The PRIAMO study: age- and sex-related relationship between prodromal constipation and disease phenotype in early Parkinson’s disease

Picillo, Marina; Palladino, Raffaele; Erro, Roberto; Alfano, Rossella; Colosimo, Carlo; Marconi, Roberto; Antonini, Angelo; Barone, Paolo; Morgante, Francesca; Benincasa, Dario; Quatrale, R.; Biguzzi, Sara; Braga, Massimiliano; Ceravolo, Maria Gabriella; Capecci, Marianna; Meco, Giuseppe; Caravona, N.; Scala, R; Falco, Fabrizio Antonio de; Pezzoli, Gianni; Gaspari, Danilo De; Bottacchi, E.; Giovanni, Mario Di; Cannas, Antonino; Floris, Gianluca; Gallerini, Simone; Grasso, Lucia; Gaglio, Rosa Maria; Gurgone, G; Volpe, Giovanni; Zappulla, Salvatore; Ceravolo, Roberto; Kiferle, Lorenzo; Ramat, Silvia; Meoni, Sara; Pisani, Antonio; Moschella, Vincenzo; Morgante, Francesca; Savica, Rodolfo; Pepe, Fulvio; Ciccarelli, Gian Paolo; Petretta, V.; Giglia, Rosa M.; Randisi, Maria Giovanna; Iemolo, Francesco; Avarello, Tania P.; Romeno, M.; Santangelo, Gabriella; Stocchi, Fabrizio; Sciortino, Giuseppa; Sorbello, Veronica; Nicoletti, Alessandra; Tiple, Dorina; Fabbrini, Giovanni; Bentivoglio, Anna Rita; Pontieri, Francesco E.; Guidubaldi, Arianna; Muoio, R.; Toni, Vincenzo; Dotto, Paolo Del; Logi, Chiara; Ciacci, G.; Ulivelli, Monica; Perini, Michele; Lanfranchi, Silvia; Griffini, Samantha; Troianiello, Biagio; Baratti, M; Amidei, S.; Consoli, Domenico; Iellamo, M.; Cuomo, Teresa; Scaglioni, Augusto; Medici, D.; Manfredi, M.; Abbruzzese, Giovanni; Brigida, G. Di; Cocco, Ga; Agnetti, Virgilio; Cossu, Giovanni; Deriu, Marcello; Abrignani, M.; Modica, Chiara; Albani, G; Milan, Elisa; Martinelli, Paolo; Scaglione, Cesa; Mucchiut, M.; Zanini, Sergio; Pennisi, F.; Soliveri, Paola; Albanese, Alberto; Massimo, P.; Bartolomei, Luigi; Capus, L.; Ferigo, Laura; Marano, Riccardo; Nastasi, Valentina; Luciano, Rosa; Maiello, Luigi; Simone, P.; Fogli, Danilo; Lopiano, Leonardo; Pesare, M.; Nordera, Giampietro; Pilleri, E.; Scaravilli, Tomaso; Giaccaglini, E.; Alesi, C; Petrone, Alfredo; Trianni, Giorgio

doi:10.1007/s00415-020-10156-3

Cited by 17 publications

(16 citation statements)

References 20 publications

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“…In clinical screenings or research settings, in which the ability of a psychometric scale to identify high-risk cases for a more comprehensive/objective assessment or study stratification is important, a cutoff score with high sensitivity is preferable, typically at a cost of lower specificity. Using the GIDS-PD Constipation subscore cutoff, 46.8% of PD cases had constipation, supporting previous prevalence studies such as Chaudhuri et al 1 with a prevalence of 46.7% and Picillo et al 65 with 46.5% in similarly sized samples. Both studies used similar definitions of constipation, whereas other prevalence studies used 2 or even 1 bowel movement per week to stratify constipated versus nonconstipated patients and thus reported lower prevalence.…”

Section: T H E G a S T R O I N T E S T I N A L D Y S F U N C T I O N S C A L E F O R P A R K I N S O N ' S D I S E A S Esupporting

confidence: 81%

The Gastrointestinal Dysfunction Scale for Parkinson's Disease

2021

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A BS TRACT: Background: Gastrointestinal dysfunction is an important feature of Parkinson's disease (PD), and there is increasing evidence that it may play a key role in the disease process. However, its assessment is limited by different tools and underlying differences in diagnostic criteria for gastrointestinal dysfunction. To date, there is no psychometric instrument for quantitative evaluation of gastrointestinal symptoms specifically designed for use in PD. Objective: The objective of this study was to develop a self-report questionnaire-based instrument, the Gastrointestinal Dysfunction Scale for Parkinson's Disease, and to evaluate its psychometric properties. Methods: We performed a literature review and conducted 3 focus groups to develop the Gastrointestinal Dysfunction Scale for Parkinson's Disease. Three hundred and sixteen patients with PD and 55 controls completed the Gastrointestinal Dysfunction Scale for Parkinson's Disease, the Non-Motor Symptom Scale, the Hospital Anxiety and Depression Scale, and a stool diary adapted from the Bristol Stool Chart. Results: The Gastrointestinal Dysfunction Scale forParkinson's Disease demonstrated good internal consistency (Cronbach's α = 0.82) and test-retest stability (0.79 < ICCs > 0.94). Correlation analyses supported good convergent and divergent validity. Receiver operating characteristic analysis demonstrated that a cutoff score of ≥9 on the Gastrointestinal Dysfunction Scale for Parkinson's Disease Constipation subscale discriminates between PD patients with and without constipation. Conclusions: The Gastrointestinal Dysfunction Scale for Parkinson's Disease is a novel disease-specific selfreport tool to quantitatively assess the presence and severity of gastrointestinal dysfunction features in patients with PD, with strong reliability and validity. Further longitudinal studies are needed to demonstrate its utility in tracking gastrointestinal dysfunction in PD clinical cohorts.

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Section: T H E G a S T R O I N T E S T I N A L D Y S F U N C T I O N S C A L E F O R P A R K I N S O N ' S D I S E A S Esupporting

confidence: 81%

The Gastrointestinal Dysfunction Scale for Parkinson's Disease

2021

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“…Our group previously demonstrated the presence of constipation was a risk factor for future cognitive decline among participants newly diagnosed with PD who were followed for five years [4] . Findings from the PRIAMO study, revealed that prodromal constipation was predictive of subjective reports of cognitive complaints and apathy among 385 PD patients who were followed for two years [5] . Unlike the current study, the Picillo et al study did not find a significant association between prodromal constipation and depression.…”

Section: Discussionmentioning

confidence: 99%

“…It is hypothesized that disruption of the gut-environment contributes to the progression of a variety of motor and non-motor symptoms [3] . Indeed, GI symptoms have been shown to be predictive of cognitive impairment and decreased motivation among individuals newly diagnosed with PD [4] , [5] .…”

Section: Introductionmentioning

confidence: 99%

“…Although a potential association between the GI environment and psychiatric symptoms has been proposed, vis-à-vis the gut-brain axis [2] , [20] , this topic has received minimal investigation among individuals with PD [5] . The current study sought to investigate the longitudinal and directional associations between depression, anxiety and GI symptoms.…”

Section: Introductionmentioning

confidence: 99%

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A bidirectional relationship between anxiety, depression and gastrointestinal symptoms in Parkinson’s disease

Jones

Dominguez

Bunch

et al. 2021

Clinical Parkinsonism & Related Disorders

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“…constipation[29][30][31]. In our study sample, women were more susceptible than men to worsening of the mental aspects of QOL with regard to anxiety and stress during the COVID-19 pandemic.…”

mentioning

confidence: 65%

Impact of the COVID-19 Pandemic on the Quality of Life of Patients with Parkinson’s Disease and Their Caregivers: A Single-Center Survey in Tochigi Prefecture

Suzuki

Numao

Komagamine

et al. 2021

JPD

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Background: The coronavirus disease 2019 (COVID-19) pandemic has negatively affected the mental health of the general population. Objective: We investigated the determinants of quality of life (QOL) in Parkinson’s disease (PD) patients during the COVID-19 pandemic. Methods: Impacts of lifestyle changes due to the COVID-19 pandemic on 100 patients with PD and their caregivers/spouses were assessed. The Hospital Anxiety and Depression Scale was used to assess anxiety and depression. The physical component summary (PCS) and mental component summary (MCS) scores of the short form (SF)-8 were used to evaluate health-related QOL. Results: Regarding health-related QOL, physical function, role physical, general health, vitality and the PCS score were significantly worse in PD patients than in caregivers. Worsening of PD-related symptoms, increased stress, and decreased physical activity were observed in 29.0%, 37.0% and 44.0% of PD patients, respectively. Sixteen patients (16.0%) experienced problems with hospital access, but none reported medication shortages. Strong concerns about COVID-19 were reported by 47.0% of caregivers and 50.0% of PD patients. In PD patients, increased gait disturbance and rigidity, disease severity, smoking, the levodopa equivalent dose and decreased body weight predicted a worse PCS score; anxiety, depression, female sex, stress and long disease duration predicted a worse MCS score. In caregivers, age and smoking contributed to a worse PCS score; depression, stress and worsening patient mood contributed to a worse MCS score. Conclusion: We report the negative impacts of the COVID-19 pandemic on health-related QOL and its determinants in PD patients and their caregivers.

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The PRIAMO study: age- and sex-related relationship between prodromal constipation and disease phenotype in early Parkinson’s disease

Cited by 17 publications

References 20 publications

The Gastrointestinal Dysfunction Scale for Parkinson's Disease

The Gastrointestinal Dysfunction Scale for Parkinson's Disease

A bidirectional relationship between anxiety, depression and gastrointestinal symptoms in Parkinson’s disease

Impact of the COVID-19 Pandemic on the Quality of Life of Patients with Parkinson’s Disease and Their Caregivers: A Single-Center Survey in Tochigi Prefecture

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