This study evaluated acute cardiac stress after a high-intensity interval training session in patients with type 2 diabetes (T2D) versus healthy controls. High intensity aerobic exercise was performed by 4 × 4-min intervals (90–95% of maximal heart rate), followed by a ramp protocol to peak oxygen uptake. Echocardiography was performed before and 30 min after exercise. Holter electrocardiography monitored heart rhythms 24 h before, during, and 24 h after the exercise. Left atrial end-systolic volume, peak early diastolic mitral annular velocity, and the ratio of peak early to late diastolic mitral inflow velocity were reduced by approximately 18%, 15%, and 31%, respectively, after exercise across groups. Left ventricular end-diastolic wall thickness was the only echo parameter that significantly differed between groups in response to exercise. The T2D group had a rate of supraventricular extrasystoles per hour that was 265% greater than that of the controls before exercise, which remained higher after exercise. A single exhaustive exercise session impaired left ventricular diastolic function in both groups. The findings also indicated impaired right ventricular function in patients with T2D after exercise.ClinicalTrials.gov Identifier: NCT02998008.
Purpose. The purpose of this study was to evaluate the acute stress on the heart following one session of high intensity interval training in patients with type 2 diabetes (T2D) versus healthy controls. Methods. High intensity aerobic exercise was performed by 4x4 minutes intervals (90-95% of maximal heart rate), followed by a ramp protocol to peak oxygen uptake (VO2peak). Echocardiography was performed before, and 30 minutes after exercise. Heart rhythm was monitored 24h pre-exercise, during and 24h post exercise by Holter electrocardiogram. Results. After exercise we report a reduction in in both groups in the early diastolic peak mitral annular velocity, the ratio of mitral peak early to late diastolic inflow. Further, left atrial end-systolic volume was reduced after exercise. The LV end-diastolic wall thickness increased in CG. T2D had significant more supraventricular extrasystoles per hour before and after exercise. Conclusion. One single session of exhaustive exercise induced acute cardiac alterations in both left- and right-sided cardiac chambers with reduction in volumes and indices of systolic and diastolic dysfunction in both T2D patients and controls. There was no indication of different stress response in T2D compared to controls. ClinicalTrials.gov Identifier: NCT02998008
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