Spread of Multidrug-Resistant Microorganisms

Lodovico, Silvia Di; Fasciana, Teresa; Giulio, Mara Di; Cellini, Luigina; Giammanco, Anna; Rossolini, Gian María; Antonelli, Alberto

doi:10.3390/antibiotics11070832

Cited by 7 publications

(6 citation statements)

References 14 publications

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“…In recent years, the prevalence of bacterial infectious diseases and global public health emergencies due to multidrug-resistant bacteria has substantially increased. 1,2 Many studies have reported the synthesis of modern antimicrobial agents. 3,4 However, bacterial adaptation to drugs remains a challenging problem.…”

Section: Introductionmentioning

confidence: 99%

Green synthesis of M-type manganese-substituted strontium hexaferrite SrMn_xFe_12−xO₁₉ nanoparticles with intrinsic antibacterial activity against human pathogenic bacteria

Hamarawf,

Tofiq,

Omer

2023

New J. Chem.

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Section: Introductionmentioning

confidence: 99%

Green synthesis of M-type manganese-substituted strontium hexaferrite SrMn_xFe_12−xO₁₉ nanoparticles with intrinsic antibacterial activity against human pathogenic bacteria

Hamarawf,

Tofiq,

Omer

2023

New J. Chem.

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“…MDROs are usually found in hospital settings where there is constant use of antibiotics. However, they are now appearing in rural and urban settings outside of healthcare facilities 47 , 48 . Colonization by MDROs does not equate to disease, but it does increase risk of infection 49 and dissemination in high EHI communities due to low SES and crowded housing 50 .…”

Section: Discussionmentioning

confidence: 99%

Neighborhood socioeconomic status is associated with low diversity gut microbiomes and multi-drug resistant microorganism colonization

Zuniga-Chaves,

Eggers,

Kates

et al. 2023

npj Biofilms Microbiomes

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Social disparities continue to limit universal access to health care, directly impacting both lifespan and quality of life. Concomitantly, the gut microbiome has been associated with downstream health outcomes including the global rise in antibiotic resistance. However, limited evidence exists examining socioeconomic status (SES) associations with gut microbiome composition. To address this, we collected information on the community-level SES, gut microbiota, and other individual cofactors including colonization by multidrug-resistant organisms (MDROs) in an adult cohort from Wisconsin, USA. We found an association between SES and microbial composition that is mediated by food insecurity. Additionally, we observed a higher prevalence of MDROs isolated from individuals with low diversity microbiomes and low neighborhood SES. Our integrated population-based study considers how the interplay of several social and economic factors combine to influence gut microbial composition while providing a framework for developing future interventions to help mitigate the SES health gap.

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“…MDROs have become one of the most important threats to public health worldwide. [1] Urinary tract infections (UTIs) are the second most common infectious disease after respiratory tract infections and are one of the main types of MDRO infection. [2] UTIs occur in all ages and both genders, and involve inflammation of the urinary tract, which is characterized by a high incidence, high recurrence rate, high cost of antibiotics, and a lack of consensus on appropriate antimicrobial therapy.…”

Section: Introductionmentioning

confidence: 99%

Risk factors and economic burden for community-acquired multidrug-resistant organism-associated urinary tract infections: A retrospective analysis

Bian,

Zhu,

Fang

et al. 2024

Medicine

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The spread of multidrug-resistant organisms (MDROs) has resulted in a corresponding increase in the incidence of urinary tract infections (UTIs). The risk factors and hospitalization burden for community-acquired MDRO-associated UTIs are discussed herein. This retrospective study included 278 patients with community-based MDRO-associated UTIs from January 2020 to January 2022. The MDRO (n = 139) and non-MDRO groups (n = 139) were separated based on drug susceptibility results. Community-based MDRO-associated UTIs mainly occurred in the elderly and frail patients with a history of invasive urinary tract procedures. The MDRO group imposed a greater economic burden compared to the non-MDRO group. Independent risk factors for community-based MDRO-associated UTIs were as follows: white blood cell (WBC) count > 10.0 × 109/L (OR = 2.316, 95% CI = 1.316–3.252; P = .018); ≥3 kinds of urinary tract obstructive diseases (OR = 1.720, 95% CI = 1.004–2.947; P = .048); use of 3rd generation cephalosporins (OR = 2.316, 95% CI = 1.316–4.076; P = .004); and a history of invasive urologic procedures (OR = 2.652, 95% CI = 1.567–4.487; P < .001). Days of hospitalization, antibiotic use, and bladder catheter use were significantly greater in the MDRO group than the non-MDRO group (P < .05).

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Spread of Multidrug-Resistant Microorganisms

Abstract: Multidrug-resistant organisms (MDRO) are bacteria that exhibit acquired resistance to multiple antibiotics, reducing the efficacy of antimicrobial therapies [...]

Cited by 7 publications

References 14 publications

Green synthesis of M-type manganese-substituted strontium hexaferrite SrMn_xFe_12−xO₁₉ nanoparticles with intrinsic antibacterial activity against human pathogenic bacteria

Green synthesis of M-type manganese-substituted strontium hexaferrite SrMn_xFe_12−xO₁₉ nanoparticles with intrinsic antibacterial activity against human pathogenic bacteria

Neighborhood socioeconomic status is associated with low diversity gut microbiomes and multi-drug resistant microorganism colonization

Risk factors and economic burden for community-acquired multidrug-resistant organism-associated urinary tract infections: A retrospective analysis

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Spread of Multidrug-Resistant Microorganisms

Abstract: Multidrug-resistant organisms (MDRO) are bacteria that exhibit acquired resistance to multiple antibiotics, reducing the efficacy of antimicrobial therapies [...]

Cited by 7 publications

References 14 publications

Green synthesis of M-type manganese-substituted strontium hexaferrite SrMnxFe12−xO19 nanoparticles with intrinsic antibacterial activity against human pathogenic bacteria

Green synthesis of M-type manganese-substituted strontium hexaferrite SrMnxFe12−xO19 nanoparticles with intrinsic antibacterial activity against human pathogenic bacteria

Neighborhood socioeconomic status is associated with low diversity gut microbiomes and multi-drug resistant microorganism colonization

Risk factors and economic burden for community-acquired multidrug-resistant organism-associated urinary tract infections: A retrospective analysis

Contact Info

Product

Resources

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Green synthesis of M-type manganese-substituted strontium hexaferrite SrMn_xFe_12−xO₁₉ nanoparticles with intrinsic antibacterial activity against human pathogenic bacteria

Green synthesis of M-type manganese-substituted strontium hexaferrite SrMn_xFe_12−xO₁₉ nanoparticles with intrinsic antibacterial activity against human pathogenic bacteria