The potential protective role of coenzyme q10 on the cyclophosphamide-induced lung toxicity in adult male albino rats: a histological and ultrastructural study

Abstract

<p class="abstract"><strong>Background:</strong> Cyclophosphamide is anticancer and immunosuppressant agent used to treat malignant and autoimmune diseases. Its long-term use causes side effects, as infertility and pulmonary toxicity. Coenzyme Q10; the only synthesized antioxidant in human body, acts as powerful antioxidant, scavenging free radicals, and inhibiting lipid peroxidation. Aim of present study was to examine effect of coenzyme Q10 on blood biochemical profiles, histopathological changes in lungs of adult rats exposed to cyclophosphamide-induced toxicity.</p><p class="abstract"><strong>Methods:</strong> 36 adult male albino rats divided into four groups; control and three experimental each having 9 rats. First experimental group received coenzyme Q10, second received cyclophosphamide while third group received coenzyme Q10 along with cyclophosphamide. Experiment lasted for 7 days. On 8th day, animals were sacrificed by decapitation. Lung tissue samples were collected for histopathological examination. SOD (superoxide dismutase) and MDA (malondialdehyde) levels were determined and used for statistical analysis. </p><p class="abstract"><strong>Results:</strong> In coenzyme Q10 treated group, H&E stained sections revealed normal respiratory alveoli. Ultrathin sections revealed normal alveolar septa, pneumocyte and blood capillaries contain erythrocytes. In cyclophosphamide treated group, H&E stained sections revealed peribronchial and interstitial fibrosis. Ultrathin sections revealed alveoli having apparent free lumen with extravasated erythrocytes. Alveolar septa revealed collagen fibrils deposits, and proliferated fibroblasts. In combined coenzyme Q10 and cyclophosphamide treated group, H&E stained sections revealed marked decrease of inter-alveolar tissue thickening. Ultrathin sections revealed destructed alveolar septa with dissociated remnants of collagen fibrils. Blood capillaries appeared wide, containing monocytes and erythrocytes.</p><p class="abstract"><strong>Conclusions:</strong> Administration of coenzyme Q10 with cyclophosphamide is advised to alleviate cyclophosphamide-induced lung toxicity.</p>

Can Coenzyme Q10 alleviate the toxic effect of fenofibrate on skeletal muscle?

“…It also diminished the in ammatory cellular in ltrate. This was supported by other studies which mentioned that the anti brotic effect of CoQ10 could be due to altered pro brotic gene expression and ROS scavenging (Olama et al, 2018). Ekeuku et al (2020) and Mohamed and Said (2021) mentioned that CoQ10 possesses anti-in ammatory and antioxidant properties.…”

The Possible Protective Effect of Melatonin and Coenzyme Q10 on Lung Injury Induced by Bleomycin in Adult Male Albino Rats

“…So, it inhibited lipid peroxidation. Similarly, Olama et al (9) revealed that coenzyme Q10 had a protective role on lung tissue against cyclophosphamide injurious effect in rats. However, Lim et al found that Co Q 10 didn't improve the peak airway pressure and the arterial oxygen in severing lung ischemiareperfusion that could happen in lung transplantation (29) .…”

“…Also, melatonin regulated the connective tissue growth factor, fibronectin and transforming growth factor β (7) .Coenzyme Q10is documented as a dominant systemic antioxidant that prevented the oxidative injury occurs in the essential molecules like DNA, lipids, and proteins (8) . Co Q10 is synthesized in the mitochondria of vital organs as heart, liver and lungs (9) . This study aimed to evaluate the effects of melatonin, Coenzyme Q10 and combination of both of them on pulmonary injury induced by bleomycin.…”

Protective Potential of Saussurea costus (Falc.) Lipsch. Roots against Cyclophosphamide-Induced Pulmonary Injury in Rats and Its In Vitro Antiviral Effect

“… Group II (CP-treated) was given 0.5 % CMC for 10 days and a single IP CP injection (200 mg/kg) on the seventh day [ 29 ]. Group III (SCRE-treated) was given 100 mg/kg SCRE in 0.5 % CMC for 10 days and a single IP CP injection (200 mg/kg) on the seventh day [ 43 , 44 ]. …”

“…Group III (SCRE-treated) was given 100 mg/kg SCRE in 0.5 % CMC for 10 days and a single IP CP injection (200 mg/kg) on the seventh day [ 43 , 44 ].…”