The pre- and postnatal development of the dopaminergic cell groups in the ventral mesencephalon and the dopaminergic innervation of the striatum of the rat

Voorn, Pieter; Kalsbeek, Andries; Jorritsma‐Byham, Barbara; Groenewegen, H.J.

doi:10.1016/0306-4522(88)90041-3

Cited by 479 publications

(287 citation statements)

References 49 publications

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“…Each of these receptor families has not only a distinct localization pattern within the CNS but also intracellular signaling pathways, which allow dopamine to exert numerous diverse effects on the cells to which they project. Early in the embryonic period, dopamine 17,18 and its receptors 19,20 are present in the highly proliferative germinal zones of the brain, supporting the hypothesis that dopamine plays a role in neurogenesis during brain development. 20 Dopamine arrives in the forebrain via the nigrostriatal pathway at around embryonic day 13 in the mouse, a timepoint at which tyrosine hydroxylase fibres approach the lateral ventricular border and lie in very close proximity to the proliferating progenitor cells.…”

Section: Dopaminergic Control Of Neurogenesismentioning

confidence: 61%

Dopaminergic modulation of neurogenesis in the subventricular zone of the adult brain

O’Keeffe¹,

Barker²,

Caldwell³

2009

Cell Cycle

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Section: Dopaminergic Control Of Neurogenesismentioning

confidence: 61%

Dopaminergic modulation of neurogenesis in the subventricular zone of the adult brain

O’Keeffe¹,

Barker²,

Caldwell³

2009

Cell Cycle

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“…Migration of the dopaminergic neurons to their final positions in the ventral mesencephalon and innervation in their target sites occur during the first postnatal weeks. In rats, this phase of dopaminergic neuronal development appears to be completed around the third postnatal week (Voorn et al, 1988). At this time, the morphology and functionality of the dopaminergic system are identical to that observed in adults.…”

Section: Development Of Dopaminergic Neuronsmentioning

confidence: 72%

Effects of Prenatal and Neonatal Exposure to Bisphenol A on the Development of the Central Nervous System

Mizuo¹,

Narita²,

Miyagawa³

et al. 2010

Biomolecules and Therapeutics

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-Bisphenol A (BPA) is one of the most common endocrine disrupters. In the last decade, the number of studies concerning the effects of chronic treatment with BPA on the development of the central nervous system (CNS) has increased. However, little is known about the effects of chronic exposure to BPA on higher brain functions such as memory or psychomotor functions. Here, we report our following findings: (1) Prenatal and neonatal exposure to BPA enhances psychostimulant-induced rewarding effects, results in the up-or downregulation of dopamine receptors, causes memory impairment, and decreases choline acetyltransferase (ChAT) activity. (2) BPA activates astrocytes in vivo and in vitro. These findings suggest that prenatal and neonatal exposure to BPA affects the development of the CNS.

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“…The development of midbrain DA neurons provides a good model system for the investigation of molecular mechanisms underlying the determination of specific neuronal fates and axonal guidance pathways. During embryonic development, the midbrain DA neurons appear in the intermediate zone of the ventral neural tube and extend their fibers en masse to target regions, including the striatum, through selective axonal pathways (3,4). Recent studies have identified several factors involved in the development of DA neurons (5).…”

mentioning

confidence: 99%

Visualization, direct isolation, and transplantation of midbrain dopaminergic neurons

Sawamoto

Nakao

Kobayashi

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

219

209

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To visualize and isolate live dopamine (DA)-producing neurons in the embryonic ventral mesencephalon, we generated transgenic mice expressing green fluorescent protein (GFP) under the control of the rat tyrosine hydroxylase gene promoter. In the transgenic mice, GFP expression was observed in the developing DA neurons containing tyrosine hydroxylase. The outgrowth and cue-dependent guidance of GFP-labeled axons was monitored in vitro with brain culture systems. To isolate DA neurons expressing GFP from brain tissue, cells with GFP fluorescence were sorted by fluorescence-activated cell sorting. More than 60% of the sorted GFP ؉ cells were positive for tyrosine hydroxylase, confirming that the population had been successfully enriched with DA neurons. The sorted GFP ؉ cells were transplanted into a rat model of Parkinson's disease. Some of these cells survived and innervated the host striatum, resulting in a recovery from Parkinsonian behavioral defects. This strategy for isolating an enriched population of DA neurons should be useful for cellular and molecular studies of these neurons and for clinical applications in the treatment of Parkinson's disease.

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The pre- and postnatal development of the dopaminergic cell groups in the ventral mesencephalon and the dopaminergic innervation of the striatum of the rat

Cited by 479 publications

References 49 publications

Dopaminergic modulation of neurogenesis in the subventricular zone of the adult brain

Dopaminergic modulation of neurogenesis in the subventricular zone of the adult brain

Effects of Prenatal and Neonatal Exposure to Bisphenol A on the Development of the Central Nervous System

Visualization, direct isolation, and transplantation of midbrain dopaminergic neurons

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