Dopaminergic modulation of neurogenesis in the subventricular zone of the adult brain

O’Keeffe, Gráinne C.; Barker, Roger A.; Caldwell, Maeve A.

doi:10.4161/cc.8.18.9512

Cited by 86 publications

(74 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In order to better understand survival and fate of these cells following dopamine depletion, we analyzed the NPC in the OB, using BrdU labeling. In line with other investigators, the number of surviving BrdU+ NPC in PGL and GCL decreased after a 6-OHDA lesion (O'Keeffe et al, 2009a;O'Keeffe et al, 2009b). This may readily be explained by the evident downregulation of NPC proliferation in the SVZ.…”

Section: Histological Studysupporting

confidence: 90%

See 1 more Smart Citation

3.146 Modulation of Adult Neurogenesis in the Olfactory Bulb in an Acute Mouse Model of Parkinson's Disease

Chiu¹,

Carlsson²,

Arend³

et al. 2012

Parkinsonism & Related Disorders

View full text Add to dashboard Cite

Section: Histological Studysupporting

confidence: 90%

“…Also, a species related regulation was reported for D3 receptors (Baker et al, 2005). The administration of L-DOPA and DA agonists reversed the downregulation caused by DA depletion in the nigrostriatal pathway (O'Keeffe et al, 2009a;O'Keeffe et al, 2009b). …”

Section: Dopaminergic Controlmentioning

confidence: 80%

3.146 Modulation of Adult Neurogenesis in the Olfactory Bulb in an Acute Mouse Model of Parkinson's Disease

Chiu¹,

Carlsson²,

Arend³

et al. 2012

Parkinsonism & Related Disorders

View full text Add to dashboard Cite

“…Dopaminergic projections from the SNc into the adult subventricular zone (SVZ) exist, where primary neural precursor cells express dopamine receptors [17,22,27,57]. Administration of dopamine receptor agonists restores these deficits in the SVZ and olfactory bulb [22,25,27,39]. However, the functional relevance of these newborn olfactory bulb interneurons remains to be fully understood [30], and the dopaminergic stimulation of neurogenesis is not unequivocally accepted [5,7].…”

Section: Electronic Supplementary Materialsmentioning

confidence: 96%

A new dopaminergic nigro-olfactory projection

Höglinger¹,

Alvarez‐Fischer

Arias-Carrión³

et al. 2015

Acta Neuropathol

View full text Add to dashboard Cite

Parkinson disease (PD) is a neurodegenerative disorder characterized by massive loss of midbrain dopaminergic neurons. Whereas onset of motor impairments reflects a rather advanced stage of the disorder, hyposmia often marks the beginning of the disease. Little is known about the role of the nigro-striatal system in olfaction under physiological conditions and the anatomical basis of hyposmia in PD. Yet, the early occurrence of olfactory dysfunction implies that pathogens such as environmental toxins could incite the disease via the olfactory system. In the present study, we demonstrate a dopaminergic innervation from neurons in the substantia nigra to the olfactory bulb by axonal tracing studies. Injection of two dopaminergic neurotoxins-1-methyl-4-phenylpyridinium and 6-hydroxydopamine-into the olfactory bulb induced a decrease in the number of dopaminergic neurons in the substantia nigra. In turn, ablation of the nigral projection led to impaired olfactory perception. Hyposmia following dopaminergic deafferentation was reversed by treatment with the D1/D2/D3 dopamine receptor agonist rotigotine. Hence, we demonstrate for the first time the existence of a direct dopaminergic projection into the olfactory bulb and identify its origin in the substantia nigra in rats. These observations may provide a neuroanatomical basis for invasion of environmental toxins into the basal ganglia and for hyposmia as frequent symptom in PD.

show abstract

“…In the presence of regulatory growth factors, NSCs in the SVZ can proliferate through symmetric division and generate progenitor cells of neurons through asymmetric division. These progenitor cells migrate from the SVZ to the olfactory bulb through the rostral migratory stream (RMS) (O'Keeffe et al, 2009;Curtis et al, 2011). The RMS in the adult brain is a vestigial lumen that connects the lateral ventricle to the olfactory ventricle.…”

Section: Neurogenesis In the Adult Mammalian Brainmentioning

confidence: 99%

Neural stem cells: mechanisms and modeling

Yao

Gage

2012

Protein Cell

View full text Add to dashboard Cite

In the adult brain, neural stem cells have been found in two major niches: the hippocampus and the olfactory bulb. Neurons derived from these stem cells contribute to learning, memory, and the autonomous repair of the brain under pathological conditions. Hence, the physiology of adult neural stem cells has become a significant component of research on synaptic plasticity and neuronal disorders. In addition, the recently developed induced pluripotent stem cell technique provides a powerful tool for researchers engaged in the pathological and pharmacological study of neuronal disorders. In this review, we briefly summarize the research progress in neural stem cells in the adult brain and in the neuropathological application of the induced pluripotent stem cell technique.

show abstract

Dopaminergic modulation of neurogenesis in the subventricular zone of the adult brain

Cited by 86 publications

References 34 publications

3.146 Modulation of Adult Neurogenesis in the Olfactory Bulb in an Acute Mouse Model of Parkinson's Disease

3.146 Modulation of Adult Neurogenesis in the Olfactory Bulb in an Acute Mouse Model of Parkinson's Disease

A new dopaminergic nigro-olfactory projection

Neural stem cells: mechanisms and modeling

Contact Info

Product

Resources

About