Periodontitis and Systemic Diseases

Vaithilingam, Rathna Devi; Baharuddin, Nor Adinar

doi:10.1002/9781119893035.ch9

Cited by 1 publication

(2 citation statements)

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“…Periodontal diseases (PDs) have been identified as a potential link to numerous pathologies, including rheumatoid arthritis and multiple sclerosis (MS) among these several comorbidities [ 10 , 11 , 12 ]. PDs are long-lasting inflammatory illnesses that impact the components that support the teeth, such as the gums, the periodontal ligament, and the alveolar bone [ 13 , 14 ]. Microbial biofilms are the main cause of these issues, as they induce an inflammatory reaction and can result in tissue damage if not managed [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

“…It primarily stems from inflammation, leading to periodontitis and often resulting in tooth loss. This condition is linked with a systemic inflammatory response, marked by elevated proinflammatory cytokines such as tumor necrosis factor alpha (TNF-α) and interleukin-1β (IL-1β), a decrease in anti-inflammatory molecules like IL-10, and increased serum C-reactive protein levels [ 13 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

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A Systematic Literature Review on Inflammatory Markers in the Saliva of Patients with Multiple Sclerosis: A Cause or a Consequence of Periodontal Diseases

Arcas,

Tig,

Moga

et al. 2024

Medicina

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Background and Objectives: Multiple sclerosis (MS) is a chronic neurodegenerative disease often linked with systemic conditions such as periodontal diseases (PDs). This systematic review aims to explore the association between inflammatory markers in saliva and PDs in MS patients, assessing the use of saliva as a non-invasive tool to monitor disease progression. Materials and Methods: 82 publications were examined after a thorough search of scholarly databases to determine whether inflammatory markers were present in MS patients and whether they were associated with periodontal disease (PD). Quality and bias were assessed using the Newcastle–Ottawa Scale, resulting in eight articles that were thoroughly analyzed. Results: The results point to a strong correlation between MS and periodontal disorders, which may point to the same pathophysiological mechanism. It does, however, underscore the necessity of additional study to determine a definitive causal association. Conclusions: The findings indicate a strong association between MS and PDs, likely mediated by systemic inflammatory responses detectable in saliva. The review highlights the importance of oral health in managing MS and supports the utility of saliva as a practical, non-invasive medium for monitoring systemic inflammation. Further research is necessary to confirm the causal relationships and to consider integrating salivary diagnostics into routine clinical management for MS patients.

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