Impact of the COVID-19 Pandemic on the Quality of Life of Patients with Parkinson’s Disease and Their Caregivers: A Single-Center Survey in Tochigi Prefecture

Abstract

Background: The coronavirus disease 2019 (COVID-19) pandemic has negatively affected the mental health of the general population. Objective: We investigated the determinants of quality of life (QOL) in Parkinson’s disease (PD) patients during the COVID-19 pandemic. Methods: Impacts of lifestyle changes due to the COVID-19 pandemic on 100 patients with PD and their caregivers/spouses were assessed. The Hospital Anxiety and Depression Scale was used to assess anxiety and depression. The physical component summary (PCS) and mental component summary (MCS) scores of the short form (SF)-8 were used to evaluate health-related QOL. Results: Regarding health-related QOL, physical function, role physical, general health, vitality and the PCS score were significantly worse in PD patients than in caregivers. Worsening of PD-related symptoms, increased stress, and decreased physical activity were observed in 29.0%, 37.0% and 44.0% of PD patients, respectively. Sixteen patients (16.0%) experienced problems with hospital access, but none reported medication shortages. Strong concerns about COVID-19 were reported by 47.0% of caregivers and 50.0% of PD patients. In PD patients, increased gait disturbance and rigidity, disease severity, smoking, the levodopa equivalent dose and decreased body weight predicted a worse PCS score; anxiety, depression, female sex, stress and long disease duration predicted a worse MCS score. In caregivers, age and smoking contributed to a worse PCS score; depression, stress and worsening patient mood contributed to a worse MCS score. Conclusion: We report the negative impacts of the COVID-19 pandemic on health-related QOL and its determinants in PD patients and their caregivers.

COVID-19 depression and its risk factors in Asia Pacific – A systematic review and meta-analysis

“… Sun et al, 2021 ), ( Tsang et al, 2021 ), (H. Wang et al, 2021 ), (Y. Wang et al, 2021 ), ( Wickens et al, 2021 ), ( Wu et al, 2021a ), (R. Yadav et al, 2021 ), ( Yan et al, 2021 ), ( Yasmin et al, 2021 ), ( Young et al, 2021 ) Gender 30 11.86 (Xu Chen et al, 2021 ), ( Chi et al, 2021 ), ( Devkota et al, 2021 ), ( Fang et al, 2021 ), ( Glenister et al, 2021 ), (Huang et al, 2021), ( Rashid et al, 2021 ), ( Kibbey et al, 2020 ), (S. Liu et al, 2021 ), ( Liu et al, 2020 ), ( Matsumoto et al, 2021 ), ( Moore et al, 2021 ), ( Nomura et al, 2021 ), ( Matsumoto et al, 2021 ), ( Moore et al, 2021 ), ( Nomura et al, 2021 ), ( Pandey et al, 2021 ), ( Parthasarathy et al, 2021 ), ( Peng et al, 2021 ), ( Robillard et al, 2021 ), ( Rossell et al, 2021 ), ( Safa et al, 2021 ), ( Sakib et al, 2021 ), ( Song et al, 2020 ), ( Suzuki et al, 2021 ), ( Turna et al, 2021 ), ( Veldhuis et al, 2021 ), (Y. Wang et al, 2021 ), ( Wong et al, 2021 ), ( Wu et al, 2021a ), (R. Yadav et al, 2021 ), ( Yan et al, 2021 ) Deterioration of medical problems/ medical condition/ diagnosed disease/ underlying disease 21 8.30 (J.…”

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Physical Activity and Health-Related Quality of Life in Adults With a Neurologically-Related Mobility Disability During the COVID-19 Pandemic: An Exploratory Analysis

“…Crosssectional data (n = 125) collected during the same time frame in the UK reported that 61% of children and young adults with physical and/or intellectual disabilities were less physically active as a result of lockdown restrictions (37). Outside of the UK, decreased PA was observed in 44% of Parkinson's disease patients in Japan (data collected over a wider timeframe between June and December 2020) (38). The COVID-19 quarantine in Italy significantly decreased total weekly PA levels (quantified via the International Physical Activity Questionnaire Short-Form before and during) in a sample of participants with neuromuscular disease (n = 149).…”

“…The median HAQ-SDI scores of our cohort (1.5) indicate the presence of disability (>1). Perhaps unsurprisingly, the HAQ-SDI score was lowest for participants without mobility aids but highest for individuals who used any mobility aid and performed less household PA. A subjective worsening of neurological symptoms has been reported in individuals with Parkinson's disease (38,43) amyotrophic lateral sclerosis (ALS) (44) and cerebellar ataxias (45) as a result of COVID-19 restrictions, increasing the socio-economic burden of these neurological conditions (46). Indeed, the restricted access to healthcare services (rehabilitation, community and home-based support) during the pandemic (31) for disabled individuals may detrimentally impact mobility and function.…”