Effects of Prenatal and Neonatal Exposure to Bisphenol A on the Development of the Central Nervous System

Abstract

-Bisphenol A (BPA) is one of the most common endocrine disrupters. In the last decade, the number of studies concerning the effects of chronic treatment with BPA on the development of the central nervous system (CNS) has increased. However, little is known about the effects of chronic exposure to BPA on higher brain functions such as memory or psychomotor functions. Here, we report our following findings: (1) Prenatal and neonatal exposure to BPA enhances psychostimulant-induced rewarding effects, results in the up-or downregulation of dopamine receptors, causes memory impairment, and decreases choline acetyltransferase (ChAT) activity. (2) BPA activates astrocytes in vivo and in vitro. These findings suggest that prenatal and neonatal exposure to BPA affects the development of the CNS.

Bisphenol A depresses monosynaptic and polysynaptic reflexes in neonatal rat spinal cord in vitro involving estrogen receptor-dependent NO-mediated mechanisms

“…Besides classic ER pathways, increasing evidences show that BPA also triggers nonclassical (non-genomic) estrogen-activated pathways via extra-nuclear ERs (Wozniak et al, 2005;AlonsoMagdalena et al, 2008). Further, the involvement of G protein-coupled responses (GPCR) in rapid signaling of BPA for mediating behavior and memory of rats has been reported (Mizuo et al, 2010). The rapidity of the depressant action of BPA in this study supports for the extranuclear non-genomic pathways for the BPA-mediated actions.…”

Differential effects of bisphenol A toxicity on oyster (Crassostrea angulata) gonads as revealed by label-free quantitative proteomics

“…BPA has also been observed inducing changes in invertebrates: abnormal reproductive cells, organs, and imposex have been detected in freshwater snails, while superfemales and feminization have been reported in females of the freshwater prosobranch, Marisa cornuarietis (Oehlmann et al, 2000;Kang et al, 2007). Another adverse endocrine-disrupting effect in aquatic organisms is the inhibition of gonadal growth, which adversely affects the central nervous system and immune system (Sohoni et al, 2001;Mizuo et al, 2010;Nakamura and Kariyazono, 2010). However, the mechanisms involved are not known for certain (Crain et al, 2007).…”

Application of Molecular Imprinted Polymers for Selective Solid Phase Extraction of Bisphenol A

“…In this case, incomplete conversion of monomers during the polymerization process can leach out of the bisphenol A, from such materials into the environment, especially during heating of the cans or contact with basic or acidic substances [22,23]. It seems that bisphenol A can easily get into the environment, widely exist there and finally migrate into the human body to produce adverse effects on health [24]. Therefore the monitoring of these endocrine disrupting chemicals should be of immense importance.…”