The preparation of thioureas and thiuram‐disulphides

Abstract

A standardized method, markedly efficient, for the preparation of symmetrically substituted thioureas and thiuram disulphides from primary and secondary amines has been developed in conformity with the following equations: Its uniformity of application to seven primary amines and to seven secondary amines has made possible a comparative study of the times required, the extent of completion of the reactions, and the effect of various substituents, in the preparation of the corresponding thioureas and thiuram‐disulphides. The preparation and identification by quantitative analysis of five thioureas and five thiuram disulphides, not previously recorded in the literature, has been effected. Three new unsymmetrical tri‐substituted thioureas have been prepared in conformity with the general equation, RNCS+R′R″NH → RNH. CS. NR′R″. Their identity has been established by quantitative analyses.