The Prevalence of Age-Related Eye Disease in an Elderly Population

Hashemi, Hassan; Khabazkhoob, Mehdi; Nabovati, Payam; Ostadimoghaddam, Hadi; Shafaee, Shokrolah; Doostdar, Asgar; Yekta, Abbasali

doi:10.1080/09286586.2016.1270335

Cited by 33 publications

(19 citation statements)

References 29 publications

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“…Over the age of 75, this rate increases significantly to 8.7% and 13.5%. The anomalies characteristic of AMD were found in up to 90% of the examined subjects older than 90 years [3]. In addition, concomitant cardiovascular diseases are often associated with the same risk factors as the development of the abovementioned ocular diseases.…”

Section: Introductionmentioning

confidence: 99%

Age-related changes in retrobulbar circulation: a literature review

2019

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Introduction The advances in research methods used in ophthalmology allow for an increasingly accurate examination of the eyes, as well as the morphology and function of the vessels. Colour Doppler imaging is still the first-line method for the analysis of parameters of retrobulbar circulation. Therefore, the aim of this work was to present the current state of knowledge about anatomical and functional age-related changes in retrobulbar arteries. Methods A literature search was performed mainly based on the PubMed database. Results The anatomy of retrobulbar arteries, histological background of age-related vascular changes, age-related changes in retrobulbar blood flow in the ophthalmic artery, central retinal artery, short posterior ciliary arteries, and the reference values for the age-dependent retrobulbar circulation parameters measured by colour Doppler imaging are discussed in this review. Conclusion The age of the subject should always be taken into account when interpreting the parameters of retrobulbar blood flow measured by colour Doppler imaging.

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Section: Introductionmentioning

confidence: 99%

Age-related changes in retrobulbar circulation: a literature review

2019

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“…AMD is an epidemic multi-factorial disease with a prevalence of 8.7% in the world's population, and it has been estimated that by the year 2020, the number of affected people would be about 196 million 22 . According to a report, this figure for Iran is less than the global average (5.8%) 23 . Genome-wide studies have identified multiple genetic loci involved in AMD disease, and these have led to this fact that several important biological pathways, including the complement system, are important in the pathogenesis of the disease 24, 25.…”

Section: Discussionmentioning

confidence: 99%

The effect of complement factor B gene variation on age-related macular degeneration in Iranian patients

Roshanipour

Bonyadi

et al. 2019

Journal of Current Ophthalmology

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PurposeTo determine the possible association of rs4151667 (L9H) complement factor B (CFB) gene with age-related macular degeneration (AMD). The L9H is one of the functional variations of the CFB. CFB gene encodes the most important protein of the complement system.MethodsTwo hundred sixty-six patients with AMD and 194 unrelated age/sex-matched controls were genotyped for CFB gene (rs4151667) using the polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) method. All research subjects were selected from three regions of Iran (Tehran, Tabriz, and Gonabad).ResultsThe results showed a significant difference between the frequency of non-TT genotype in total patients and controls [odds ratio (OR) = 0.424, P = 0.038]. The analysis for each studied region showed that in patients originating from the Gonabad population, the frequency of TT and non-TT genotypes between patients and the control group were significantly different (OR = 2.894, P = 0.046 for TT genotype and OR = 0.346, P = 0.026 for non-TT genotype). In patients originating from Tabriz population, TT and non-TT genotypes and A allele revealed considerably different frequencies between the patient and control groups (OR = 3.043, P = 0.017; OR = 0.329, P = 0.013 and OR = 0.347, P = 0.048, respectively). Analysis of patients from Tehran also showed that there was a significant difference in the frequency of TT genotype between patients and controls (OR = 2.168, P = 0.04).ConclusionsThe results of the current study indicated a possible protective role for non-TT genotype in L9H variation CFB gene against AMD in a sample of the Iranian population. The region segregation results showed that TT genotype might be a risk factor for susceptibility to AMD.

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“…The system was specifically designed for handling by patients and not by health care professionals in order to allow automatic image acquisition in patients' homes or in nursing homes. This need is exacerbated by the mounting pressure to monitor a growing number of patients with chronic eye diseases 26 in an increasingly resource-constrained environment. 27 For example, in the United States, over 100 million people with chronic diseases account for about 75% of health care expenditures.…”

Section: Discussionmentioning

confidence: 99%

Safety and Feasibility of a Novel Sparse Optical Coherence Tomography Device for Patient-Delivered Retina Home Monitoring

Maloca

Hasler

Barthelmes

et al. 2018

Trans. Vis. Sci. Tech.

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PurposeTo study a novel and fast optical coherence tomography (OCT) device for home-based monitoring in age-related macular degeneration (AMD) in a small sample yielding sparse OCT (spOCT) data and to compare the device to a commercially available reference device.MethodsIn this prospective study, both eyes of 31 participants with AMD were included. The subjects underwent scanning with an OCT prototype and a spectral-domain OCT to compare the accuracy of the central retinal thickness (CRT) measurements.ResultsSixty-two eyes in 31 participants (21 females and 10 males) were included. The mean age was 79.6 years (age range, 69–92 years). The mean difference in the CRT measurements between the devices was 4.52 μm (SD ± 20.0 μm; range, −65.6 to 41.5 μm). The inter- and intrarater reliability coefficients of the OCT prototype were both >0.95. The laser power delivered was <0.54 mW for spOCT and <1.4 mW for SDOCT. No adverse events were reported, and the visual acuity before and after the measurements was stable.ConclusionThis study demonstrated the safety and feasibility of this home-based OCT monitoring under real-life conditions, and it provided evidence for the potential clinical benefit of the device.Translational RelevanceThe newly developed spOCT is a valid and readily available retina scanner. It could be applied as a portable self-measuring OCT system. Its use may facilitate the sustainable monitoring of chronic retinal diseases by providing easily accessible and continuous retinal monitoring.

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The Prevalence of Age-Related Eye Disease in an Elderly Population

Abstract: Overall, 35.8% of the studied population had at least one of the four diseases. Cataracts, followed by AMD, are the most common age-related eye diseases in the Iranian population, and thus, precise planning along with enhanced diagnostic and therapeutic facilities are necessary.

Cited by 33 publications

References 29 publications

Age-related changes in retrobulbar circulation: a literature review

Age-related changes in retrobulbar circulation: a literature review

The effect of complement factor B gene variation on age-related macular degeneration in Iranian patients

Safety and Feasibility of a Novel Sparse Optical Coherence Tomography Device for Patient-Delivered Retina Home Monitoring

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