The prevalence of oral squamous cell carcinoma with oral submucous fibrosis

Saalim, Mohd; Sansare, Kaustubh; Karjodkar, Freny; Johaley, Satyapal; Ali, Ibrahim K; Sharma, Sneha R; Mehra, Archana; Rahman, Bushra

doi:10.4103/jcrt.jcrt_719_19

Cited by 11 publications

(10 citation statements)

References 16 publications

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“…However, in the study of Salam et al 13 , OSMF was dominant in 2 nd decade of life. Similar findings were reported by Saalim et al 18 , Hosein et al 19 According to Merchant et al 20 , two decades ago mean age of presentation of OSMF in Pakistan was 48.8±11.6 whereas, in current study the mean age was 30.26±14.12 years. This shows an alarming shift of incidence of OSMF from 4 th decade to 3 rd decade of life, which might ultimately progress to early malignant transformations resulting in high incidence of OSCC leading to increased morbidity and mortality.…”

Section: Discussionsupporting

confidence: 90%

“…In the present study, there were 59.04% males and 40.96% females with male to female ratio being 1.4:1 which is similar to findings of Tariq et al 17 , Hosein et al 19 , and Memon et al 21 conducted in Pakistan. However, these findings are inconsistent with recent literature in India as reported by Saalim et al 18 and Gondivkar et al 22 , where male to female ratio was 6.4:1 and 7.5:1 respectively. Kumar 15 reported male to female ratio of 21.3:1.…”

Section: Discussioncontrasting

confidence: 76%

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Influence of Risk Habits on Demographic Factors and its Impact on Oral Submucous Fibrosis

Rashid¹,

Manzar²,

Kazmi³

et al. 2021

PJMHS

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Objective: To establish a correlation and evaluate paradigm shift of demographic parameters in oral submucous fibrosis patients due to use of areca nut and tobacco. Study Design: Cross sectional study. Place and Duration of the Study: Outpatient Department of Tertiary Care Teaching Hospital, Lahore from 1st November 2019 to 30th June 2021. Methodology: All patients with compliant of limited mouth opening and diagnosed clinically with oral submucous fibrosis were included. Biographical data was collected based on age, gender, literacy rate, socioeconomic conditions and habit of consumption of areca nut-based products and tobacco. Results: Prevalence of OSMF was 0.45% with mean age of 29.26±14.12 years. Areca nut alone is consumed more by females (44.12%) whereas combination of tobacco and areca nut use was higher in males (87.76%). Risk habits were found to be highest in uneducated/primary education (63.01%) and in low socioeconomic group (59.03%). Conclusion: Comparing the last two decades, there is paradigm shift in age of contracting OSMF towards younger age. Significant finding of areca nut use by females also draws attention for control measures. Harmful effects of areca nut and tobacco products should be highlighted and included in educational and community programs. Keywords: Oral submucous fibrosis, Potentially malignant disorders, Areca nut, Oral squamous cell carcinoma

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Section: Discussionsupporting

confidence: 90%

Section: Discussioncontrasting

confidence: 76%

Influence of Risk Habits on Demographic Factors and its Impact on Oral Submucous Fibrosis

Rashid¹,

Manzar²,

Kazmi³

et al. 2021

PJMHS

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“…As, these tumors are often associated with impacted teeth, the possibility of eruption of the impacted tooth, after a supposed obstructive odontoma has been surgically removed remains an important issue. Corticosteroids can be administered after surgical removal of odontoma to reduce post surgical pain as corticosteroids are a class of compounds secreted endogenously by the adrenal cortex and manufactured as synthetic analogues for therapeutic use, predominantly because of their powerful anti-inflammatory and immunosuppressive properties [18][19][20] . In children, the impacted permanent teeth, depending on the age of the child and the stage of tooth development, may be left to erupt by itself or may be guided to occlusion via orthodontic traction [3,4] .…”

Section: Discussionmentioning

confidence: 99%

Unusually Large Erupted Complex Odontoma in Anterior Maxilla

Khanna¹,

Ali²

2023

Int J Health Sci Res

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Odontoma or odontome is the most common odontogenic tumor in oral cavity. Complex odontomas are commonly found in the posterior mandible region. Complex odontoma or fibro odontoma is most commonly located in anterior maxilla. Odontoma are hamartoma comprised of various dental tissues, that is, enamel, dentin, cementum, and occasionally pulp. Odontoma are slow-growing, benign tumors. The World Health Organization (WHO) outlines odontomas as two types-complex odontoma and compound odontoma. Complex odontoma very rarely erupts in the oral cavity. We report this interesting case of a large erupted complex odontoma in anterior maxilla. Key words: odontoma, odontome, complex odontome, benign tumor, fibro odontoma, odontogenic tumor, hamartoma

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“…The SALL4 gene forms a regulatory network with other stem cellrelated genes (such as OCT-4, NANOG, Sox2, etc.) and plays a crucial role in embryonic development and formation (11). Mutation of the SALL4 gene can lead to the occurrence of a variety of genetic diseases (12).…”

Section: Original Articlementioning

confidence: 99%

Study on the mechanism of SALL4 down-regulation in promoting the invasion and migration of oral squamous cell carcinoma and influencing the survival and prognosis of patients

Li¹,

Zhang²,

Xu³

et al. 2022

Ann Transl Med

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Background: To investigate the identification of spalt-like transcription factor 4 (SALL4) in oral squamous cell carcinoma (OSCC).Methods: Recombinant cells loaded with miRNA expression cells were used to transform Tca8113 cells. Simple Tca8113 cells were used as the control group. We detected SALL4 messenger RNA (mRNA) before and after transfection by reverse transcription polymerase chain reaction (RT-PCR) and protein immunoblotting (western blot) A and protein expression. A dual luciferase reporter system was used to verify the targeted regulation of SALL4 and identify miRNA-S to test the effect of miRNA related to SALL4 regulation on the invasion and metastatic ability of Tca8113 cells. Results:The expression of SALL4 mRNA in Tca8113 cells was higher than that in the downregulated and control groups, respectively (P<0.05); there was no difference in Tca8113 cells between the upregulated and downregulated groups (P>0.05). Dual luciferase reporter system showed that the identified miRNA was miRNA-S; there were no differences in migration and invasion of Tca8113 cells between the up-and downregulated groups (P>0.05). Conclusions:In human OSCC, SALL4 regulation-related miRNAs are poorly expressed and can inhibit the invasion and metastasis of tumor cells, which is expected to become a new therapeutic target for OSCC.

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The prevalence of oral squamous cell carcinoma with oral submucous fibrosis

Cited by 11 publications

References 16 publications

Influence of Risk Habits on Demographic Factors and its Impact on Oral Submucous Fibrosis

Influence of Risk Habits on Demographic Factors and its Impact on Oral Submucous Fibrosis

Unusually Large Erupted Complex Odontoma in Anterior Maxilla

Study on the mechanism of SALL4 down-regulation in promoting the invasion and migration of oral squamous cell carcinoma and influencing the survival and prognosis of patients

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