The potential role of interleukin‐17 in the immunopathology of periodontal disease

Abstract

These results indicate that IL-17 is produced in periodontal lesions, which may be involved in Th1 modulation and enhance inflammatory reactions via gingival fibroblast-derived mediators in periodontal disease. Thus, IL-17, together with other cytokines, has a potential role in the aetiopathogenesis of periodontal disease.

Niveles de interleukina 17 en el fluido gingival crevicular de pacientes con peridontitis crónica progresiva

“…De acuerdo con el estudio de Takahashi et al (14), la IL-17 se produce en la lesion periodontal y puede tener un papel activo en la etiopatogenia de la enfermedad periodontal.…”

“…Takahashi et al (14) demostraron que IL-17 es producida localmente por las célu-IL-17 Inmunoassay, Quantikine, R&D, Inc, Minneapolis, USA. The statistical data was analysed by Stata 7.0 using an unpaired Student t-test.…”

Glycemic control and the production of cytokines in diabetic patients with chronic periodontal disease

“…IFN-γ induces macrophage activation and the production of inflammatory mediators and it is also able to suppress the activity of Th2 cells 22 . Therefore, high levels of this cytokine have been related to periodontal disease progression [22][23] . Controversially, Santos et al 24 and Ribeiro et al 20 also found a higher expression of cytokines in patients with wellcontrolled diabetes and periodontal disease.…”

“…IL-17 is a pro-inflammatory cytokine produced by Th17 cells, which stimulates the production of proinflammatory mediators 23 . Chronic periodontitis sites have shown increased levels of IL-17 in comparison with healthy periodontal tissues [18][19][20][21][22][23] and periodontal pathogens can stimulate the production of IL-17 from T-cells 19 .…”

“…Chronic periodontitis sites have shown increased levels of IL-17 in comparison with healthy periodontal tissues [18][19][20][21][22][23] and periodontal pathogens can stimulate the production of IL-17 from T-cells 19 . In this study, the concentration of the cytokine IL-17 was higher in patients with poorly controlled diabetes, confirming the Table 1.…”