The prevalence of HLA alleles in a lupus nephritis population

Holanda, Maria Izabel de; Klumb, Evandro Mendes; Imada, Alicia; Lima, Livia A.; Alcântara, Isabela; Gregório, Flavia; Christiani, Lydia; Martins, Clarice Oliveira; Timoner, Branca Engel; Motta, Juliana; Pozzan, Roberto; Porto, Luís Cristóvão

doi:10.1016/j.trim.2018.02.001

Cited by 16 publications

(8 citation statements)

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“…HLA class II alleles have been repeatedly shown to display strong associations with SLE across the major histocompatibility complex region, particularly in the DRB1 and DQB1 loci. In the current study, we observed that HLA-DRB1*15 and DQB1*03 alleles were the most important susceptibility and protective variants for SLE in Malays and other ethnic groups,9 11 13–18 20 29–31 34–38 40–43 suggesting that the genetic effects of these alleles are generalised to multiple ethnic populations of Caucasian, African and Asian descent.…”

Section: Discussionmentioning

confidence: 51%

“…Noticeably, we identified that the B*38:02 allele was significantly associated with risk of SLE (OR=2.51), which has not been reported in previous studies. In Caucasians, several reports have consistently demonstrated that the HLA-B*08/*08:01 was significantly increased in patients with SLE 31 32 35. It is noteworthy that HLA-B*08 is one of the alleles residing within the ‘autoimmune’ haplotype 8.1 (HLA-A1/B8/Cw*07/DRB1*03:01/DQB1*02:01) that has shown to be associated with SLE particularly among the Caucasians 46.…”

Section: Discussionmentioning

confidence: 99%

“…To determine the generalisability or universal HLA risk factors for SLE development across different ethnic populations worldwide, we compared the current findings with the published significant SLE-associated HLA alleles from different populations/ethnic groups (ie, Caucasians,9–12 29–35 African13 36 37 and Asians14–18 20 21 38–43). We restricted our selection of published SLE-associated HLA risk factors which were genotyped by molecular methods.…”

Section: Methodsmentioning

confidence: 99%

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Human leucocyte antigens profiling in Malay female patients with systemic lupus erythematosus: are we the same or different?

et al. 2022

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ObjectiveSLE is a heterogeneous autoimmune disease, in terms of clinical presentation, incidence and severity across diverse ethnic populations. We investigated the human leucocyte antigens (HLA) profile (ie, HLA-A, HLA-B and HLA-C, HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1 and HLA-DPB1) in Malaysian Malay female patients with SLE and determined the generalisability of the published HLA risk factors across different ethnic populations globally including Malaysia.MethodsOne hundred Malay female patients with SLE were recruited between January 2016 and October 2017 from a nephrology clinic. All patients were genotyped for HLA-A, HLA-B, HLA-C, HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1 and HLA-DPB1 alleles using PCR sequence-specific oligonucleotides method on Luminex platform. A total of 951 HLA genotyped population-based Malay control subjects was used for association testing by means of OR with 95% CIs.ResultsOur findings convincingly validated common associations between HLA−A*11 (OR=1.65, p=3.36×10−3, corrected P (Pc)=4.03×10−2) and DQB1*05:01 (OR=1.56, p=2.02×10−2, Pc=non−significant) and SLE susceptibility in the Malay population. In contrast, DQB1*03:01 (OR=0.51, p=4.06×10−4, Pc=6.50×10−3) were associated with decreased risk of SLE in Malay population. Additionally, we also detected novel associations of susceptibility HLA genes (ie, HLA-B*38:02, DPA1*02:02, DPB1*14:01) and protective HLA genes (ie, DPA1*01:03). When comparing the current data with data from previously published studies from Caucasian, African and Asian populations, DRB1*15 alleles, DQB1*03:01 and DQA1*01:02 were corroborated as universal susceptibility and protective genes.ConclusionsThis study reveals multiple HLA alleles associated with susceptibility and protection against risk of developing SLE in Malay female population with renal disorders. In addition, the published data from different ethnic populations together with our study further support the notion that the genetic effects from association with DRB1*15:01/02, DQB1*03:01 and DQA1*01:02 alleles are generalised to multiple ethnic populations of Caucasian, African and Asian descents.

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Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Human leucocyte antigens profiling in Malay female patients with systemic lupus erythematosus: are we the same or different?

et al. 2022

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“…HLA-DR2 y HLA-DR3 elevan el riesgo de LES en caucásicos por dos a tres veces 8 . En latinos con nefritis lúpica se describe mayor prevalencia de HLA-B*08, DRB1*08, y DRB1*15 9 .…”

Section: Resultsunclassified

Juvenile Systemic Lupus Erythematosus and hematological compromise

Galeano

Ayala

Rolón

2020

Rev. parag. reumatol

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Introduction: Systemic Lupus Erythematosus (SLE) is a chronic inflammatory autoimmune disease of unknown cause without specificity for a particular organ. Juvenile SLE (jSLE) affects a greater number of organs and systems and presents a more aggressive clinical course than in adults. Hematological alterations could be presented as the only manifestation of SLE, so a detailed and systemic approach should be performed in these patients, once other causes such as infections and neoplasms have been excluded. objectives: To determine the hematological compromise in patients diagnosed with jSLE in the Pediatric Service of the Faculty of Medical Sciences of the National university of Asunción; over a period of 5 years. Materials and Methods: Retrospective, observational, descriptive, cross-sectional study. Non-probability sampling of consecutive jSLE cases diagnosed or under follow-up from January 2012 to May 2017. Results: Of the 73 patients, 57 women (78%) and 16 (22%) men were found, with an F:M ratio of 3.5:1. Average age at diagnosis was 11.9 years (SD: 3.65, range between 2 and 17 years). Regarding origin, 39 patients (53%) came from the Capital and Central Department and 34 cases (46%) from rural areas. The mean time between onset of symptoms and clinical diagnosis was 2 months (SD 1.27 months). Symptoms at first consultation were: arthralgias in 38 patients (52%), fever in 14 cases (19.2%), cutaneous-mucosal manifestations in 10 patients (13.7%), neurological manifestations in 5 cases (6.8%), edema in 4 patients (5.5%) and constitutional manifestations in 2 patients (2.7%). Hematologic abnormalities were found in 62 patients (85%), with a single series affected in 25 cases (40.3%), bicytopenia in 33 patients (53.2%), and pancytopenia in 4 patients (6.5%). The most frequent alterations were: anemia in 58 patients (79.4%), lymphopenia in 27 cases (36.9%), thrombocytopenia in 21 patients (28.4%) and leukopenia in 17 cases (23.2%). 60% of patients had more than one affected series. On the subject of anemia (n=58), 16 patients (27.6%) had a direct positive Coombs test and 42 patients (72.4%) had a direct negative Coombs test. Concerning hematimetric indices, 40 patients (69%) presented normochromic normocytic anemia and 18 patients (31%) hypochromic microcytic anemia. Conclusion: Hematological alterations were a frequent finding as a initial manifestation of SLE. Most cases had involvement of two series, with non-hemolytic anemia being the predominant finding. Laboratory tests are of great value when evaluating a patient with suspected autoimmune disease, since the results can confirm the diagnosis, estimate the severity of the disease, assess the prognosis and monitor SLE activity.

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“…[ 7 12 ] In fact, individuals with certain human leukocyte antigen (HLA) genotypes, such as HLA-B and HLA-DRB1, are found to have an increased tendency to develop both diseases. [ 42 43 44 45 ] Nonetheless, common susceptibility locus and single nucleotide polymorphisms (SNPs) in HLA genes are yet to be found.…”

Section: Discussionmentioning

confidence: 99%

Association of atopic dermatitis with an increased risk of systemic lupus erythematosus

Ponvilawan

Charoenngam

Wongtrakul

et al. 2021

Journal of Postgraduate Medicine

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Context: Previous studies on the association between atopic dermatitis (AD) and systemic lupus erythematosus (SLE) have yielded inconsistent results. Aims: To investigate the relationship between atopic dermatitis and systemic lupus erythematosus. Settings and Design: Systematic review and meta-analysis. Materials and Methods: A systematic review was conducted on EMBASE and MEDLINE databases from inception to March 2020 using a search strategy that consisted of terms related to AD and SLE. Eligible study must be either cohort or case-control study. For cohort studies, they must include patients with AD and comparators without AD, then follow them for incident SLE. For case-control studies, they must include cases with SLE and controls without SLE and examine their prior history of AD. Statistical Analysis Used: Meta-analysis of the studies was performed using a random-effect, generic inverse variance method to combine effect estimate and standard error. Funnel plot was used to assess publication bias. Results: A total of 21,486 articles were retrieved. After two rounds of review by three investigators, six case-control studies were qualified for the meta-analysis. The case-control study meta-analysis found a significantly increased odds of SLE among patients with AD with the pooled odds ratio of 1.46 (95% CI, 1.05–2.04). Conclusions: A significant association between AD and increased odds of SLE was observed by this systematic review and meta-analysis.

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The prevalence of HLA alleles in a lupus nephritis population

Abstract: This study demonstrated that the presence of HLA-DRB1*15 was a strong factor that predisposed patients to the development of SLE and LN, but did not influence kidney graft survival.

Cited by 16 publications

References 43 publications

Human leucocyte antigens profiling in Malay female patients with systemic lupus erythematosus: are we the same or different?

Human leucocyte antigens profiling in Malay female patients with systemic lupus erythematosus: are we the same or different?

Juvenile Systemic Lupus Erythematosus and hematological compromise

Association of atopic dermatitis with an increased risk of systemic lupus erythematosus

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