The potential of self-assembled, pH-responsive nanoparticles of mPEGylated peptide dendron–doxorubicin conjugates for cancer therapy

“…36,37 Double nanocapsules designed to encapsulate proteins in their separated microsphere structures can protect the structural and functional integrities of proteins when they are transported into the cytosol and then redistributed within the cells. [38][39][40] Besides the transport of BSA into the cytosol, the study showed that the nanocapsules delivered NLS-GFP into the nucleus, indicating that the structure of nanocapsules did not interfere with the migration of proteins.…”

Section: Discussionmentioning

confidence: 99%

Biodegradable double nanocapsule as a novel multifunctional carrier for drug delivery and cell imaging

Qian

Zhang

et al. 2015

IJN

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Highly-efficient delivery of macromolecules into cells for both imaging and therapy (theranostics) remains a challenge for the design of a delivery system. Here, we suggested a novel hybrid protein–lipid polymer nanocapsule as an effective and nontoxic drug delivery and imaging carrier. The biodegradable nanocapsules showed the typical double emulsion features, including fluorescently labeled bovine serum albumin shell, oil phase containing poly(lactic-co-glycolic acid) and linoleic acid, and inner aqueous phase. The nanocapsules were spherical in shape, with an average size of about 180 nm. Proteins packed into the inner aqueous phase of the nanocapsules could be delivered into cells with high efficiency, and the fluorescence of the fluorescently labeled bovine serum albumin could be used for tracing the protein migration and cellular location. Further studies suggested that the co-delivery of transcription factor p53 and lipophilic drug paclitaxel with the nanocapsules acted synergistically to induce Hela cell apoptosis, and the fluorescence of apoptotic cells was clearly observed under a fluorescence microscope. Such multifunctional delivery system would have great potential applications in drug delivery and theranostic fields.

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“…The characteristics and quantitative of CMβ-CD are shown in Figure S1 to S5.). For the obtained CMβ-CDs, β-CD-(CH 2 COOH) 4 through β-CD-(CH 2 COOH) 7 are the main CMβ-CD components. Three different GCS-CMβ-CDs (GCS 7.4 -CMβ-CD, GCS 13.0 -CMβ-CD, and GCS 23.3 -CMβ-CD) were obtained by adjusting the concentrations of NaCl during the reaction of CMβ-CD and GCS (Table S1).…”

Section: Preparation Of Blank and Drug-loaded Gcs-cmβ-cd Npsmentioning

confidence: 99%

“…The synthesized CMβ-CDs were composed of β-CD-(CH 2 COOH) 2 , β-CD-(CH 2 COOH) 3 , β-CD-(CH 2 COOH) 4 , β-CD-(CH 2 COOH) 5 , β-CD-(CH 2 COOH) 6 , and β-CD-(CH 2 COOH) 7 indicating that more than one carboxymethyl combined with β-CD. One reacted with GCS, but there were also many free carboxymethyl groups around the CMβ-CD cavity.…”

mentioning

confidence: 99%

pH-responsive glycol chitosan-cross-linked carboxymethyl-β-cyclodextrin nanoparticles for controlled release of anticancer drugs

Wang¹,

Qin²,

Tan³

et al. 2015

IJN

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Carboxymethyl-β-cyclodextrin (CMβ-CD)-modified glycol chitosan (GCS) nanoparticles (GCS-CMβ-CD NPs) were synthesized, and their pH-sensitive drug-release properties were investigated. GCS-CMβ-CD NPs could encapsulate doxorubicin hydrochloride (DOX), and the encapsulation efficiency and loading capacity increased with the amount of CMβ-CD. Drug-release studies indicate that DOX released was greater in acidic medium (pH 5.0) than in weakly basic medium (pH 7.4). The mechanism underlying the pH-sensitive properties of the carrier was analyzed. Finally, the MCF-7 (human breast cancer) and SW480 cell lines (human colon cancer) were used to evaluate the cytotoxicity of the NPs. The drug-loaded carriers show good inhibition of the growth of cancer cells compared with free DOX, and the carriers have good biocompatibility. In addition, the drug-loaded NPs have sustained drug-release properties. All these properties of the newly synthesized GCS-CMβ-CD NPs suggest a promising potential as an effective anticancer drug-delivery system for controlled drug release.

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The potential of self-assembled, pH-responsive nanoparticles of mPEGylated peptide dendron–doxorubicin conjugates for cancer therapy

Cited by 255 publications

References 58 publications

Controlling the number of dendrimers in dendrimicelle nanoconjugates from 1 to more than 100

Controlling the number of dendrimers in dendrimicelle nanoconjugates from 1 to more than 100

Biodegradable double nanocapsule as a novel multifunctional carrier for drug delivery and cell imaging

pH-responsive glycol chitosan-cross-linked carboxymethyl-β-cyclodextrin nanoparticles for controlled release of anticancer drugs

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The potential of self-assembled, pH-responsive nanoparticles of mPEGylated peptide dendron–doxorubicin conjugates for cancer therapy

Cited by 255 publications

References 58 publications

Controlling the number of dendrimers in dendrimicelle nanoconjugates from 1 to more than 100

Controlling the number of dendrimers in dendrimicelle nanoconjugates from 1 to more than 100

Biodegradable double nanocapsule as a novel multifunctional carrier for drug delivery and cell&nbsp;imaging

pH-responsive glycol chitosan-cross-linked carboxymethyl-&beta;-cyclodextrin nanoparticles for controlled release of anticancer drugs

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Product

Resources

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Biodegradable double nanocapsule as a novel multifunctional carrier for drug delivery and cell imaging

pH-responsive glycol chitosan-cross-linked carboxymethyl-β-cyclodextrin nanoparticles for controlled release of anticancer drugs