The presence of ectopic atrial rhythm predicts adverse cardiovascular outcomes in a large hospital-based population

Huang, Sung‐Hao; Hu, Yu‐Feng; Chen, Pei-Fen; Lin, Yenn‐Jiang; Chang, Shih‐Lin; Lo, Li‐Wei; Tuan, Ta‐Chuan; Chao, Tze‐Fan; Liao, Jo‐Nan; Chang, Ting‐Yung; Lin, Chin‐Yu; Liu, Chih-Min; Huang, Ting-Chun; Lee, Po-Tseng; Lugtu, Isaiah C.; Jain, Ankit; Wu, I-Chien; Chen, Shih‐Ann

doi:10.1016/j.hrthm.2020.01.024

Cited by 5 publications

(7 citation statements)

References 13 publications

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“…There were signi cantly more premature atrial and ventricular beats in the T2D group at baseline. This is in accordance with previous studies on the topic and might be result of changes caused by both T2D itself, and the effects of common comorbidities like hypertension on the heart and autonomic nervous system 40,41 .…”

Section: Discussionsupporting

confidence: 93%

Acute effects of high intensity training on cardiac function - A pilot study comparing subjects with type 2 diabetes to healthy controls.

Ness

Ljones

Gjelsvik

et al. 2022

Preprint

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Purpose. The purpose of this study was to evaluate the acute stress on the heart following one session of high intensity interval training in patients with type 2 diabetes (T2D) versus healthy controls. Methods. High intensity aerobic exercise was performed by 4x4 minutes intervals (90-95% of maximal heart rate), followed by a ramp protocol to peak oxygen uptake (VO2peak). Echocardiography was performed before, and 30 minutes after exercise. Heart rhythm was monitored 24h pre-exercise, during and 24h post exercise by Holter electrocardiogram. Results. After exercise we report a reduction in in both groups in the early diastolic peak mitral annular velocity, the ratio of mitral peak early to late diastolic inflow. Further, left atrial end-systolic volume was reduced after exercise. The LV end-diastolic wall thickness increased in CG. T2D had significant more supraventricular extrasystoles per hour before and after exercise. Conclusion. One single session of exhaustive exercise induced acute cardiac alterations in both left- and right-sided cardiac chambers with reduction in volumes and indices of systolic and diastolic dysfunction in both T2D patients and controls. There was no indication of different stress response in T2D compared to controls. ClinicalTrials.gov Identifier: NCT02998008

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Section: Discussionsupporting

confidence: 93%

Acute effects of high intensity training on cardiac function - A pilot study comparing subjects with type 2 diabetes to healthy controls.

Ness

Ljones

Gjelsvik

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…There were significantly more premature SVES and VES in the T2D group at baseline, agreeing with previous related studies. That might result from changes caused by T2D and the effects of common comorbidities such as hypertension on the heart and autonomic nervous system 42 , 43 . There was no further effect of exercise on number of premature beats.…”

Section: Discussionmentioning

confidence: 99%

Acute effects of high intensity training on cardiac function: a pilot study comparing subjects with type 2 diabetes to healthy controls

Ness

Ljones

Gjelsvik

et al. 2022

Sci Rep

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This study evaluated acute cardiac stress after a high-intensity interval training session in patients with type 2 diabetes (T2D) versus healthy controls. High intensity aerobic exercise was performed by 4 × 4-min intervals (90–95% of maximal heart rate), followed by a ramp protocol to peak oxygen uptake. Echocardiography was performed before and 30 min after exercise. Holter electrocardiography monitored heart rhythms 24 h before, during, and 24 h after the exercise. Left atrial end-systolic volume, peak early diastolic mitral annular velocity, and the ratio of peak early to late diastolic mitral inflow velocity were reduced by approximately 18%, 15%, and 31%, respectively, after exercise across groups. Left ventricular end-diastolic wall thickness was the only echo parameter that significantly differed between groups in response to exercise. The T2D group had a rate of supraventricular extrasystoles per hour that was 265% greater than that of the controls before exercise, which remained higher after exercise. A single exhaustive exercise session impaired left ventricular diastolic function in both groups. The findings also indicated impaired right ventricular function in patients with T2D after exercise.ClinicalTrials.gov Identifier: NCT02998008.

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“…PAC burden in a population with chronic autonomic failure is associated with decreased sympathetic and parasympathetic activity ( Goldstein, 2010 ). In a large cohort study, PAC burden was associated with both ANS imbalance and decreased global activity ( Huang et al, 2020 ). ANS abnormalities seem to be involved in PAC physiopathology through structural remodeling.…”

Section: Physiopathology and Epidemiology Of Nonsustained Atrial Arrh...mentioning

confidence: 99%

“…Three recent meta-analyses assessed the association between PACs, morbidity, and mortality ( Himmelreich et al, 2019 ; Huang et al, 2020 ; Meng et al, 2020 ). The presence of a significant PAC burden is associated with a 3-fold increase in AF occurrence and is independently associated with a 2-fold increase.…”

Section: Physiopathology and Epidemiology Of Nonsustained Atrial Arrh...mentioning

confidence: 99%

“…Both premature atrial contractions (PACs) and nonsustained atrial firing are frequent conditions. Historically considered a benign phenomenon, challenging data have highlighted its impact on morbidity and mortality, whether in terms of atrial fibrillation (AF), ischemic stroke or all-cause and cardiovascular mortality ( Himmelreich et al, 2019 ; Huang et al, 2020 ; Meng et al, 2020 ). However, the diagnostic and therapeutic management of ectopic atrial rhythm is not yet precisely standardized ( Farinha et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

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Premature atrial contractions: A predictor of atrial fibrillation and a relevant marker of atrial cardiomyopathy

Guichard

Guasch²,

Roche³

et al. 2022

Front. Physiol.

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An increased burden of premature atrial contractions (PACs) has long been considered a benign phenomenon. However, strong evidence of their involvement in the occurrence of atrial fibrillation (AF), ischemic stroke, and excess mortality suggests the need for management. The central question to be resolved is whether increased ectopic atrial rhythm is only a predictor of AF or whether it is a marker of atrial cardiomyopathy and therefore of ischemic stroke. After reviewing the pathophysiology of PACs and its impact on patient prognosis, this mini-review proposes to 1) detail the physiological and clinical elements linking PACs and AF, 2) present the evidence in favor of supraventricular ectopic activity as a marker of cardiomyopathy, and 3) outline the current limitations of this concept and the potential future clinical implications.

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The presence of ectopic atrial rhythm predicts adverse cardiovascular outcomes in a large hospital-based population

Cited by 5 publications

References 13 publications

Acute effects of high intensity training on cardiac function - A pilot study comparing subjects with type 2 diabetes to healthy controls.

Acute effects of high intensity training on cardiac function - A pilot study comparing subjects with type 2 diabetes to healthy controls.

Acute effects of high intensity training on cardiac function: a pilot study comparing subjects with type 2 diabetes to healthy controls

Premature atrial contractions: A predictor of atrial fibrillation and a relevant marker of atrial cardiomyopathy

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