The potential protective effect of two actinomycete extracts against carbon tetrachloride-induced hepatotoxicity in rats

Hozzein, Wael N.; Al-Khalaf, Areej A.; Mohany, Mohamed; Al-Rejaie, Salim S.; Ali, Dalia M. I.; Amin, Asmaa A.

doi:10.1007/s11356-018-3904-z

Cited by 5 publications

(2 citation statements)

References 37 publications

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“…A previous study measuring ALT, AST, and LDH in serum showed that actinomycete extracts protected against CCl 4 -induced liver damage, and that this extract prevented necrosis of hepatocytes and infiltration of inflammatory cells [22]. In the current study, a significant increase in the serum activities of ALT, AST, and LDH in CCl 4 -treated rats indicated the presence of severe liver damage.…”

Section: Discussionsupporting

confidence: 63%

CCl₄-Induced Liver Injury Was Ameliorated by Qi-Ge Decoction through the Antioxidant Pathway

Peng

Zhou

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Qi-Ge decoction (QGD), which is derived from the Huangqi Gegen decoction, contains three traditional Chinese herbs: Astragalus membranaceus (Huangqi), Pueraria lobata (Gegen), and Citri Reticulatae Blanco Pericarpium (Chenpi). Gastric mucosal damage caused by ethanol was prevented and alleviated by QGD. However, the role of QGD in protecting the liver from toxins has not been reported. High-performance liquid chromatography with diode-array detection was used to qualitatively analyze QGD. Positive control (silymarin 100 mg/kg/day), QGD (20, 10, or 5 g/kg/day), and Nrf2 inhibitor brusatol (0.4 mg/kg/2 d) were administered to rats for 7 days, and then, liver injury was induced by injecting 2 mL/kg 25% CCl4. After 24 h, blood and liver were collected for analysis and evaluation. QGD was found to contain 12 main components including calycosin, puerarin, and hesperidin. QGD treatment significantly reduced liver damage and decreased serum alanine aminotransferase, aspartate aminotransferase, and lactate dehydrogenase activities. QGD increased superoxide dismutase and catalase activities, and glutathione levels, but decreased malondialdehyde levels in livers from CCl4-treated rats. Compared to rats treated with CCl4 alone, after QGD administration, mRNA and protein levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 were increased, while those of Kelch-like ECH-related protein 1 (Keap1) and cytochrome P450 (CYP)2E1 were decreased. However, these improvements in QGD were reversed by brusatol. In conclusion, QGD can achieve its hepatoprotective effect through an antioxidant mechanism by activating the Nrf2 pathway.

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Section: Discussionsupporting

confidence: 63%

CCl₄-Induced Liver Injury Was Ameliorated by Qi-Ge Decoction through the Antioxidant Pathway

Peng

Zhou

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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“…A similar protective effect was found for two actinomycete extracts against CCl4-induced liver damage in rats. This protective effect occurred through the reduction of oxidative stress and improvement of antioxidant defense markers [ 25 ]. Activity of enzymes involved in the detoxification of ROS was observed in methanolic extracts from Streptomyces sp.…”

Section: Discussionmentioning

confidence: 99%

Influence of Cultivation Conditions on the Sioxanthin Content and Antioxidative Protection Effect of a Crude Extract from the Vegetative Mycelium of Salinispora tropica

et al. 2021

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Due to their bioavailability, glycosylated carotenoids may have interesting biological effects. Sioxanthin, as a representative of this type of carotenoid, has been identified in marine actinomycetes of the genus Salinispora. This study evaluates, for the first time, the effect of cultivation temperature (T) and light intensity (LI) on the total cellular carotenoid content (TC), antioxidant activity (AA) and sioxanthin content (SX) of a crude extract (CE) from Salinispora tropica biomass in its vegetative state. Treatment-related differences in TC and SX values were statistically significantly and positively affected by T and LI, while AA was most significantly affected by T. In the S. tropica CE, TC correlated well (R2 = 0.823) with SX and somewhat less with AA (R2 = 0.777). A correlation between AA and SX was found to be less significant (R2 = 0.731). The most significant protective effect against oxidative stress was identified in the CE extracted from S. tropica biomass grown at the highest T and LI (CE-C), as was demonstrated using LNCaP and KYSE-30 human cell lines. The CE showed no cytotoxicity against LNCaP and KYSE-30 cell lines.

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Efficacy of two actinomycete extracts in the amelioration of carbon tetrachloride–induced oxidative stress and nephrotoxicity in experimental rats

Hozzein

Al-Khalaf

Mohany

et al. 2019

Environ Sci Pollut Res

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The potential protective effect of two actinomycete extracts against carbon tetrachloride-induced hepatotoxicity in rats

Cited by 5 publications

References 37 publications

CCl₄-Induced Liver Injury Was Ameliorated by Qi-Ge Decoction through the Antioxidant Pathway

CCl₄-Induced Liver Injury Was Ameliorated by Qi-Ge Decoction through the Antioxidant Pathway

Influence of Cultivation Conditions on the Sioxanthin Content and Antioxidative Protection Effect of a Crude Extract from the Vegetative Mycelium of Salinispora tropica

Efficacy of two actinomycete extracts in the amelioration of carbon tetrachloride–induced oxidative stress and nephrotoxicity in experimental rats

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The potential protective effect of two actinomycete extracts against carbon tetrachloride-induced hepatotoxicity in rats

Cited by 5 publications

References 37 publications

CCl4-Induced Liver Injury Was Ameliorated by Qi-Ge Decoction through the Antioxidant Pathway

CCl4-Induced Liver Injury Was Ameliorated by Qi-Ge Decoction through the Antioxidant Pathway

Influence of Cultivation Conditions on the Sioxanthin Content and Antioxidative Protection Effect of a Crude Extract from the Vegetative Mycelium of Salinispora tropica

Efficacy of two actinomycete extracts in the amelioration of carbon tetrachloride–induced oxidative stress and nephrotoxicity in experimental rats

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Product

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CCl₄-Induced Liver Injury Was Ameliorated by Qi-Ge Decoction through the Antioxidant Pathway

CCl₄-Induced Liver Injury Was Ameliorated by Qi-Ge Decoction through the Antioxidant Pathway