‘The presence of blood in the transfer catheter negatively influences outcome at embryo transfer’

Marikinti, Karunakar; Brinsden, Peter

doi:10.1093/humrep/deh812

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…Indeed, the destructive actions of uterine motility are prevented from the transfer sperm and even embryo into the uterus. The origin of the uterine contractions is related to junctional zone in the myometrium layer [10,11].…”

Section: Discussionmentioning

confidence: 99%

The effect of administrating hyoscine bromide on pregnancy rate before embryo transfer in ART cycles

Zargar¹,

Kajbaf²,

Hemadi³

2013

OJOG

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Assisted reproductive technology methods i.e., IVF and ICSI were extensively used for treatment of infertility. Although, these methods have many advantages but ART pregnancy rate remains low (30%-35%). It seems that uterine peristalsis occurred after rhCG administration in turn resulting to impair implantation of the transferred embryos. Therefore this study was conducted to possess of whether hyoscine bromide can effectively alleviate uterine contraction and then have any effect on the reproductive outcome. Healthy women who underwent IVF or ICSI cycles (n = 142) were randomly assigned to one of two groups at the start of the cycle. Group control (n = 71) without applied hyoscine and group experiment (n = 71) applied hyoscine (25 mg). Controlled ovarian hyperstimulation was induced with follicle stimulating hormone (FSH). Sperm preparation and ovarian puncture for in vitro maturation and fertilization (IVF) of oocyte were carried out for 42 hours after rhCG injection. Two weeks after rhCG injection, bhCG pregnancy test to determine pregnancy outcome in both groups was done and the outcome results, along with other information were recorded separately. The pregnancy rate in experimental group was significantly higher than that of control group. when all of the cycles with or without giving 25 mg of hyosine were stratified by the mean total follicles (more/less than 2 follicles) and embryos (more/less than 25 kg/m 2), the Patients' age, the quality grade of embryos and infertility duration (more/less than 5 years), the reproductive outcome, in overall, in the subjects with more than 10 oocytes, 5 embryos, more than quality A and B grades of embryos, less than 35 years age and also less than 5 years infertility duration was more pronounced than the other patients. But the other parameter was not affected by the reproductive outcome. Clinical or statistical improvement of the reproductive outcome could be demonstrated in the hyosine treated group especially with increasing the mean total follicles, embryo, quality of embryo in women with low age and infertility duration. However, further well-designed studies are essential to offer a final conclusion.

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Section: Discussionmentioning

confidence: 99%

The effect of administrating hyoscine bromide on pregnancy rate before embryo transfer in ART cycles

Zargar¹,

Kajbaf²,

Hemadi³

2013

OJOG

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“…In such situations, cervical manipulation using a cotton swab may lead to mechanical injury and a bloody discharge. During ET, blood from the endocervix may be drawn into the uterus and interfere with embryo implantation 17,18 . However, Moragianni et al.…”

Section: Discussionmentioning

confidence: 99%

Improvement in pregnancy rate by removal of cervical discharge prior to embryo transfer in ICSI cycles: A randomised clinical trial

Moini

Kiani

Bahmanabadi

et al. 2011

Australian and New Zealand Journal of Obstetrics and Gynaecology

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Difficult embryo transfer (ET) components and cycle outcome. Which is more harmful?

Ghanem

Alboghdady

Helal

et al. 2016

Middle East Fertility Society Journal

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‘The presence of blood in the transfer catheter negatively influences outcome at embryo transfer’

Cited by 4 publications

References 6 publications

The effect of administrating hyoscine bromide on pregnancy rate before embryo transfer in ART cycles

The effect of administrating hyoscine bromide on pregnancy rate before embryo transfer in ART cycles

Improvement in pregnancy rate by removal of cervical discharge prior to embryo transfer in ICSI cycles: A randomised clinical trial

Difficult embryo transfer (ET) components and cycle outcome. Which is more harmful?

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