Efficacy of two actinomycete extracts in the amelioration of carbon tetrachloride–induced oxidative stress and nephrotoxicity in experimental rats

Efficacy of Olive Oil In Amelioration of Nephrotoxicity In Experimental Male Rats

“…and CCL 3 OO . cause the destruction of kidney cells and organelle membranes by promoting extracellular matrix (ECM) synthesis and deposition, which is included various protein complexes, such as elastin, collagen, glycoproteins, and proteoglycan [30]. The administration of CCL 4 led to an increase in urea, creatinine, and uric acid concentrations, which indicates acute renal failure with proximal tubule harm [31], and these results were in accordance with other studies [32].…”

Chemical characterization and evaluation of the nephroprotective potential of Parrotiopsis jacquemontiana (Decne) Rehder and Periploca hydaspidis Falc crude extract in CCl4-induced Male Sprague-Dawley Rats

“…It not only prompts the lipid peroxidation (LPO) and altered redox status of tissues but also cause serious DNA damage and histopathological appearance ( Ali et al, 2021a , Ali et al, 2021b ). A single injection of CCl 4 instigates DNA oxidative damage via generating DNA-strand breaks in blood lymphocytes detected by comet assay ( Chu et al, 2016 ) whereas interstitial mononuclear cell-infiltration, renal-tubule dilation, glomerular atrophy, and fibrosis in tissue samples ( Hozzein et al, 2019 ). Wide-spread DNA-strand breaks caused via CCl 4 toxicity may cause cell transformation and ultimate death of that cell ( Sajid et al, 2016 ).…”