The prevalence of congenital cytomegalovirus infection in newborn infants at an intensive care unit in a public hospital

Miura, Clarissa Schreiner; Miura, Ernani; Mombach, Alice Beatriz; Chesky, Marisa

doi:10.2223/jped.1436

Cited by 7 publications

(5 citation statements)

References 24 publications

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“…Despite the recognized importance of congenital CMV infection in the world, only limited information is available about the incidence and natural history of this infection in Brazil [11, 12, 14, 15, 17]. In this population based newborn screening study, we found a 1.1% (95%CI: 0.86–1.33) birth prevalence of congenital CMV infection and 8.1% (95%CI: 3.3–15.9) of infected infants exhibited at least one clinical finding suggestive of congenital infection in the newborn period while 4.6% (CI95%:1.3–11.3) had multisystem CMV disease.…”

Section: Discussionmentioning

confidence: 99%

Birth Prevalence and Natural History of Congenital Cytomegalovirus Infection in a Highly Seroimmune Population

et al. 2009

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Background The natural history of congenital CMV infection is scarcely known in populations with high maternal CMV seroprevalence. This study evaluated birth prevalence, clinical findings at birth, and hearing outcome in infected children from such a population. Methods Infants consecutively born were screened for the presence of CMV in urine and/or saliva within the first two weeks. Neonatal clinical findings were recorded and infected children were tested to document hearing function during follow-up. A subset of mothers of infected infants was prenatally tested for the presence of anti-CMV IgG antibodies. Results Congenital CMV infection was confirmed in 87/8047 infants (1.08%; 95%CI: 0.86–1.33). Seven (8.1%; 95%CI: 3.3–15.9) infants had at least one clinical finding suggestive of CMV infection and 4 (4.6%; CI95%: 1.3–11.3) had ≥ 3 findings of systemic disease. Sensorineural hearing loss was found in 5/58 (8.6%; CI95%: 2.9–19.0) children tested at a median age of 21 months. Bilateral profound hearing loss was observed in two children and hearing threshold was >60 dBHL in all five children with hearing loss, including two children born to mothers with probable non primary CMV infection. Conclusions The results of this first large newborn screening study in a population with high CMV seroimmunity provide additional evidence that congenital CMV disease occurs in populations with high seroprevalence rates with a similar incidence of CMV-related hearing loss to that reported in offspring of women from populations in the developed countries with lower rates of seroimmunity to CMV.

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Section: Discussionmentioning

confidence: 99%

Birth Prevalence and Natural History of Congenital Cytomegalovirus Infection in a Highly Seroimmune Population

et al. 2009

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“…However, the infection rate was higher in comparison with Portugal (0.4%) and Belgium (0.5%) using viral isolation in cell cultures from urine samples 24,25 ; the USA (0.5%) using qPCR in saliva specimens targeting the glycoprotein B (gB) and the immediate early gene 2 (IE-2) exon 5 region 12 ; and with the sub-Saharan Africa (3.8%) using qPCR in saliva, serum and urine samples targeting the phosphoprotein pp65 (UL83) 26 . Lower prevalences have also been reported in previous studies conducted in Brazil: Sao Paulo (1%) (1980)(1981)(1982) using viral isolation in cell culture from urine samples and specific immunofluorescence anti-HCMV IgM in umbilical-cord serum 27 , Belo Horizonte (6.8%) (1995)(1996)(1997)(1998) and Porto Alegre (0.8%) (2003) using conventional PCR in urine samples 28,29 ; Ribeirao Preto (1%) (2003)(2004)(2005)(2006)(2007)(2008)(2009) and Ilheus (1.2%) (2010-2012) using conventional PCR in urine and/ or saliva samples 9,10 . This observed disagreement may be mostly associated with differences in the diagnostic methods and clinical samples 10,24 .…”

Section: Resultsmentioning

confidence: 54%

Frequency of congenital cytomegalovirus infections in newborns in the Sao Paulo State, 2010-2018

Figueiredo

Luchs

Durigon

et al. 2020

Rev. Inst. Med. trop. S. Paulo

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“…Jaundice, microcephaly, elevated liver enzyme levels, presence of intracranial calcification, intrauterine growth retardation were other findings. Preterm infants (< 32 weeks of gestation) with symptomatic congenital CMV are more likely to have pneumonitis, signs of viral sepsis, thrombocytopenia, and co-infections, and they are less likely to have microcephaly or intracranial calcifications compared to term neonates (2,4,13). In the case series of Ulubas Isik et al, 75% of the cases were preterm (12).…”

Section: Discussionmentioning

confidence: 99%

“…Although the importance of congenital CMV infection is obvious, the majority of maternal and fetal infections are not identified even in developed countries unless there is a screening program implemented. This may be due to the fact that only 10% of the infants with CMV infections manifest clinical symptoms (2,3). Furthermore, making a diagnosis of congenital/perinatal CMV infection is difficult because the sample from the infant collected on day 21 before birth should be negative and the sample collected from the same infant 21 days after birth should be positive in order to diagnose postnatal infection (4).…”

Section: Introductionmentioning

confidence: 99%

Congenital and Perinatal Cytomegalovirus Infections in the Neonatal Period: Case Series

Çiftdemir¹,

Acunaş²

2020

J Pediatr Inf

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Sitomegalovirüs enfeksiyonu hayatın ilk üç haftasında tanı aldığında genellikle konjenital ya da vertikal enfeksiyon düşündürürken, hayatın ilk üç haftasından sonra tanı alan sitomegalovirüs enfeksiyonları genellikle perinatal horizontal enfeksiyonlar olarak değerlendirilir. Hem konjenital hem de perinatal sitomegalovirüs enfeksiyonlarının tanısı ve tedavisi zor olduğundan, bu çalışmada yenidoğan yoğun bakım ünitesinde izlediğimiz olgu serisini sunarak konjenital/perinatal sitomegalovirüs enfeksiyonlarının tanısı ve tedavisindeki önemli noktaları vurgulamak istedik. Gereç ve Yöntemler: Üçüncü düzey yenidoğan yoğun bakım ünitesine Ağustos 2015-Mayıs 2018 tarihleri arasında konjenital/perinatal sitomegalovirüs enfeksiyonu nedeniyle yatan yenidoğanların tıbbi kayıtları retrospektif olarak değerlendirildi. Sadece sitomegalovirüs enfeksiyonuna yönelik spesifik tedavi alan bebekler çalışmaya dahil edildi. Bulgular: Çalışma sürecinde yenidoğan yoğun bakım ünitesine yatan 1039 bebekten 8 (%0.8)'i konjenital/perinatal sitomegalovirüs enfeksiyonu tanısıyla tedavi edildi. Tüm olgular preterm idi. Hayatın ilk 21 günü içinde CMV-DNA pozitif olduğu saptanan dört bebek konjenital sitomegalovirüs enfeksiyonu olarak tanı alırken diğer olgularda konjenital ve perinatal enfeksiyon ayrımı yapılamadı. Konjenital/perinatal enfeksiyonu olanlarda en sık görülen bulgular, anemi (%75), trombositopeni (%62.5) ve işitme kaybı (%62.5) idi. Hiçbir bebekte koryoretinit saptanmadı. Mikrosefalik 2 (%25) bebekte intrakraniyal kalsifikasyonlar

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The prevalence of congenital cytomegalovirus infection in newborn infants at an intensive care unit in a public hospital

Abstract: The prevalence of congenital cytomegalovirus infection in an intensive care unit at a public hospital in Porto Alegre was not considered elevated and was comparable with prevalence rates found by other studies.

Cited by 7 publications

References 24 publications

Birth Prevalence and Natural History of Congenital Cytomegalovirus Infection in a Highly Seroimmune Population

Birth Prevalence and Natural History of Congenital Cytomegalovirus Infection in a Highly Seroimmune Population

Frequency of congenital cytomegalovirus infections in newborns in the Sao Paulo State, 2010-2018

Congenital and Perinatal Cytomegalovirus Infections in the Neonatal Period: Case Series

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