Difficult embryo transfer (ET) components and cycle outcome. Which is more harmful?

Ghanem, M.; Alboghdady, Laila A.; Helal, Ahmed H.; Bedairy, M.H.; Bahlol, Ibrahiem; Abdelaziz, Ayman Ahmed

doi:10.1016/j.mefs.2015.10.004

Cited by 7 publications

(11 citation statements)

References 25 publications

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“…When difficulties in ET were analyzed individually, the authors found significant association with reduced clinical pregnancy rate only with blood on tip of the catheter and cervical sounding. Neither cervical traction nor blood on outer sheath was associated with reduced clinical pregnancy rate (8) .…”

Section: Discussionmentioning

confidence: 88%

“…The different impact of various difficulty categories shown by the study conducted by Ghanem (8) emphasizes this fact: difficult ET is a very heterogeneous spectrum.…”

Section: Discussionmentioning

confidence: 95%

“…ET procedure is easy in most cases. In a quarter of cases, however, a difficult ET procedure is encountered (8) . Difficulties in ET procedure are often caused by a stenosed cervical os, tortuous cervical canal and extreme utero-cervical angle (8) .…”

Section: Discussionmentioning

confidence: 99%

“…In another retrospective analysis conducted by Ghamen (8) between June 2013 and May 2015, at two centers: Mansoura University Infertility Center and a private center, 744 ET procedures were analyzed. Difficult ET was defined, in this study, when cervical traction was needed, blood was encountered on outer sheath, blood was encountered on tip of the catheter, and when cervical sounding was needed.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, for a small group of women, ET procedure remains difficult and requires further steps, which may induce uterine contractions or provoke endocervical or endometrial bleeding; which both might have an adverse impact on successful implantation and the whole IVF outcome (5) . More interestingly, several prospective and retrospective studies have observed that even women who had successful implantation following difficult ETs might have remote bad outcome, in terms of miscarriage (1,4,7,8,9) . In addition to the evident association between difficult ET and negative pregnancy outcome, an association between difficult ET and first trimester miscarriage, among women who had initially a positive clinical pregnancy outcome, has been practically and clinically observed (unpublished observational study).…”

Section: Introductionmentioning

confidence: 99%

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Pregnancy Outcome after Difficult Embryo Transfer in IVF-ET Cycles

Mahmod

Fayed²,

El-Din³

et al. 2018

Egyptian Journal of Hospital Medicine

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Background: Embryo transfer (ET) is one of the most crucial steps in IVF/ICSI treatment. Although it, apparently, seems simple, it is an integral part of IVF/ICSI and can affect the outcome of the whole treatment cycle. The majority of couples (approximately 80%) who undergo IVF reach the ET stage, yet few pregnancies occur. The pregnancy rate after ET is dependent on multiple factors including embryo quality, endometrial receptivity, and the technique of the ET. Aim of the Work: The aim of the current study is to investigate the clinical and ongoing clinical pregnancy rates in women who experience difficult embryo transfer (ET) after IVF/ICSI cycle. Patients and Methods: This prospective cohort study was conducted at Dar Al-Teb Infertility and IVF Center between January 2017 and January 2018. The study included 417 women planned to undergo ET. Results: The biochemical, clinical and ongoing clinical pregnancy rates were significantly lower in women who had difficult ET when compared to women who had easy ET [ORs 0.5, 95% CI (0.31 to 0.83); 0.48, 95% CI (0.29 to 0.79); 0.36, 95% CI (0.21 to 0.62); respectively]. Conclusion: Difficult ET is associated with significantly reduced biochemical, clinical and ongoing clinical pregnancy rates. Recommendations: ET should be smooth with easy passage of the transfer catheter. Since any uterine manipulation during ET adversely affects IVF results, therefore precaution should be taken to identify possibly difficult ET cases in advance.

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Section: Discussionmentioning

confidence: 88%

“…The different impact of various difficulty categories shown by the study conducted by Ghanem (8) emphasizes this fact: difficult ET is a very heterogeneous spectrum.…”

Section: Discussionmentioning

confidence: 95%