consider the documented CVDs as related to the toxic effects of heavy metals (lead and cadmium).

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The problem «lead and health of workers» in the conditions of modern industry

Cited by 5 publications

References 1 publication

The problem «lead and health of workers» in the conditions of modern industry

The problem «lead and health of workers» in the conditions of modern industry

Erythrocyte and reticulocyte parameters during biological monitoring of lead exposure to the body

Cardiovascular Toxicity in Copper Production Workers Exposed to Heavy Metals

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