The Preparation of Palladium Nanoparticles

Cookson, James

doi:10.1595/147106712x632415

Cited by 181 publications

(95 citation statements)

References 109 publications

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“…19 Recently, several inorganic NPs, including silver, palladium (Pd), and gold, have been used as anticancer agents in various types of cancer cells. [20][21][22] Generally, studies that applied palladium nanoparticles (PdNPs) were mainly interested in hydrogen storage and sensing, 23 catalysis, 24 hydrogenation, 25 oxidation, 26 carbon-carbon bond formation, 27 and fuel cells, 28 but not cancer. Studies on the anticancer effects of PdNPs are very limited, and so far, there has been no report about the combinatorial effect of TUB-A and PdNPs on human breast cancer cells.…”

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confidence: 99%

Combination of palladium nanoparticles and tubastatin-A potentiates apoptosis in human breast cancer cells: a novel therapeutic approach for cancer

Yuan¹,

Peng²,

Gurunathan³

2017

IJN

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Background Breast cancer is the most common malignant disease that occurs in women. Histone deacetylase (HDAC) inhibition has recently emerged as an effective and attractive target for the treatment of cancer. The aim of this study was to investigate the efficacy of a combined treatment of tubastatin A (TUB-A) and palladium nanoparticles (PdNPs) against MDA-MB-231 human breast cancer cells using two different cytotoxic agents that work by two different mechanisms, thereby decreasing the probability of chemoresistance in cancer cells and increasing the efficacy of toxicity, to provide efficient therapy for advanced stage of cancer without any undesired side effects. Methods PdNPs were synthesized using a novel biomolecule called R-phycoerythrin and characterized using various analytical techniques. The combinatorial effect of TUB-A and PdNPs was assessed by various cellular and biochemical assays and also by gene expression analysis. Results The biologically synthesized PdNPs had an average size of 25 nm and were spherical in shape. Treatment of MDA-MB-231 human breast cancer cells with TUB-A or PdNPs showed a dose-dependent effect on cell viability. The combination of 4 μM TUB-A and 4 μM PdNPs had a significant inhibitory effect on cell viability compared with either TUB-A or PdNPs alone. The combinatorial treatment also had a more pronounced effect on the inhibition of HDAC activity and enhanced apoptosis by regulating various cellular and biochemical changes. Conclusion Our results suggest that there was a strong synergistic interaction between TUB-A and PdNPs in increasing apoptosis in human breast cancer cells. These data provide an important preclinical basis for future clinical trials on this drug combination. This combinatorial treatment increased therapeutic potentials, thereby demonstrating a relevant targeted therapy for breast cancer. Furthermore, we have provided the first evidence for the combinatorial effect and mechanism of toxicity of TUB-A and PdNPs in human breast cancer cells. The novelties of the study were identification of a combination therapy that consists of suitable therapeutic molecules that kill cancer cells and also exploration of two different possible mechanisms involved to reduce chemoresistance in cancer cells.

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confidence: 99%

Combination of palladium nanoparticles and tubastatin-A potentiates apoptosis in human breast cancer cells: a novel therapeutic approach for cancer

Yuan¹,

Peng²,

Gurunathan³

2017

IJN

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“…Among noble metal nanoparticles, palladium NPs are particularly efficient in catalysis and they have been heavily studied in a wide range of applications including hydrogenations, oxidations, carbon-carbon bond formation, and electrochemical reactions in fuel cells [61]. In the following examples, the catalytic behavior of Pd NPs immobilized on zirconium phosphates and phosphonates are reported.…”

Section: Catalytic Reaction Referencementioning

confidence: 99%

Zirconium Phosphate Catalysts in the XXI Century: State of the Art from 2010 to Date

Pica

2017

Catalysts

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An overview on the developments of zirconium phosphate (ZrP) and its organic derivatives in heterogeneous catalysis in recent years is reported in the present review. Two basic aspects have been emphasized: first, the catalytic properties of zirconium phosphates were discussed, with particular attention to the effect of surface acidity and hydrophobic/hydrophilic character, textural properties, and particle morphology on the catalytic performances. Then, the use of zirconium phosphates as support for catalytic active species was reported, including organometallic complexes, metal ions, noble metal, and metal oxide nanoparticles. Zirconium phosphate plays, in those cases, a dual role, since it promotes the dispersion and stabilization of the catalysts, thanks to their interaction with the active sites on the surface of ZrP, and facilitates the recovery and reuse of the catalytic species due to their immobilization on the solid support.

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“…In order to synthesize noble nanometals, various methods have been established, including a polyol process, sodium borohydride (NaBH4) reduction, and photoreduction [6][7][8][9][10][11][12]. Nevertheless, these conventional synthesis methods have several disadvantages, including the use of noxious reagents and volatile organic solvents as well as the production of hazardous by-products [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Expeditious Synthesis of Noble Metal Nanoparticles Using Vitamin B12 under Microwave Irradiation

et al. 2015

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A greener synthesis protocol for noble nanometals is developed using vitamin B12 as a reducing and capping agent in conjunction with the use of microwaves. Successful assembly of nanoparticles or microparticles with varied shapes and sizes have been demonstrated. The synthesized Ag, Au, and Pd samples were thoroughly characterized with X-ray diffraction, scanning electron microscopy, transmission electron microscopy, high resolution transmission microscopy, and UV-visible spectrophotometry, confirming that metallic Ag, Au, and Pd were synthesized by the green chemistry method.

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The Preparation of Palladium Nanoparticles

Cited by 181 publications

References 109 publications

Combination of palladium nanoparticles and tubastatin-A potentiates apoptosis in human breast cancer cells: a novel therapeutic approach for cancer

Combination of palladium nanoparticles and tubastatin-A potentiates apoptosis in human breast cancer cells: a novel therapeutic approach for cancer

Zirconium Phosphate Catalysts in the XXI Century: State of the Art from 2010 to Date

Expeditious Synthesis of Noble Metal Nanoparticles Using Vitamin B12 under Microwave Irradiation

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