A dose of MVPA below current recommendations reduced mortality by 22% in older adults. A further increase in physical activity dose improved these benefits in a linear fashion. Older adults should be encouraged to include even low doses of MVPA in their daily lives.

Background-Enhanced nocturnal heart rate variability (HRV) has been evoked in sleep-related breathing disorders. However, its capacity to detect obstructive sleep apnea syndrome (OSAS) has not been systematically determined. Thus, we evaluated the discriminant power of HRV parameters in a first group of patients (G1) and validated their discriminant capacity in a second group (G2

Performance is correlated with nocturnal ANS activity at an individual level. The decrease in ANS activity during intensive training is correlated with the loss in performance, and the rebound in ANS activity during tapering tracks with the gain in performance. Interestingly, the speed of the rebound during the tapering period was quite different between swimmers. ANS activity measurement may be useful to design and control individual training periods and to optimize the duration of tapering.

No abstract

NCT 00759304 and NCT 00766584.

The %VLFI and LF/HF ratio provide indirect measures of sleep fragmentation, suggesting that HRV measures during sleep assess more the associated sleep fragmentation than the presence of a specific sleep disorder.

ClinicalTrials.gov identifiers NCT 00759304 and NCT 00766584.

The obstructive sleep apnea component intermittent hypoxia (IH) causes low-grade neuroinflammation in the dorsal hippocampus of mice, including early but transient cytokine elevations, delayed but long-term microglial changes, and cytokine response alterations to lipopolysaccharide inflammatory challenge. These changes may contribute to IH-induced cognitive impairment and pathological brain aging.