The prevalence and odds of anxiety and depression in children and adults with hidradenitis suppurativa: Systematic review and meta-analysis

Jalenques, Isabelle; Ciortianu, Laura; Pereira, Bruno; D’Incan, M.; Lauron, Sophie; Rondepierre, Fabien

doi:10.1016/j.jaad.2020.03.041

Cited by 47 publications

(41 citation statements)

References 58 publications

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“…In our cohort, the frequency of diabetes (2.8%) and arterial hypertension (3.8%) was not greater than that recorded in the French general population, unlike in previously published data [17,35]. Overall, 6.6% of participants declared having depression, which is low compared with other studies [54]. Inflammatory bowel disease was declared by 4.8% of participants and spondylarthritis by 3.8%, which is similar to the data of Richette et al [55] (prevalence 3.7%), and the prevalence exceeded that in the general population.…”

Section: Discussioncontrasting

confidence: 94%

Baseline Characteristics of a National French E-Cohort of Hidradenitis Suppurativa in ComPaRe and Comparison with Other Large Hidradenitis Suppurativa Cohorts

et al. 2021

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Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition substantially impacting patients’ quality of life; the pathogenesis remains unclear, and treatment is complex and not yet standardized. Observational data are increasingly being used to evaluate therapeutics in “real-life” interventions, and the development of e-cohorts is offering new tools for epidemiological studies at the population level. Objective: The aim of this study was to describe the clinical characteristics and treatment history of HS participants in the Community of Patients for Research (ComPaRe) cohort and to compare these to other cohorts. Methods: We performed a cross-sectional study of the baseline data of HS participants in ComPaRe, an e-cohort of patients with chronic diseases. Data were collected using patient-reported questionnaires about clinical-demographic aspects, quality of life, and treatment history. Results: A total of 396 participants (339 females, 57 males) were included (mean age 38 years); 83 (21%) had a family history of HS, 227 (57.3%) were current smokers, and 241 (60.9%) were overweight or obese. Most of the participants declared a Hurley stage II (n = 263, 66.4%) or III (n = 76, 20.3%). The breast was more frequently affected in women than men (37.5 vs. 5.3%, p < 0.0001), whereas the dorsal region was more frequently affected in men (39.5 vs. 10.9%, p < 0.0001). Increased disease stage was associated with obesity (25.9 vs. 33.8 vs. 51.3%, p = 0.02) and some HS localizations (genital [p < 0.005], pubis [p < 0.007], gluteal fold [p = 0.02], and groin [p < 0.0001]). The most frequently prescribed treatments were oral antibiotics (n = 362, 91.4%), especially amoxicillin-clavulanic acid and cyclins. Less than 10% of participants received biologics. Most of these results were consistent with previously published cohorts. Conclusion: Recruitment of participants by such a web platform can be a faster way to get relevant scientific data for a wide variety of patients that could be used for epidemiological studies and to evaluate therapeutics in “real-life” interventions.

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Section: Discussioncontrasting

confidence: 94%

Baseline Characteristics of a National French E-Cohort of Hidradenitis Suppurativa in ComPaRe and Comparison with Other Large Hidradenitis Suppurativa Cohorts

et al. 2021

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“…In keeping with HS being a socially isolating, painful chronic condition, a systematic review and meta-analysis revealed a high prevalence of depression, 21%, in those with HS. 35 An analysis of nine case-control studies gave an OR for the association between HS and depression of 1Á99 (95% CI 1Á63-2Á43). There was a similar association between HS and anxiety, with a prevalence of 12% and a pooled OR of 1Á97 (95% CI 1Á65-2Á35).…”

Section: Mental Healthmentioning

confidence: 99%

The epidemiology of hidradenitis suppurativa*

Ingram¹

2020

Br. J. Dermatol.

123

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Summary Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease defined clinically by multiple, painful inflammatory lesions occurring predominantly in flexural sites. Onset is typically soon after puberty; however, it remains unknown whether the menopause induces remission. In North American and European patients with HS the female‐to‐male ratio is approximately 3 : 1 but the ratio is 1 : 2 in South Korean patients. It may be that some elements of HS epidemiology cannot be generalized across all populations. Elements of HS epidemiology in the USA and Europe are well established, including strong associations with obesity and smoking, which may increase disease severity. There are associations between HS and other cardiovascular disease (CVD) risk factors, including type 2 diabetes and metabolic syndrome. People with HS have double the risk of death from CVD compared with those without HS and 1·5 times the risk compared with patients with psoriasis. Depression and anxiety are associated with HS and completed suicide rates in those with HS are more than double the rates in controls. Associations exist between HS and other chronic inflammatory conditions, particularly inflammatory bowel disease and inflammatory arthritis. Case–control studies demonstrate associations with pilonidal sinus, polycystic ovary syndrome, Down syndrome, obstructive sleep apnoea and pyoderma gangrenosum. Population‐based studies using routinely collected healthcare data from the USA estimate a prevalence of 0·1%, suggesting HS is relatively uncommon. European studies include undiagnosed patients and typically estimate prevalence of 1% or more, suggesting a common condition. Resolving the controversy surrounding a greater than 10‐fold difference in HS prevalence estimates remains a high priority.

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“…In congruence with our results, a systematic review showed a prevalence of 21% for depression and 12% for anxiety in patients with HS. 3 Compared with the study by Wright et al, 1 it is a limitation of our study that we did not include a control group. Also, we included data from only a single center and had no data on substance abuse.…”

Section: Occurrence and Risk Factors Of Depression In Patients With Hmentioning

confidence: 88%

Occurrence and risk factors of depression in patients with hidradenitis suppurativa

Jørgensen

Holm

Yao

et al. 2020

Journal of the American Academy of Dermatology

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The prevalence and odds of anxiety and depression in children and adults with hidradenitis suppurativa: Systematic review and meta-analysis

Cited by 47 publications

References 58 publications

Baseline Characteristics of a National French E-Cohort of Hidradenitis Suppurativa in ComPaRe and Comparison with Other Large Hidradenitis Suppurativa Cohorts

Baseline Characteristics of a National French E-Cohort of Hidradenitis Suppurativa in ComPaRe and Comparison with Other Large Hidradenitis Suppurativa Cohorts

The epidemiology of hidradenitis suppurativa*

Occurrence and risk factors of depression in patients with hidradenitis suppurativa

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