The prevalence of psychiatric comorbidity in patients with prurigo nodularis

Dhawan, Lovee; Singh, Shubh Mohan; Kumaran, Muthu Sendhil; Narang, Tarun

doi:10.4103/idoj.idoj_324_17

Cited by 8 publications

(2 citation statements)

References 14 publications

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“…Many medical conditions such as atopic eczema, 14 cardiovascular and neurological diseases, 15 chronic kidney disease, 16 anxiety disorders and subsets of diabetes mellitus, 17 infections (especially HIV) 18 and mental disorders 2,19–21 are reportedly associated with PN disease.…”

Section: Introductionmentioning

confidence: 99%

“…8,11,12 The pathophysiology of PN is not entirely understood, though a hypothesis suggests that PN pathogenesis could be associated with a neuroimmune crosstalk, Th1 to Th3 inflammation, neural hypersensitivity and involvement of mast cell, and Merkel cell neurite complexes. 13 Many medical conditions such as atopic eczema, 14 cardiovascular and neurological diseases, 15 chronic kidney disease, 16 anxiety disorders and subsets of diabetes mellitus, 17 infections (especially HIV) 18 and mental disorders 2,[19][20][21] are reportedly associated with PN disease.…”

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confidence: 99%

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Comorbidities, healthcare resource utilization & treatment pattern among patients with prurigo nodularis, compared to a benchmark in Germany: A real‐world evidence claims data study

Ständer,

Ketz,

Akumo

et al. 2023

Acad Dermatol Venereol

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BackgroundPrurigo nodularis (PN) is a rare chronic inflammatory skin disease with a high disease burden, but data on clinical and economic burden are still scarce.ObjectiveTo describe the real‐world epidemiologic, clinical and therapeutic characteristics and related economic burden of patients with PN compared to a benchmark population in Germany.MethodsThis retrospective study was based on an excerpt of German Statutory Health Insurance data of patients with an initial PN diagnosis between 2012 and 2016. PN cohort contained no record of PN in eight quarters before the index quarter and was followed up for eight quarters (unless deceased). Benchmark cohort without PN was calculated using direct standardization and 1:1 matching to PN cohort.ResultsOut of 4,536,002 insured patients, 2309 incident patients with PN were identified and matched to the benchmark cohort out of 3,018,382 patients without PN. Patients were mostly between 45 and 80 years when diagnosed with PN. Higher comorbidity rates were reported for PN than benchmark, with a rising disease burden at follow‐up. Most patients with PN (91.3%) were diagnosed outpatient and had >50% more outpatient visits than the benchmark cohort. Hospitalization rates were higher in PN (53.9%) versus benchmark (35.1%), yielding twice longer mean hospital stays for PN (12 days) compared to benchmark (6 days) (p < 0.001). The most common initial therapy for patients with PN was topical corticosteroids (47.6%); ≥10% of patients were treated with antidepressants, antihistamines or systemic corticosteroids. Therapy rates were higher for PN compared to benchmark (p < 0.001). Mean initial costs were twofold higher in PN versus benchmark for outpatient, inpatient and drugs. During follow‐up, an increase of >70% in mean PN costs compared to benchmark was identified for outpatient, inpatient and concomitant treatments (p < 0.001).ConclusionThis study highlights the significantly higher clinical and economic burden incurred by PN compared to benchmark patients in Germany, reflecting the unmet medical need for PN.

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