The Potential Protective Action of Vitamin D in Hepatic Insulin Resistance and Pancreatic Islet Dysfunction in Type 2 Diabetes Mellitus

Leung, Po Sing

doi:10.3390/nu8030147

Cited by 116 publications

(93 citation statements)

References 90 publications

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“…IR leads to severely dysregulated glucose and lipid homeostasis, resulting in a worsening of insulin insensitivity in these organs, eventually leading to lipid accumulation [37]. In our study, the lipid accumulation in the liver and the bigger adipocyte size were observed in KK-Ay model mice.…”

Section: Discussionsupporting

confidence: 54%

Anti-diabetic activity of stigmasterol from soybean oil by targeting the GLUT4 glucose transporter

Wang

Yang

et al. 2017

Food & Nutrition Research

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The present study investigated the anti-diabetic activity and potential mechanism of stigmasterol (SMR), which is a kind of phytosterols derived from the edible soybean oil in vitro and in vivo. SMR displayed a mild GLUT4 translocation activity by 1.44-fold in L6 cells. L6 cells were treated with different concentration of SMR, showing significant effects on the enhancing glucose uptake. SMR administrated orally to the KK-Ay mice significantly alleviated their insulin resistance and oral glucose tolerance with reducing fasting blood-glucose levels and blood lipid indexes such as triglyceride and cholesterol. Moreover, the GLUT4 expression in L6 cells, skeletal muscle and white adipose tissue had been also enhanced. In this paper we conclude that, stigmasterol seems to have potential beneficial effects on the treatment of type 2 diabetes mellitus with the probable mechanism of targeting GLUT4 glucose transporter included increasing GLUT4 translocation and expression.

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Section: Discussionsupporting

confidence: 54%

Anti-diabetic activity of stigmasterol from soybean oil by targeting the GLUT4 glucose transporter

Wang

Yang

et al. 2017

Food & Nutrition Research

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“…Vitamin D supplementation for diabetic patients is of particular interest, with regard to its role in glucose hemostasis and thus its use as a potential cost-effective adjunct therapy in T2DM management [14,15] . However, data on the impact of maintaining an adequate vitamin D status or supplementing with vitamin D on clinical outcomes in diabetic patients are inconsistent, probably reflecting the differences across studies in baseline vitamin D levels and replacement therapy dosage [14][15][16] .…”

Section: Introductionmentioning

confidence: 99%

The Association of Vitamin D Status and Vitamin D Replacement Therapy with Glycemic Control, Serum Uric Acid Levels, and Microalbuminuria in Patients with Type 2 Diabetes and Chronic Kidney Disease

Sipahi¹,

Açıkgöz

Genç

et al. 2016

Med Princ Pract

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Objective: To evaluate the relationship of vitamin D status and vitamin D replacement therapy with glycemic control, serum uric acid (SUA) levels, and microalbuminuria (MAU) in patients with type 2 diabetes (T2DM) and chronic kidney disease (CKD). Subjectsand Methods: A total of 1,463 patients with T2DM and CKD (aged 14-88 years), 927 females and 536 males, were included in this study. The serum data of 25-hydroxyvitamin D, i.e., 25(OH)D, level, SUA, hemoglobin (Hb)A1_c, creatinine, estimated glomerular filtration rate, and urine albumin-to-creatinine ratio (UACR) were obtained from the medical records. The Mann-Whitney U test, the χ² test, the Mantel-Haenszel test, and linear regression models were used for data analysis. Results: Vitamin D deficiency and insufficiency were evident in 770 (52.0%) and 357 (24.0%) patients, respectively. Median HbA1_c levels (7.3 [IQR 3.9] vs. 6.5 [IQR 2.3]%; p < 0.01) were significantly higher in patients deficient in vitamin D than in those with a normal vitamin D status. A significantly low level of vitamin D was noted with a high UACR (β −0.01; 95% CI −0.01 to −0.001; p = 0.017) and HbA1_c (β −1.1; 95% CI −1.6 to −0.6; p < 0.001), but with low levels of SUA (β 1.3; 95% CI 0.5-2.2; p = 0.002). Vitamin D replacement was associated with a significantly low level of HbA1_c (7.4 [2.7] vs. 6.7 [1.9]%; p < 0.001]. Conclusion: In this study, there was a high prevalence of hypovitaminosis D among T2DM patients with CKD, with a higher UACR, higher HbA1_c, and lower SUA being noted as playing a role in predicting a decrease in vitamin D levels and potential benefits of vitamin D replacement therapy on glycemic control in T2DM management.

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“…В своем исследо-вании Leung и соавт. [37] на основании предварительно полученных данных показали, что высокие дозы кальци-триола улучшают аномальные печеночные показатели липидного и углеводного обмена как in vitro (1-10 нМ в HepG2 клетках), так и in vivo (0,5-2,5 мк/кг в течение 2 дней у db/db мышей) в моделях инсулинорезистентно-сти без каких-либо токсических эффектов кальцитриола. Кроме того, они провели эксперименты, показывающие, что увеличение цитозольного кальцитриола в HepG2 клетках активирует Са 2+ /CaMKKβ/АМФК путь, в резуль-тате чего происходит регуляция обмена липидов и глю-козы.…”

Section: витамин D и печеночный метаболизмunclassified

“…Адаптировано Leung и соавт. [37]. Влияние витамина D на липо-генез, синтез и накопление триглицеридов и глюконеогенез в печени.…”

Section: витамин D и функция β-клеток поджелудочной железыunclassified

Non-classical effects of vitamin D

Ваниковна¹

2018

Obes. metabol.

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1ФГБУ "Национальный медицинский исследовательский центр эндокринологии" Минздрава России, г. Москва 2 ГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова», г. Москва Существуют данные об участии витамина D в модуляции воспалительной реакции и развитии сахарного диабета. Поскольку активация провоспалительных биомаркеров и цитокинов препятствует нормальному обмену веществ и нарушает синтез инсулина и чувствительность тканей к нему, предполагается, что витамин D может влиять на гомеос-таз липидов и глюкозы путем модуляции воспалительной реакции и ренин-ангиотензиновой системы. В статье пред-ставлен обзор литературы, обобщающий данные о механизмах влияния дефицита витамина D на метаболические нарушения.КЛЮЧЕВЫЕ СЛОВА: витамин D, сахарный диабет, инсулинорезистентность, метаболический синдром, ожирение, артериальное давление, ренин-ангиотензиновая система. NON-CLASSICAL EFFECTS OF VITAMIN D© Egshatyan L.V. Since the activation of inflammatory biomarkers, cytokines and pathways interferes with normal metabolism and disrupts proper insulin signaling and insulin resistance, it is hypothesized that vitamin D could influence lipid and glucose homeostasis by modulating inflammatory response and renin-angiotensin system. In this review discussed the mechanisms of the influence of vitamin D on metabolic disease.

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The Potential Protective Action of Vitamin D in Hepatic Insulin Resistance and Pancreatic Islet Dysfunction in Type 2 Diabetes Mellitus

Cited by 116 publications

References 90 publications

Anti-diabetic activity of stigmasterol from soybean oil by targeting the GLUT4 glucose transporter

Anti-diabetic activity of stigmasterol from soybean oil by targeting the GLUT4 glucose transporter

The Association of Vitamin D Status and Vitamin D Replacement Therapy with Glycemic Control, Serum Uric Acid Levels, and Microalbuminuria in Patients with Type 2 Diabetes and Chronic Kidney Disease

Non-classical effects of vitamin D

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