The presentation of odontogenic keratocysts in the jaws with an emphasis on the tooth-bearing area: a systematic review and meta-analysis

Silva, Yuri Slusarenko da; Stoelinga, Paul J.W.; Naclério‐Homem, Maria da Graça

doi:10.1007/s10006-019-00754-5

Cited by 17 publications

(14 citation statements)

References 194 publications

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“…Odontogenic cysts and tumours could affect the maxilla and mandible to a great extent, leading to poor mechanical properties associated with perforated cortical bone in the mandible. 4 Posterior side of the mandible is observed to be more vulnerable to cysts and tumours as compared to other parts. 5–7 However, poor oral hygiene, unhealthy food habits, recurrence of cancers may severely affect the mandibular basal bone and can cause pathological failure.…”

Section: Introductionmentioning

confidence: 99%

Load transfer across a mandible during a mastication cycle: The effects of odontogenic tumour

Dutta

Mukherjee

Seesala

et al. 2020

Proc Inst Mech Eng H

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The extent to which load transfer in a diseased mandible with odontogenic tumour might influence the potential risk of pathological fracture has scarcely been investigated. The study sought to investigate the quantitative deviations in load transfer across healthy and cancer-affected (diseased) mandibles having odontogenic tumours. The effect of size of the tumours (small: 9 mm diameter, large: 19 mm diameter), and variation in bone mechanical (elastic) properties of the mandible on load transfer in cancer-affected mandibles during a mastication cycle have been investigated. Based on patient-specific computed tomography–scan datasets, detailed three-dimensional finite element models of healthy and diseased mandibles were developed. High stresses of 25–30 MPa and strains ∼700 µε were observed in the healthy mandible during the right molar bite. However, marginal deviations were observed in principal stress distributions in the diseased mandibles with small- and large-sized tumours, as compared to the healthy mandible. Maximum principal strains of ∼1474 µε were found in the body region adjacent to the symphysis region for small-sized tumour. Whereas for large-sized tumour, maximum strains of ∼2700 µε were observed in the right buccal regions. Reduction in Young’s modulus due to different stages of odontogenic tumours had a localised effect on the principal stress distributions, but triggered an abrupt increase in the principal tensile strains. It appears that there is a potential risk of pathological fracture for large-sized odontogenic tumour, owing to high tensile stresses and strains.

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Section: Introductionmentioning

confidence: 99%

Load transfer across a mandible during a mastication cycle: The effects of odontogenic tumour

Dutta

Mukherjee

Seesala

et al. 2020

Proc Inst Mech Eng H

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“…Neste relato de caso a paciente apresentava discreto abaulamento ósseo em região posterior de mandíbula esquerda, sinal clínico compatível com o que é encontrado na literatura. Radiograficamente os ceratocistos se apresentam como imagens radiolúcidas uni ou multiloculares com margens bem definidas, limitadas por bordas escleróticas 1,4,9,10 . Embora as imagens radiológicas desempenhem um papel de destaque no diagnóstico de ceratocistos, Borghesi et al 1 destacam que essas não são características patognomônicas, principalmente em lesões pequenas uniloculares, podendo simular outras lesões odontogênicas e não odontogênicas, como cisto radicular, cisto periodontal lateral ou cisto do ducto nasopalatino.…”

Section: Discussionunclassified

Tratamento cirúrgico do ceratocisto odontogênico por meio de enucleação e osteotomia periférica: relato de caso

Marques¹,

Barros²,

Teslenco³

et al. 2020

Arch Health Invest

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Introdução: Os ceratocistos odontogênicos (CCA) são considerados raros cistos de desenvolvimento, derivados dos remanescentes da lâmina dentária, com atividade intraóssea benigna, porém localmente invasivo e agressivo. O tratamento para o ceratocisto odongênico é variado, podendo-se encontrar modalidades tais como:enucleação, isolada ou associada a curetagem, com osteotomia periférica, aplicação da solução de Carnoy ou crioterapia, descompressão, marsupialização e ressecções. Objetivo: O presente trabalho tem como objetivo relatar um caso de ceratocisto odontogênico, onde foi escolhida abordagem conservadora por curetagem e osteotomia periférica. Relato de caso: Paciente de 68 anos, leucoderma, referiu ao exame clínico dor espontânea em região retromolar esquerda e parestesia em lábio inferior. A paciente foi submetida a biopsia por aspiração e excisional, após confirmação histopatológica foi proposto uma enucleação associada a osteotomia periférica sob anestesia geral. A paciente permanece em acompanhamento clínico e radiográfico, sem sinais de recidiva da lesão. Conclusão: Embora apresentem um comportamento agressivo, os ceratocistos odontogêncios podem ser tratados com segurança, de forma conservadora, por meio de enucleação seguida de osteotomia periférica com mínimo de morbidade. Descritores: Osteotomia; Curetagem; Cistos Odontogênicos. Referências Borghesi A, Nardi C, Giannitto C, Tironi A, Maroldi R, Di Bartolomeo F, Preda L. Odontogenic keratocyst: imaging features of a benign lesion with an aggressive behaviour. Insights Imaging. 2018 Oct;9(5):883-897. Park JH, Kwak EJ, You KS, Jung YS, Jung HD. Volume change pattern of decompression of mandibular odontogenic keratocyst. Maxillofac Plast Reconstr Surg. 2019 Jan 7;41(1):2. Karaca C, Dere KA, Er N, Aktas A, Tosun E, Koseoglu OT, Usubutun A. Recurrence rate of odontogenic keratocyst treated by enucleation and peripheral ostectomy: Retrospective case series with up to 12 years of follow-up. Med Oral Patol Oral Cir Bucal. 2018 Jul 1;23(4):e443-e448. Guerra LAP, Silva PS, Dos Santos RLO, Silva AMF, Albuquerque DP. Tratamento conservador de múltiplos tumores odontogênicos ceratocístico em paciente não sindrômico. Rev cir traumatol. buco-maxilo-fac. 2013; 13(2):43-50. Sundaragiri KS, Saxena S, Sankhla B, Bhargava A. Non syndromic synchronous multiple odontogenic keratocysts in a western Indian population: A series of four cases. J Clin Exp Dent. 2018;10(8):e831-6. Freitas AD, Veloso DA, Santos ALF, Freitas VA. Maxillary odontogenic keratocyst: a clinical case report. RGO Rev Gaúch Odontol. 2015; 63(4):484-88. Madhireddy MR, Prakash AJ, Mahanthi V, Chalapathi KV. Large Follicular Odontogenic Keratocyst affecting Maxillary Sinus mimicking Dentigerous Cyst in an 8-year-old Boy: A Case Report and Review. Int J Clin Pediatr Dent. 2018 Jul-Aug;11(4):349-351. Moura BS, Cavalcante MA, Hespanhol W. Tumor odontogênico ceratocistico. Rev Col Bras Cir., 2016;43(6):466-71. Valori FP, Costa E, Buscatti MY, Oliveira JX, Costa C. Tumor odontogênico queratocístico: características intrínsecas e elucidação da nova nomenclatura do queratocisto odontogênico. J Health Sci Inst. 2010;28(1):80-3. Slusarenko da Silva Y, Stoelinga PJW, Naclério-Homem MDG. The presentation of odontogenic keratocysts in the jaws with an emphasis on the tooth-bearing area: a systematic review and meta-analysis. Oral Maxillofac Surg. 2019;23(2):133-47.

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“…The maxilla was not considered in the present study because of its limited bone area that may result in a misleading diagnosis regarding the location of OKCs, that is, if they are located in the posterior or the tooth-bearing area. 1 Studies that met the inclusion criteria or those with doubtful information either in the title or abstract were selected for full-text assessment in a second round of this review. Reasons for rejection of studies were recorded for each report.…”

Section: Eligibility Criteriamentioning

confidence: 99%

“…A systematic review on the presentation of odontogenic keratocysts (OKCs) in the jaws, which included 2376 primary mandibular OKCs not related to the Nevoid Basal Cell Carcinoma Syndrome (NBCCS), has revealed that the difference in the clinical risk of having keratocysts in the posterior region of the mandible is of 21% (P < 0.02) as compared to the tooth-bearing area of the mandible 1 . In other words, patients have an estimated difference of 21% in the probability to have primary and nonsyndromic OKCs in the posterior region of the mandible.…”

Section: Introductionmentioning

confidence: 99%

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The presentation of recurrent odontogenic keratocysts of the mandible with an emphasis on the tooth‐bearing area: a systematic review and meta‐analysis

2020

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Aim: To gain insight in the actual ratio of recurrent odontogenic keratocysts (OKCs) occurring in the tooth-bearing area as compared to the posterior region of the mandible in order to come up with reliable data to base upon a rational treatment policy. Material and Methods: We searched MEDLINE, Web of Science, Scopus, Cochrane Library and Google Scholar databases for studies reporting on the location of recurrent mandibular OKCs. Risk Difference with a confidence interval of 95% of having the lesion in the tooth-bearing area versus the posterior region was the effect measure. P value for the summary effect of <0.05 was considered statistically significant. Results: The 1411 records retrieved were reduced to 13 studies to be qualitative/quantitative assessed. The pooled values showed that the difference in the clinical risk of having recurrent OKCs in the posterior region of the mandible and in the tooth-bearing area of the maxilla is of 7% (CI: À0.08, 0.22; P = 0.36), the posterior region being more susceptible to develop a recurrent OKC. Conclusions: The recurrence rate of OKCs in the posterior mandible is not significantly higher than of those located in the tooth-bearing part of the mandible; however, there is no reason to follow a more aggressive treatment policy for OKCs in the tooth-bearing area. Clinical RelevanceScientific rationale for study Once patients have an estimated difference of 21% to have primary keratocysts in the posterior mandible, it is important to gain insight into the actual ratio of recurrent keratocysts of the mandible. Principal findingsThe difference in the clinical risk of having recurrent keratocysts between the posterior region and toothbearing area of the mandible is 7%. Practical implicationsThe ratio of recurrent keratocysts in the posterior mandible is not significantly higher as compared to the tooth-bearing area. Therefore, there is no reason to follow a more aggressive treatment policy for keratocysts in the tooth-bearing area.

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The presentation of odontogenic keratocysts in the jaws with an emphasis on the tooth-bearing area: a systematic review and meta-analysis

Cited by 17 publications

References 194 publications

Load transfer across a mandible during a mastication cycle: The effects of odontogenic tumour

Load transfer across a mandible during a mastication cycle: The effects of odontogenic tumour

Tratamento cirúrgico do ceratocisto odontogênico por meio de enucleação e osteotomia periférica: relato de caso

The presentation of recurrent odontogenic keratocysts of the mandible with an emphasis on the tooth‐bearing area: a systematic review and meta‐analysis

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