The Gastrointestinal Dysfunction Scale for Parkinson's Disease

Camacho, Marta; Greenland, Julia C.; Williams‐Gray, Caroline H.

doi:10.1002/mds.28675

Cited by 14 publications

(11 citation statements)

References 65 publications

(133 reference statements)

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“…In contrast, the SCOPA-AUT ( 16 ) obtains more detailed information about the whole GIT and autonomic symptoms. In addition, there is the GIDS-PD, which has also been newly developed and validated in PD to assess gastrointestinal dysfunction including the entire GIT ( 36 ). However, there is no questionnaire, which focuses on the lower GIT and covers symptoms of dysmotility and constipation.…”

Section: Discussionmentioning

confidence: 99%

The Gut Dysmotility Questionnaire for Parkinson's disease: Insights into development and pretest studies

et al. 2023

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ObjectiveA total of 48% of patients with Parkinson's disease (PD) present symptoms of gastrointestinal dysfunction, particularly constipation. Furthermore, gastrointestinal tract (GIT)-related non-motor symptoms (NMSs) appear at all stages of PD, can be prodromal by many years and have a relevant impact on the quality of life. There is a lack of GIT-focused validated tools specific to PD to assess their occurrence, progress, and response to treatment. The aim of this study was to develop and evaluate a novel, disease- and symptom-specific, self-completed questionnaire, titled Gut Dysmotility Questionnaire (GDQ), for screening and monitoring gastrointestinal dysmotility of the lower GIT in patients with PD.MethodsIn phase 1, a systematic literature review and multidisciplinary expert discussions were conducted. In phase 2, cognitive pretest studies comprising standard pretests, interviews, and evaluation questionnaires were performed in patients with PD (n = 21), age- and sex-matched healthy controls (HC) (n = 30), and neurologists (n = 11). Incorporating these results, a second round of cognitive pretests was performed investigating further patients with PD (n = 10), age- and sex-matched HC (n = 10), and neurologists (n = 5). The questionnaire was adapted resulting in the final GDQ, which underwent cross-cultural adaptation to the English language.ResultsWe report significantly higher GDQ total scores and higher scores in five out of eight domains indicating a higher prevalence of gastrointestinal dysmotility in patients with PD than in HC (p < 0.05). Cognitive pretesting improved the preliminary GDQ so that the final GDQ was rated as relevant (100/100%), comprehensive (100/90%), easy to understand concerning questions and answer options (100/90%), and of appropriate length (80/100%) by neurologists and patients with PD, respectively. The GDQ demonstrated excellent internal consistency (Cronbach‘s alpha value of 0.94). Evidence for good construct validity is given by moderate to high correlations of the GDQ total score and its domains by intercorrelations (rs = 0.67–0.91; p < 0.001) and with validated general NMS measures as well as with specific items that assess gastrointestinal symptoms.InterpretationThe GDQ is a novel, easy, and quick 18-item self-assessment questionnaire to screen for and monitor gastrointestinal dysmotility with a focus on constipation in patients with PD. It has shown high acceptance and efficacy as well as good construct validity in cognitive pretests.

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Section: Discussionmentioning

confidence: 99%

The Gut Dysmotility Questionnaire for Parkinson's disease: Insights into development and pretest studies

et al. 2023

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“…Due to increased recognition of dysphagia even in early PD, the MDTPD questionnaire has been specifically validated for this purpose (Simons et al, 2014). Recently, the Gastrointestinal Dysfunction Scale for PD (GIDS-PD) has been developed as a self-report tool to quantitatively assess the presence and severity of GI dysfunction features, including dysphagia and sialorrhea, in patients with PD with strong reliability and validity (Camacho et al, 2021). Generic non-motor questionnaires, including Non-Motor Symptoms Questionnaire (NMSQuest) and Non-Motor Symptoms Scale (NMSS) may be helpful in this setting as it enables healthcare teams to determine the presence a diverse range of NMS, including GI issues, so that they can be referred for further investigation or treatment (Chaudhuri et al, 2006(Chaudhuri et al, , 2007.…”

Section: Recognition and Assessmentmentioning

confidence: 99%

Management of dysphagia and gastroparesis in Parkinson’s disease in real-world clinical practice – Balancing pharmacological and non-pharmacological approaches

Bhidayasiri

Phuenpathom

Tan

et al. 2022

Front. Aging Neurosci.

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Gastrointestinal (GI) issues are commonly experienced by patients with Parkinson’s disease (PD). Those that affect the lower GI tract, such as constipation, are the most frequently reported GI problems among patients with PD. Upper GI issues, such as swallowing dysfunction (dysphagia) and delayed gastric emptying (gastroparesis), are also common in PD but are less well recognized by both patients and clinicians and, therefore, often overlooked. These GI issues may also be perceived by the healthcare team as less of a priority than management of PD motor symptoms. However, if left untreated, both dysphagia and gastroparesis can have a significant impact on the quality of life of patients with PD and on the effectiveness on oral PD medications, with negative consequences for motor control. Holistic management of PD should therefore include timely and effective management of upper GI issues by utilizing both non-pharmacological and pharmacological approaches. This dual approach is key as many pharmacological strategies have limited efficacy in this setting, so non-pharmacological approaches are often the best option. Although a multidisciplinary approach to the management of GI issues in PD is ideal, resource constraints may mean this is not always feasible. In ‘real-world’ practice, neurologists and PD care teams often need to make initial assessments and treatment or referral recommendations for their patients with PD who are experiencing these problems. To provide guidance in these cases, this article reviews the published evidence for diagnostic and therapeutic management of dysphagia and gastroparesis, including recommendations for timely and appropriate referral to GI specialists when needed and guidance on the development of an effective management plan.

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“…However, before being diagnosed with PD, many patients reported gastrointestinal (GI) dysfunction, such as dysphagia, constipation, nausea and vomiting. 2 Furthermore, functional and structural changes in GI tissues, such as α-synuclein accumulation in the enteric nervous system (ENS) and impaired colonic mucosa barrier function, have also been observed in patients with Parkinson's disease. 3,4 Consistent with the occurrence of GI dysfunction, gut microbiota dysbiosis has also been recognized as a feature of PD.…”

Section: Introductionmentioning

confidence: 99%

The protective role of microbiota in the prevention of MPTP/P-induced Parkinson's disease by resveratrol

Jiang

et al. 2023

Food Funct.

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The Gastrointestinal Dysfunction Scale for Parkinson's Disease

Cited by 14 publications

References 65 publications

The Gut Dysmotility Questionnaire for Parkinson's disease: Insights into development and pretest studies

The Gut Dysmotility Questionnaire for Parkinson's disease: Insights into development and pretest studies

Management of dysphagia and gastroparesis in Parkinson’s disease in real-world clinical practice – Balancing pharmacological and non-pharmacological approaches

The protective role of microbiota in the prevention of MPTP/P-induced Parkinson's disease by resveratrol

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