Association of atopic dermatitis with an increased risk of systemic lupus erythematosus

Ponvilawan, Ben; Charoenngam, Nipith; Wongtrakul, Wasit; Ungprasert, Patompong

doi:10.4103/jpgm.jpgm_1270_20

Cited by 10 publications

(3 citation statements)

References 53 publications

(73 reference statements)

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“…Moreover, systematic review and metaanalysis studies showed that patients with underlying allergic rhinitis, asthma and atopic dermatitis all increased the risk of developing SLE. 22,23,24 Our study demonstrated that allergic diseases and SLE can coexist which contradict the Th1 /Th2 paradigm mechanistic theory of autoimmune diseases and allergic diseases. More evidence shows that active SLE, a primarily autoantibody-mediated autoimmune diseases is indeed characterized by decreased function of Th1 25 and hyperfunction of Th2 26 .…”

Section: Discussionmentioning

confidence: 60%

Coexistence of allergic diseases in pediatric systemic lupus erythematosus patients: prevalence, clinical manifestation, severity and its association with disease activity

Suebsarakam,

kaweeyanont,

Srisutthika

et al. 2023

Preprint

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Background The prevalence of both allergic and autoimmune diseases is increasing, suggesting a potential association between these two disorders. Systemic lupus erythematosus (SLE) is a prototypical systemic autoimmune disease associated with multisystem organ involvement. This study aimed to investigate the prevalence, clinical manifestations and severity of allergic diseases in pediatric SLE patients and describe the association between severity of allergic diseases and SLE disease activity. Methods Pediatric SLE patients aged ≤ 18 years attending Khon Kaen University hospital, Thailand were enrolled during 2020–2022. Allergic diseases were screened using the International Study of Asthma and Allergies in Childhood questionnaire. SLE patients with a positive allergic disease screen were evaluated by a pediatric allergist for diagnostic confirmation using clinical criteria/testing. Correlation between SLE disease activity and the severity of allergic diseases was investigated using Spearman rank-order correlation coefficient. Results Out of 118 patients (median age 13.83 [11.71–15.90], 91.52% female),16 patients (13.56%) were confirmed to have one or more allergic diseases; fourteen with allergic rhinitis, four with asthma, and two with atopic dermatitis. Our study newly confirmed four patients with allergic rhinitis, one patient with atopic dermatitis and one patient with asthma. Two patients had severe-persistent allergic rhinitis and one newly diagnosed patient had uncontrolled severe asthma. No statistically significant correlations between the severity of allergic diseases and SLE disease activity were identified Conclusions The overall prevalence of allergic disease among pediatric SLE patients is 13.56% and is not less frequent than in the general population. Severe allergic diseases and SLE can coexist and allergies may be undiagnosed. Therefore, pediatric SLE patients should be assessed for coexisting allergic diseases. No correlations between the severity of allergic diseases and SLE disease activity were found.

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Section: Discussionmentioning

confidence: 60%

Coexistence of allergic diseases in pediatric systemic lupus erythematosus patients: prevalence, clinical manifestation, severity and its association with disease activity

Suebsarakam,

kaweeyanont,

Srisutthika

et al. 2023

Preprint

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“…Allergic disease of conjunctiva (including allergic conjunctivitis, atopic keratoconjunctivitis, vernal keratoconjunctivitis and giant papillary conjunctivitis) are rarely diagnosed in SLE patients. In the studies, people with SLE were shown to be at increased risk of IgE-related allergic disorders and atopic diseases in comparison with control groups [ 23 ].…”

Section: Ophthalmic Manifestations Of Slementioning

confidence: 99%

Understanding Ocular Findings and Manifestations of Systemic Lupus Erythematosus: Update Review of the Literature

Luboń

Kotyla

et al. 2022

IJMS

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Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease. Up to one-third of patients suffering from SLE have various ocular manifestations. The ocular findings may represent the initial manifestation of the systemic disease and may lead to severe ocular complications, and even loss of vision. Ocular manifestations are often associated with degree of systemic inflammation, but also can precede the occurrence of systemic symptoms. Early diagnosis and adequate management of patients with SLE are crucial and require cooperation between various specialists. Proper preparation of ophthalmologists can help to differentiate between complication of SLE and other ocular disorders. New therapies for SLE are promising for potential benefits, however, ocular side effects are still unknown.

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“…SLE patients with active disease were found to have an increased level of IgE, identical to people with allergic diseases. As a result, it is probable that enhanced Th2 activity and IgE production seen in allergic diseases could lead to the development of SLE later in life (Ponvilawan et al, 2021).…”

Section: Subjects Characteristicsmentioning

confidence: 99%

The Correlation between Allergic Diseases and Systemic Lupus Erythematosus

Pratiwi

Werdiningsih²,

Matea³

et al. 2022

INDONES J MED

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Background:The prevalence of autoimmune diseases and major chronic allergic diseases such as allergic rhinitis, asthma, and atopic dermatitis are increasing in line with the occurrence of climate change. Allergy and systemic lupus erythematosus (SLE) are sometimes being linked since both are immune diseases involving gene-environment interactions. The purpose of this research is to investigate the correlation between allergic diseases and SLE. Method: This case-control study was performed on 39 SLE subjects from the Tittari Community and 39 non-SLE subjects aged 15-49 years old, from September until October 2021. All of them were females. The independent variable was allergic disease and the dependent variable was SLE. Participants' characteristics and allergy data were collected through answering the online Score for Allergic Rhinitis (SFAR) questionnaire, then the results were processed with bivariate and multivariate analyses. Results:The correlation between allergic diseases and SLE was significant for atopic dermatitis but not for allergic rhinitis and asthma (p=0.018; p=0.352; p=0.151 respectively). The bivariate analysis revealed that the risk of SLE was 3.17 times higher in atopic dermatitis patients (OR=3.17; 95% CI=1.20-8.39; p=0.018). Furthermore, the multivariate analysis found that subjects with atopic dermatitis had the highest risk of SLE (OR= 3.18; 95% CI= 1.07-9.51; p=0.031). Conclusion: Among allergic diseases, atopic dermatitis was found to be significantly correlated with SLE, where the risk of SLE was raised as the number of atopic dermatitis increased.

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Association of atopic dermatitis with an increased risk of systemic lupus erythematosus

Cited by 10 publications

References 53 publications

Coexistence of allergic diseases in pediatric systemic lupus erythematosus patients: prevalence, clinical manifestation, severity and its association with disease activity

Coexistence of allergic diseases in pediatric systemic lupus erythematosus patients: prevalence, clinical manifestation, severity and its association with disease activity

Understanding Ocular Findings and Manifestations of Systemic Lupus Erythematosus: Update Review of the Literature

The Correlation between Allergic Diseases and Systemic Lupus Erythematosus

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