The Prevalence of Multidrug Resistance of Helicobacter pylori and Its Impact on Eradication in Korea from 2017 to 2019: A Single-Center Study

Park, Jae Yong; Shin, Tae-Seop; Kim, Ji Hyun; Yoon, Hong Jip; Kim, Beom Jin; Kim, Jae Gyu

doi:10.3390/antibiotics9100646

Cited by 20 publications

(27 citation statements)

References 30 publications

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“…18 A moderate resistance rate was detected in France (58.6%) 23 and Korea (27%). 24 The high resistance rates may be due to the widespread use of metronidazole for other infectious diseases, such as parasitic intestinal infections and genital infections. Metronidazole is cheap and overused and is an over-the-counter drug in developing countries such as Egypt.…”

Section: Discussionmentioning

confidence: 99%

“…A very low rate of resistance was reported in France (0% using PCR) 23 and China (1.6% using E-test). 26 Slightly higher resistance rates were detected in China 18 (7.7% using the disk diffusion or E-test), Palestine (18%), 22 Egypt (18.3% using PCR), 27 Korea (20%), 24 and Iran (30% using the E-test). 28 The different amoxicillin resistance rates may be due to the different geographical areas or the different methods of testing resistance.…”

Section: Discussionmentioning

confidence: 99%

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Helicobacter pylori Antibiotic Resistance in Egypt: A Single-Center Study

Metwally¹,

Ragab²,

Hamid³

et al. 2022

IDR

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Helicobacter pylori (H. pylori) is the most common human bacterial infection worldwide, infecting approximately half of the world's population. Although antibiotic use is indicated for H. pylori eradication, the recommended type of antibiotic varies from country to country according to the H. pylori resistance pattern; developing countries, such as Egypt, may have different patterns than developed countries. We evaluated the antibiotic resistance of H. pylori in Egypt. Methods: This cross-sectional study included 134 adult patients with upper gastrointestinal (GI) complaints. Patients with a history of PPI during the last 2 weeks or antibiotics during the last 4 weeks before endoscopy were excluded. Upper GI endoscopies were performed and biopsies were collected for histopathology and H. pylori culture. Demographic, clinical, and endoscopic data were also collected. Antimicrobial susceptibility testing for H. pylori was performed for nine therapeutically relevant antibiotics using the Kirby-Bauer disc diffusion method. Results: The H. pylori antibiotic resistance rates were as follows: moxifloxacin, 10%; doxycycline, 15%; levofloxacin, 20%; clarithromycin, 40%; azithromycin, 40%; erythromycin, 65%; rifampicin, 90%; amoxicillin, 95%; and metronidazole, 100%. Dual resistance rates were 40% for amoxicillin/clarithromycin, 40% for metronidazole/clarithromycin, and 95% for amoxicillin/metronidazole. Conclusion:In Egyptian patients, H. pylori had >90% resistance to metronidazole and amoxicillin; modest resistance to erythromycin, azithromycin, and clarithromycin; and low resistance to moxifloxacin, and levofloxacin (≤20%). Dual resistance was high for amoxicillin/clarithromycin and amoxicillin/metronidazole, which prefers using quinolones rather than clarithromycin or metronidazole for first-line treatment of H. pylori in Egypt.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori Antibiotic Resistance in Egypt: A Single-Center Study

Metwally¹,

Ragab²,

Hamid³

et al. 2022

IDR

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“…The efficacy of lansoprazole, bismuth, levofloxacin, and amoxicillin therapy compared to bismuth metronidazole tetracycline (BMT) quadruple therapy for second-line treatment of H. pylori. Studies found that sequential and hybrid therapies have found to be better eradication rate 24 , 25 in their studies showed triple and quadruple regimens patients with no compliance 2,25, In study done in Korea 18 , antibiotic resistance to clarithromycin has been reported 15%. Resistance against both clarithromycin and metronidazole reported was 8.6%.…”

Section: Discussionmentioning

confidence: 98%

Helicobacter Pylori Infection and Frequency of Clarithromycin Resistance by qPCR

Khan¹,

Ghani²,

Izhar³

et al. 2022

J. Bahria Uni. Med. Dent. Coll.

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Objective: Determine the frequency of Helicobacter pylori (H. pylori) infection in our population, the response to triplequadruple regimen and resistance to clarithromycin. Study Design and Setting: Study design is case-series, Medicare Cardiac & General Hospital, Karachi- 2020-2021. All patients (N=110) were selected from outpatient department (OPD) of the Jinnah Medical College Hospital (JMCH) and Medicare Cardiac and General Hospital. Methodology: Patients with nausea, abdominal pain, diarrhea and IgG positive were included, and ELISA was done for detection of H. pylori infection.. IgG negative for H. pylori and having other gastrointestinal infections were excluded from this study. Patients positive with infection were prescribed the initial triple /quadruple regimen (triple regimen therapy including Proton pump inhibitor (PPI) 20 mg, Metronidazole 400mg, Amoxicillin 250 mg or Quadruple therapy by adding Bismuth subsalicylate). In ten cases of relapse Sequential / Rescue therapy were continued after a gap of 6 weeks included PPI 20 mg, metronidazole 400mg ciprofloxacin 200mg BD or Levofloxacin 400 mg OD. The qPCR was performed for the detecting resistant to clarithromycin in patients with H. pylori IgG positive after therapy. Result: During the follow-up, 60 (54%) cases were recovered from initial triple regimen, whereas 40(36%) cases recovered quadruple therapy and remaining 10 (7%) had clarithromycin resistance and were prescribed sequential therapy replacing clarithromycin by fluoroquinolones. Conclusion: The study showed that majority of H. pylori infected patient in our population recovered from initial triple/quadruple regimen. The alternate option with clarithromycin resistant was sequential and rescue therapy with high eradication rate

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“…It is very important to have a good understanding of regional antibiotic resistance patterns of H. pylori for the implementation of effective empirical eradication therapies and adequate rescue therapies. The study conducted by Park and coworkers investigated the antibiotic resistance patterns of H. pylori and their impact on eradication in Seoul in recent years [ 13 ]. Their results suggested alarming data: the rate of multidrug resistance is increasing, and standard triple therapy (STT) is no longer an acceptable first-line option for H. pylori eradication in Korea.…”

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confidence: 99%