Anti-diabetic activity of stigmasterol from soybean oil by targeting the GLUT4 glucose transporter

Wang, Jialin; Mi, Huang; Yang, Jie; Ma, Xiaochun; Zheng, Sijian; Deng, Shihao; Huang, Yun; Yang, Xinzhou; Zhao, Ping

doi:10.1080/16546628.2017.1364117

Cited by 99 publications

(58 citation statements)

References 52 publications

(53 reference statements)

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“…Other research groups reported reduced abdominal, visceral, and subcutaneous fat after phytosterols consumption in healthy subjects, without imposing adverse events such as reduced serum fat‐soluble vitamins levels (Saito et al, ; Takeshita et al, ). Improving insulin sensitivity and glucose metabolism after PS supplementation (Wang et al, ; Xiong et al, ) also has been reported. Expression and translocation of glucose transporter 4 in the skeletal muscle, white adipose tissue, and liver reported to be increased after PS supplementation (Subash‐Babu, Ignacimuthu, & ALSHATWI, ; Xiong et al, ).…”

Section: Discussionmentioning

confidence: 86%

Possible anti‐obesity effects of phytosterols and phytostanols supplementation in humans: A systematic review and dose–response meta‐analysis of randomized controlled trials

Ghaedi

Varkaneh

Rahmani

et al. 2019

Phytotherapy Research

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Present meta‐analysis investigates the effects of phytosterols and phytostanol (PS) supplementation on anthropometric indices, using data from randomized controlled trials. We performed a systematic search in the databases: PubMed, Scopus, Cochran, and Web of Science. Weighted mean difference (WMD) with 95% confidence intervals (CIs) were presented. Overall, 79 randomized controlled trials investigated the effects of PS on anthropometric indices. Meta‐analysis results did not reveal any significant effect of PS supplementation on weight (66 trials‐WMD: −0.083 kg; CI [−0.233, 0.066]; I2 = 42.5%), percentage fat mass (6 trials‐WMD: −0.090%; CI [−0.789, 0.610]; I2 = 0.0%), and waist circumference (WC; 5 trials‐WMD: −0.039 cm; CI [−0.452, 0.374]; I2 = 0.0%). However, body mass index (BMI) significantly decreased after PS supplementation (39 trials‐WMD: −0.063 kg/m2, p = 0.024, I2 = 25.1%). Subgroup analyses showed that PS supplementation in subjects with baseline BMI ≥25 and hyperlipidemic significantly decreased body weight and BMI. The overall results showed that although PS supplementation did not affect anthropometric indices (except BMI), baseline status regarding BMI and hyperlipidemia and also dose and duration could be contributing factors for favorable effects.

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Section: Discussionmentioning

confidence: 86%

Possible anti‐obesity effects of phytosterols and phytostanols supplementation in humans: A systematic review and dose–response meta‐analysis of randomized controlled trials

Ghaedi

Varkaneh

Rahmani

et al. 2019

Phytotherapy Research

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“…Stigmasterol was anti-diabetic, WARD et al [42] found that stigmasterol could improve the increase of free cholesterol caused by glucolipid toxicity in insulinoma cells (INS-1), which led to defects in insulin secretion, increased total insulin, and promoted stimulus protein recombination and also had been shown that played a bene cial role in the treatment of T2DM. Wang et al [43] found that in vitro experiments, treating of L6 cells with different concentrations of stigmasterol had a signi cant effect on promoting glucose uptake. In the in vivo test, after oral administration of stigmasterol, fasting blood glucose levels and blood lipid indexes (such as triacylglycerol and cholesterol) in KK-AY mice were signi cantly reduced, which signi cantly reduced insulin resistance and oral glucose tolerance in KK-AY mice.…”

Section: Discussionmentioning

confidence: 99%

The Mechanism of Jinqi Jiangtang Tablet in Treatment of Type 2 Diabetes Mellitus Based on Network Pharmacology

Yang

Song

Bing

et al. 2020

Preprint

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Background: Type 2 Diabetes Mellitus(T2DM) is an endocrine disease that caused mainly by insulin resistance (IR) and β cell dysfunction. The incidence of T2DM is quite high in the worldwide. To explore the molecular mechanism of Jinqi Jiangtang Tablet(JJT) in treating of T2DM based on Network Pharmacology. Methods: The active compounds, targets of three Traditional Chinese medicines in JJT were obtained by the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform（TCMSP） database and Uniprot database; The targets of T2DM were screened through the Drugbank database; The compound-target network was constructed via the Cytoscape 3.7.2 software and used the built-in Network analyzer to analyze and select the key active compounds; The overlapping targets of drug and disease targets were gained by the VENNY online tool and the targets were built by STRING website to select the key genes; Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway were performed on the potential targets using DAVID6.8 online tool to study the mechanism of overlapping targets. Via Systems Dock platform to validate the interaction between compound and targets Results: Twenty-five active compounds of JJT were screened, 101 drug targets, 142 disease targets and twenty-one overlapping targets. GO enrichment analysis showed that the biological processes (BP)mainly included the blood circulation ,etc. Cell composition(CC) mainly affected the integral component of plasma membrane, etc. Molecular functions(MF) mainly involved alpha-adrenergic receptor activity, etc. KEGG pathway analysis showed that there were twelve pathways related to T2DM, among which PPAR signaling pathway was related to T2DM mostly. RXRA is one of key targets of JJT and berberine performed well. Conclusions: This study revealed the mechanism of JJT in treatment of T2DM preliminarily and supplied a further foundation for studying its mechanism.

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“…In skeletal muscle, insulin stimulation induces translocation of GLUT4 from intracellular vesicles within the cytoplasm to the plasma membrane and thereby increases glucose uptake [18,19]. When insulin levels decrease in the blood and insulin receptors are no longer occupied, the glucose transporters are recycled back into the cytoplasm.…”

Section: Glucose Metabolism In Skeletal Musclementioning

confidence: 99%

The Role of Glucose and Fatty Acid Metabolism in the Development of Insulin Resistance in Skeletal Muscle

Mazibuko-Mbeje¹,

Dludla²,

Nkambule³

et al. 2018

Muscle Cell and Tissue - Current Status of Research Field

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The rapid rise in the prevalence of obesity and diabetes has significantly contributed to the increasing global burden of noncommunicable diseases. Insulin resistance is a major underpinning etiology of both obesity and type 2 diabetes. Insulin resistance is characterized by a reduced response of skeletal, liver, and fat tissues to the actions of insulin hormone. Although detailed mechanisms implicated in the development of insulin resistance remain plausible, skeletal muscles have been identified to play an integral role in the improvement of insulin sensitivity in the diseased state. The effective modulation of glucose and fatty acid metabolism in the skeletal muscle through exercise or by certain therapeutics has been associated with reversal of insulin resistance and amelioration of diabetes associated complications such as inflammation and oxidative stress. This chapter will briefly discuss the role of glucose and fatty acid metabolism in the development of insulin resistance in the skeletal muscle.

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Anti-diabetic activity of stigmasterol from soybean oil by targeting the GLUT4 glucose transporter

Cited by 99 publications

References 52 publications

Possible anti‐obesity effects of phytosterols and phytostanols supplementation in humans: A systematic review and dose–response meta‐analysis of randomized controlled trials

Possible anti‐obesity effects of phytosterols and phytostanols supplementation in humans: A systematic review and dose–response meta‐analysis of randomized controlled trials

The Mechanism of Jinqi Jiangtang Tablet in Treatment of Type 2 Diabetes Mellitus Based on Network Pharmacology

The Role of Glucose and Fatty Acid Metabolism in the Development of Insulin Resistance in Skeletal Muscle

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